RESUMO
The aim of the present study was to evaluate the potential antimicrobial activity of 14 plants used in northeast México for the treatment of respiratory diseases, against drug-sensitive and drug-resistant strains of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae type b and Mycobacterium tuberculosis. Forty-eight organic and aqueous extracts were tested against these bacterial strains using a broth microdilution test. No aqueous extracts showed antimicrobial activity, whereas most of the organic extracts presented antimicrobial activity against at least one of the drug-resistant microorganisms tested. Methanol-based extracts from the roots and leaves of Leucophyllum frutescens and ethyl ether extract from the roots of Chrysanctinia mexicana showed the greatest antimicrobial activity against the drug-resistant strain of Mycobacterium tuberculosis; the minimal inhibitory concentration (MIC) were 62.5, 125 and 62.5 microg/mL, respectively; methanol-based extract from the leaves of Cordia boissieri showed the best antimicrobial activity against the drug-resistant strain of Staphylococcus aureus (MIC 250 microg/mL); the hexane-based extract from the fruits of Schinus molle showed considerable antimicrobial activity against the drug-resistant strain of Streptococcus pneumoniae (MIC 62.5 microg/mL). This study supports that selecting plants by ethnobotanical criteria enhances the possibility of finding species with activity against resistant microorganisms.
Assuntos
Antibacterianos/farmacologia , Antituberculosos/farmacologia , Extratos Vegetais/farmacologia , Farmacorresistência Bacteriana Múltipla , Haemophilus influenzae/efeitos dos fármacos , Medicina Tradicional , México , Testes de Sensibilidade Microbiana , Mycobacterium tuberculosis/efeitos dos fármacos , Plantas Medicinais/química , Staphylococcus aureus/efeitos dos fármacos , Streptococcus pneumoniae/efeitos dos fármacosRESUMO
This paper presents a patient with multiple condyloma and a Buschke-Lowenstein tumor in the groin with clinical aspect of a squamous carcinoma. Malignity was histologically ruled out in this case. Lesions were treated by surgery and during the postoperative period, the patient was treated with interferon alpha i.m. at a rate of 9 x 10(6) UI/day three times a week for 3 weeks. One year after the treatment, the patient had not shown any relapse.
Assuntos
Carcinoma de Células Escamosas/diagnóstico , Condiloma Acuminado/diagnóstico , Virilha , Adulto , Antivirais/uso terapêutico , Condiloma Acuminado/tratamento farmacológico , Condiloma Acuminado/cirurgia , Diagnóstico Diferencial , Seguimentos , Humanos , Interferon Tipo I/uso terapêutico , Masculino , Cuidados Pós-Operatórios , Proteínas Recombinantes , Fatores de TempoRESUMO
This is a method to evaluate both specific sensitivity to allergens in the nasal mucosa, IgE-mediated hypersensitivity, and antiinflammatory and antiallergic drugs efficacy, whose objectives are for research in diagnosis and treatment. The method is based in allergen extracts delivery in the nasal mucosa and the post-challenge measurement of rhinitis symptoms, vasoactive mediators release quantification and nasal obstruction degree evaluated by rhinomanometry. Nasal allergen challenge is a procedure of diagnostic and therapeutic evaluation usefulness, that must be performed in selected patients, in adequate facilities, by experts physicians, with standardised allergen dosages, in an specific nasal area, with objective measurements (rhinomanometry, mediators and secretions of the allergic response) and symptoms scoring that allow get reliable results in patients with allergic rhinitis under study.
Assuntos
Alérgenos , Testes de Provocação Nasal , Humanos , Sensibilidade e EspecificidadeRESUMO
We investigated the HIV prevalence rate in 106 female prostitutes residing in Huixtla, State of Chiapas, which is a small town in the southeastern part of Mexico, from February of 1989 to January of 1990. We used an immunoenzymatic method (Serodia). The mean age was 35 years ranging from 17 to 43. Sixty six women (62%) were from Central America, and the remainder had been born in Mexico. The HIV antibody was not detected in the women, but 39 (37%) had a sexually transmitted disease: the more frequent were condolomatosis, candidiasis, trichomoniasis, gonorrhea, and syphilis.
Assuntos
Infecções por HIV/epidemiologia , Trabalho Sexual , Infecções Sexualmente Transmissíveis/epidemiologia , Adolescente , Adulto , Feminino , Humanos , México/epidemiologia , Prevalência , Saúde da População UrbanaRESUMO
Zinc (Zn) and copper (Cu) concentrations were studied in plasma and erythrocytes in patients with chronic renal failure that were on hemo or peritoneal dialysis together with the effect of dialysis treatment on these element concentrations. Plasma Zn was found to be significantly reduced in both groups of patients. On the other hand, erythrocyte zinc levels were higher. This considered more as a metabolic adaptation than as a pathological fact. Plasma Cu increase was observed in hemodialysis patients; however in the group on peritoneal dialysis it was found to be normal. Dialysis did not alter significantly plasma levels in any of these two elements; on the contrary, Zn and Cu levels were decreased in erythrocytes. Ceruloplasmin increased with hemodialysis and decreased with peritoneal dialysis possible due to protein loss resulting in this procedure.
Assuntos
Cobre/sangue , Eritrócitos/análise , Falência Renal Crônica/sangue , Zinco/sangue , Adolescente , Adulto , Ceruloplasmina/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Diálise Peritoneal , Diálise RenalRESUMO
Se estudiaron la concentracion de cinc (Zn) y de cobre (Cu) en el plasma y los eritrocitos de pacientes con insuficiencia renal cronica (IRC) que recebian tratamiento con hemodialisis o dialisis peritoneal, y el efecto que tiene la terapeutica dialitica sobre la concentracion de esos elementos. El Zn plasmatico se encontro significativamente disminuido en los dos grupos de pacientes.En contraste, el Zn del eritrocito estuvo elevado. Esto se interpreta como una adaptacion metabolica mas que como un hecho patologico. Se encontro aumento del Cu plasmatico en los pacientes en hemodialisis; en cambio, en el grupo de dialisis peritoneal fue normal. La dialisis no altero significativamente los niveles plasmaticos de ninguno de los dos elementos; por lo contrario, en el eritrocito se observo una disminucion tanto del Zn como del Cu. La ceruloplasmina se incremento con la hemodialisis y disminuyo con la dialisis peritoneal, posiblemente por la perdida de proteinas que se produce cuando se realiza este procedimiento