RESUMO

Resumen La dermatosis pustulosa subcórnea (DPS), oenfermedad de Sneddon-Wilkinson, es una dermatosis poco frecuente, benigna, de curso crónico y recidivante. En esta oportunidad presentaremos el caso de una paciente femenina de 58 años condiagnóstico de dermatosis pustulosa subcórnea, que fue tratada con dapsona 100mg por día, con resolución de lesiones. Realizamos unarevisión bibliográfica de esta patología describiendo sus características clínicas e histológicas, sus múltiples diagnósticos diferenciales y las posibles terapéuticas.

Abstract Subcorneal pustular dermatosis, or Sneddon-Wilkinson disease, is a rare, benign, chronic and recurrent dermatosis. We reportthe case of a 58-year-old female patient with subcorneal pustular dermatosis, who was treated with dapsone 100mg per day, with goodtherapeutic response. We carried out a bibliographic review of this pathology describing its clinical and histological characteristics, its multiple differential diagnoses and possible therapeutic options.

RESUMO

Introducción: Actualmente, no se conocen los factores de riesgo de morbimortalidad postoperatoria en los pacientes que son intervenidos por una hernia de pared abdominal complicada operada de urgencia mediante una hernioplastía con malla. El objetivo principal es determinar los factores de riesgo de presentar una complicación durante el postoperatorio, en pacientes operados de urgencia con diagnóstico de hernia de pared abdominal complicada mediante una hernioplastía con malla en el Hospital Base Osorno (HBO) entre los años 2002 y 2008. Material y métodos: Cohorte retrospectiva. Se seleccionaron los pacientes mayores de 14 años operados por patología herniaria del registro de cirugías del Servicio de Urgencia del Hospital Base Osorno (HBO) entre los años 2002 y 2008. Se excluyeron a aquellos operados sin malla. Se estimó el riesgo, mediante Odds ratio (OR) y su intervalo de confianza 95 por ciento. Software utilizado: Stata 10.0. Resultados: La cohorte incluyó 52 pacientes, mediana de edad 64 años (26-85). El 50 por ciento (26 pacientes) fueron de sexo masculino. La ubicación herniaria más frecuente fue la inguinal con 23 casos (44,23 por ciento). 49 (94,23 por ciento) hernias se catalogaron como atascadas y 3 (5,77 por ciento) como estranguladas. Morbilidad operatoria 17,31 por ciento (9 pacientes). Mediana de seguimiento, 32 (5-90) meses. Sólo la instalación de drenaje resultó ser significativa (p<0,05), esta variable resultó tener un OR de 4,7 (IC 95 por ciento:1,09-20,79). Conclusión: En este estudio la instalación de un drenaje al reparar una hernia de pared abdominal complicada con malla, actuaría como factor de riesgo de presentar una complicación durante el postoperatorio.

Introduction: Currently, there are no known risk factors for postoperative complications and mortality in patients who are undergoing surgery for a complicated abdominal wall hernia operated emergency through a hernioplasty with mesh. The main objective is to determine the risk factors for presenting a complication during the postoperative period in patients undergoing emergency with a diagnosis of complicated abdominal wall hernia by a hernioplasty with mesh in the Base Hospital Osorno (HBO) between the years 2002 and 2008. Material and methods: retrospective cohort study. We selected patients older than 14 years operated by hernial pathology of the registration of surgeries of the Emergency Service at the Hospital Base Osorno (HBO) between the years 2002 and 2008. We excluded those operated without mesh. It was felt the risk, using odds ratio (OR) and its confidence interval of 95 percent Software used: Stata 10.0. Results: The cohort included 52 patients, median age 64 years (26-85). The 50 percent (26 patients) were male. The most frequent location hernia was the groin with 23 cases (44.23 percent). 49 (94.23 percent) hernias were catalogd as stuck and 3 (5.77 percent) as being strangled. Operative morbidity 17.31 percent (9 patients). Median follow-up, 32 (5-90 percent) months. Only the installation of drainage turned out to be significant (p<0.05 ), this variable was found to have an OR of 4.7 (IC 95 percent:1,09-20,79). Conclusion: In this study, the installation of a drain after to repair an complicated abdominal wall hernia with mesh would act as a risk factor for presenting a complication during the postoperative period.

Assuntos

RESUMO

Se evaluó un nuevo programa de vacunación contra la Enfermedad Infecciosa de la Bursa que contenía la vacuna complejo virus-anticuerpo en comparación con un programa tradicional bajo condiciones de campo. En cada grupo se utilizó 21,800 pollos de engorde de ambos sexos de la línea Cobb Vantress 500. El grupo experimental recibió un complejo virus-anticuerpo en la planta de incubación a los 18 días de desarrollo embrionario, y el grupo control recibió dos vacunas a virus vivo, Bursine®2 y Bursa Blen, administradas por agua de bebida a los 8 y 19 días de edad, respectivamente. Se determinó en forma semanal y hasta los 47 días de edad, en ambos grupos, el peso corporal, índice de conversión alimenticia (ICA), índice de eficiencia productiva europeo (IEPE), mortalidad, índice bursal, lesiones histopatológicas y niveles de anticuerpos contra el VEIB. Las aves del grupo experimental tuvieron un mejor peso corporal a los 47 días de edad (p<0.05), ICA y IEPE. Ambos grupos mostraron atrofia bursal a partir de los 35 días de edad; sin embargo, los resultados microscópicos mostraron lesiones moderadas de atrofia y depleción linfoide en las bursas del grupo experimental a los 35 días de edad. Los títulos de anticuerpos fueron mayores a los 35 y 42 días de edad en el grupo experimental y en el grupo control a los 47 días (p<0.05). Ambos programas produjeron lesiones de grado variable en las bursas con la estimulación de una respuesta inmune activa; sin embargo, las aves que recibieron la vacuna virus-anticuerpo tuvieron un mejor desempeño productivo.

A new vaccination programme against infectious bursal disease using a virus-antibody complex vaccine in comparison with a traditional programme under field conditions was evaluated. In each group, 21,800 broiler chickens of Cobb Vantress 500 line were used. The experimental group was vaccinated with the strain 2512 in combination with specific antibodies at the incubation plant on day 18 of embryonic development, whereas the control group received two vaccines of live virus, the Bursine®2 and Bursa Blen, administered by drinking water at 8 and 19 days of age respectively. Body weight, feed conversion index, European Production Efficiency Index, mortality, bursal index, histopathological lesions, and antibody levels against IBDV were evaluated. Birds of the experimental group showed higher body weight (p<0.05), and better feed conversion index and production efficiency index at 47 days of age than the control group. Both groups showed bursal atrophy from 35 days of age onwards, however, the histopathological results only showed moderate lesions of atrophy and lymphoid depletion in bursas in both groups during those periods. Antibody titers were higher at 35 and 42 days of age in the experimental group and at 47 days in the control group (p<0.05). Both vaccination programmes produced lesions of variable degree in bursas, nevertheless, birds that received the vaccine complex virus antibody had a better productive performance.

Assuntos

RESUMO

La patología herniaria es frecuente de ver en la práctica del cirujano general y sus complicaciones siguen siendo causa de morbimortalidad. Se presenta una serie de casos con seguimiento de 84 pacientes operados de urgencia con hernia complicada en el Hospital Base de Osorno (HBO) entre 2002 y 2004, seguidos hasta mayo de 2009. Para el análisis estadístico se utilizó el programa estadístico Stata 10. La mediana de edad fue de 64 años. Serie compuesta predominante de mujeres (62 casos), en 72 casos (85,71 por ciento) las hernias estaban atascadas y en 12 (14,28 por ciento) estranguladas. La localización más frecuente fue la umbilical con 29 casos (34,52 por ciento), seguido por la inguinal con 20 (23,80 por ciento). Hubo 12 reparaciones con malla (14,28 por ciento), todas ellas realizadas en hernias atascadas. La mediana de días hospitalización postoperatorios fue de 4 (1-37). Hay 3 casos de mortalidad operatoria (1 inguinal, 1 umbilical y 1 incisional). En 11 (13,10 por ciento) pacientes se mantuvo tratamiento antibiótico durante el postoperatorio, de éstas, 5 fueron hernias estranguladas. En 19 pacientes (22,61 por ciento) se presentó alguna complicación: en 4 (33,33 por ciento) de las estranguladas y en 15 de las atascadas (20,83 por ciento), estas complicaciones fueron 11 (13,10 por ciento) infecciones de herida operatoria y 4 (47,61 por ciento) seromas. En ningún caso fue necesario retirar la malla. En 16 (19,04 por ciento) casos recidivó la hernia. Como conclusión, en esta serie seleccionada de pacientes, el índice de recidiva fue alto, con un bajo porcentaje de uso de malla; sin embargo, la necesidad de retirar la malla por una complicación fue baja.

Assuntos

RESUMO

Systems with global symmetry group O(2) experience topological transition in the two-dimensional space. But there is controversy about such a transition for systems with global symmetry group O(3). As an example of the latter case, we study the Lebwohl-Lasher model for the two-dimensional liquid crystal, using three different methods independent of the proper values of possible critical exponents. Namely, we analyze the at-equilibrium order parameter distribution function with (1) the hyperscaling relation; (2) the first-scaling collapse for the probability distribution function; and (3) the Binder's cumulant. We give strong evidence for definite lack of a line of critical points at low temperatures in the Lebwohl-Lasher model, contrary to conclusions of a number of previous numerical studies.

Assuntos

RESUMO

Se presenta un caso clínico de síndrome de Moebius y artrogriposis asociado al uso de misoprostol durante el primer trimestre de gestación.

We present a case of Moebius syndrome and arthrogriposis associated to the use of misoprostol during the first trimester of gestation.

Assuntos

RESUMO

Parathion is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of Parathion, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of Parathion, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma testosterone was assayed by standard radioimmunoanalysis. The same method was used to assay testosterone in the culture medium of interstitial cells obtained from the control and Parathion treated animals at the same time intervals. Sperm count, sperm teratozoospermia and tubular blockage were analyzed for an appraisal of spermatogenesis. Increase in the teratozoospermia and tubular blockage was detected in the PP and PC group at 8 and 40 days post injection. Plasma testosterone levels drop significantly at 8 days and recovered slowly at 40 days only in PP animals as detected in vivo, implying interference of testicular steroidogenesis due to the toxicant. Recuperation of normality occurs at long time intervals. In conclusion, Parathion disturbs the synthesis of testosterone in mice affecting qualitatively the spermatogenesis.

Assuntos

RESUMO

Parathion is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of Parathion, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of Parathion, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma testosterone was assayed by standard radioimmunoanalysis. The same method was used to assay testosterone in the culture medium of interstitial cells obtained from the control and Parathion treated animals at the same time intervals. Sperm count, sperm teratozoospermia and tubular blockage were analyzed for an appraisal of spermatogenesis. Increase in the teratozoospermia and tubular blockage was detected in the PP and PC group at 8 and 40 days post injection. Plasma testosterone levels drop significantly at 8 days and recovered slowly at 40 days only in PP animals as detected in vivo, implying interference of testicular steroidogenesis due to the toxicant. Recuperation of normality occurs at long time intervals. In conclusion, Parathion disturbs the synthesis of testosterone in mice affecting qualitatively the spermatogenesis.(AU)

Assuntos

RESUMO

Parathion is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of Parathion, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of Parathion, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma testosterone was assayed by standard radioimmunoanalysis. The same method was used to assay testosterone in the culture medium of interstitial cells obtained from the control and Parathion treated animals at the same time intervals. Sperm count, sperm teratozoospermia and tubular blockage were analyzed for an appraisal of spermatogenesis. Increase in the teratozoospermia and tubular blockage was detected in the PP and PC group at 8 and 40 days post injection. Plasma testosterone levels drop significantly at 8 days and recovered slowly at 40 days only in PP animals as detected in vivo, implying interference of testicular steroidogenesis due to the toxicant. Recuperation of normality occurs at long time intervals. In conclusion, Parathion disturbs the synthesis of testosterone in mice affecting qualitatively the spermatogenesis

Assuntos

RESUMO

We examined the genetic makeup of 221 HIV-1 strains from Chilean persons living with HIV/AIDS by HMA and DNA sequencing of the env gene: 143 cases were infected by sexual contact with an already-infected partner, 76 were infected by mother-to-child transmission, and 2 were transfusion related. We found env HIV-1 subtype B in 202 cases (91.4%) and subtype F in 19 cases (8.6%). Subtype B strains were found throughout the country whereas subtype F viruses were predominantly found in cases from the metropolitan/central to the northern regions of Chile (p < 0.01). Chilean F subtypes clustered in two different groups: viruses from the central region clustered with F subtypes from Argentina, Uruguay, and Brazil, and viruses from the northern region, which independently segregated from other South American and European F strains. All of the 59 men having sex with men (MSM) were infected with B subtype strains whereas 7 (9.2%) and 12 (15.8%), respectively, of heterosexually infected females and children were infected with F subtype strains (p < 0.01). It appears that F subtype strains have been introduced into Chile by separate heterosexual transmission events from other nearby countries in the Southern Cone whereas B subtype strains have continued to persist predominantly among MSM.

Assuntos

RESUMO

Se presenta una revisión retrospectiva de 7 casos de tumores cardiacos (TC) fetales con diagnóstico prenatal, controlados en el Centro de Referencia Perinatal Oriente (CERPO) entre 2003-2005. Se analizan los tipos de TC diagnosticados en el período fetal, su influencia y evolución durante la gestación y el manejo perinatal. En las 7 gestantes controladas se diagnosticaron: 4 rabdomiomas, 1teratoma, 1 hemangioma y 1 caso sin estudio anátomo patológico. La edad gestacional promedio al diagnóstico fue de 34 semanas, no hubo una repercusión hemodinámica significativa que motivara intervenciones prenatales. El resultado obstétrico fue satisfactorio, con edad gestacional media al parto de 39 semanas de gestación, peso promedio de recién nacido (RN) 3.536 g y sin Apgar menores de 8 en los RN, excepto en el caso Nº 5 que se discutirá. Un RN cuyo TC estaba asociado a hipoplasia de ventrículo derecho e hipoplasia pulmonar, falleció a los 8 días. Se realizó seguimiento postnatal entre 4 meses y 1 año, 2 casos (teratoma y hemangioma) requirieron cirugía. Todos los pacientes se encuentran en buenas condiciones, con adecuado desarrollo pondoestatural y psicomotor y en controles cardiológicos periódicos.

Assuntos

RESUMO

Plum pox virus (PPV) strain D was first detected in Chile in 1992 infecting Prunus trees including peaches, nectarines, apricots, and plums. Since then, quarantine efforts have included periodic surveys in the central zone of the country, the main region for stone fruit production. This work describes the characterization of six PPV isolates from this area of Chile, using biological and molecular approaches. PPV isolates were introduced into Prunus tomentosa and Nicotiana benthamiana hosts by grafting and mechanical inoculation, respectively. Symptoms were evaluated by following the appearance of circular necrotic spots and mosaic in leaves of P. tomentosa and mosaic and some leaf deformation in N. benthamiana. Molecular analysis was carried out using reverse transcription-polymerase chain reaction, allowing the cloning and sequencing of 1.34-kb fragments corresponding to the 3' region of the replicase gene, the complete coat protein (CP) gene, and the 3' nontranslated region of the PPV genome. Evolutionary distance analysis of these nucleotide sequences and their deduced coat protein amino acid sequences grouped the six Chilean isolates among strain D isolates, with closest genetic distances to those of Central Germany and Poland. Representative sources of these isolates suggest that strain D could be the only type of PPV currently present in Chile.

RESUMO

Presentamos la experiencia y evolución del parto instrumentado en nuestro Servicio de Obstetricia y Ginecología, en los últimos once años 1992-2002. La evidencia demostró que respecto de las lesiones maternas y fetales, las Espátulas (ET), o instrumento no articulado de la clasificación general de los fórceps (F), son significativamente menores cuando se las compara con el fórceps articulado y fenestrado de Kjelland o Kielland (FK), por lo que se sugiere su conocimiento y adiestramiento en los Servicios de la especialidad, y cambiar el concepto de la presa del cráneo-fetal o biparieto malar por la toma libre facio malar.

Assuntos

RESUMO

We study a model of concentrated suspensions under shear in two dimensions. Interactions between suspended particles are dominated by direct-contact viscoelastic forces and the particles are neutrally bouyant. The bimodal suspensions consist of a variable proportion between large and small droplets, with a fixed global suspended fraction. Going beyond the assumptions of the classical theory of Farris (R.J. Farris, Trans. Soc. Rheol. 12, 281 (1968)), we discuss a shear viscosity minimum, as a function of the small-to-large-particle ratio, in shear geometries imposed by external body forces and boundaries. Within a linear-response scheme, we find the dependence of the viscosity minimum on the imposed shear and the microscopic drop friction parameters. We also discuss the viscosity minimum under dynamically imposed shear applied by boundaries. We find a reduction of macroscopic viscosity with the increase of the microscopic friction parameters that is understood using a simple two-drop model. Our simulation results are qualitatively consistent with recent experiments in concentrated bimodal emulsions with a highly viscous or rigid suspended component.

RESUMO

Presentamos el caso clínico de gemela unida o siamés toracoonfalópago. Se destaca el diagnóstico prenatal, el manejo clínico y la resolución planificada del parto por operación cesárea, contando con un apoyo neonatológico de cuidado intensivo. Se da a conocer una revisión bibliográfica nacional e internacional.

A case of female thoraco omphalopagus conjoined twins is described. Antenatal diagnosis procedures, obstetric management and rational planning by cesarean section with neonatal intesive care facilities are discussed. A review reports national and international is presented.

Assuntos

RESUMO

Se presentan las espátulas rectas y paralelas de Velasco (ERV), se describe el instrumento, sus características y se da a conocer una experiencia preliminar en un período de 3 años entre 1997 y 2000 y los resultados obtenidos en nuestro servicio de parto con fetos expulsivos detenidos y alteraciones de sus latidos cardíaco

Assuntos

RESUMO

A numerical technique is presented for the thermal force exerted on a solid particle by a gaseous medium between two flat plates at different temperatures, in the free molecular or transition flow. This is a two-dimensional molecular-dynamics simulation of hard disks in a inhomogeneous thermal environment. All steady-state features exhibited by the compressible hard-disk gas are shown to be consistent with the expected behaviors. Moreover the thermal force experienced by a large solid disk is investigated, and compared to the analytical case of cylinders moving perpendicularly to the constant temperature gradient for an infinite Knudsen number and in an infinite medium. We show precise examples of how this technique can be used simply to investigate more difficult practical problems, in particluar the influence of nonlinear gradients for large applied differences of temperature, of proximity of the walls, and of smaller Knudsen numbers.

RESUMO

Motivated by recent experiments on phase behavior of systems confined in porous media, we have studied the effect of randomness on the nature of the phase transition in the two-dimensional Potts model. To model the effects of the porous matrix we introduce a random distribution of couplings P(J(ij))=pdelta(J(ij)-J1)+(1-p)delta(J(ij)-J2) in the q state Potts Hamiltonian. An extensive Monte Carlo study is made on this system for q=5. We studied two different cases of disorder (a) J(1)/J(2)-->infinity and p=0.8 and (b) J(1)/J(2)=10 and p=0.5. We observed, in both cases, that the weak first order transition that appears in the pure case, changes to a second-order transition. A finite size scaling analysis shows that the correlation length exponent nu is close to 1 and the best fit to the dependence of the specific heat on system size is logarithmic. This suggests that both cases belong to the universality class of the Ising model. In contrast, the magnetic exponents point to a different universality class.

RESUMO

Estudia restrospectivamente los ingresos al Hospital Pediátrico Baca Ortiz de Quito, con diagnóstico de osteomielitis. Predominaron los casos en el sexo masculino (57xciento); se determinó que las edades de mayor incidencia fueron 7 años (20xciento), 5 años (16.5xciento), 11 años (13.3xciento), 12 años (10xciento) y una distribución para el resto de casos correspondiente a 2 pacientes por cada grupo. El hueso afectado con mayor frecuencia fue la tibia (66.5xciento, n=20) seguido por el fémur (20xciento) y gentamicina en el 10xciento restante (n=3). Los procedimientos quirúrgicos consistieron en secuestrectomía más curetaje en el 93xciento de casos (n=28), colocación de perlas de gentamicina en 16 sujetos (53xciento) e inmovilización en la totalidad de casos.

Assuntos