RESUMO
OBJECTIVE: To evaluate the hypoglycemic activity of the hexane, chloroform and methanol extracts of Bouvardia terniflora, Brickelia veronicaefolia and Parmentiera edulis. MATERIAL AND METHODS: Normal and alloxan-induced diabetic mice were administered these plant extracts (intraperitoneal 100, 200 and 300 mg/kg). RESULTS: The administration of 300 mg/kg of chloroform extracts from P. edulis and B. terniflora and hexane from B. veronicaefolia to diabetic mice decreased the blood glucose levels in 43.75, 58.56 and 72.13%, respectively. These extracts administered to normal mice reduced blood glucose levels in 29.61, 33.42 and 39.84%, respectively. CONCLUSIONS: The hypoglycemic effect of these plant extracts used in traditional medicine for diabetes treatment is confirmed.
Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Hipoglicemiantes/farmacologia , Aloxano , Animais , Diabetes Mellitus Experimental/induzido quimicamente , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Camundongos , Extratos Vegetais/farmacologiaRESUMO
The purpose of this research was to study the anti-hyperglycemic effect of 28 medicinal plants used in the treatment of diabetes mellitus. Each plant was processed in the traditional way and intragastrically administered to temporarily hyperglycemic rabbits. The results showed that eight out of the 28 studied plants significantly decrease the hyperglycemic peak and/or the area under the glucose tolerance curve. These plants were: Guazuma ulmifolia, Tournefortia hirsutissima, Lepechinia caulescens, Rhizophora mangle, Musa sapientum, Trigonella foenum graceum, Turnera diffusa, and Euphorbia prostrata. The results suggest the validity of their clinical use in diabetes mellitus control, after their toxicological investigation.