RESUMO
Intermediate and highly malignant non-Hodgkin and primary central nervous system lymphomas are marker diseases for AIDS. Cavum and oropharynx involvement by these tumors is uncommon. Although there are few cases reported in the literature, these may be primary localizations of the tumor. We present a hemophilic HIV+ patient with non-Hodgkin lymphoma of the cavum. The histologic diagnosis was high-grade, pleomorphic, centroblastic lymphoma. The patient was treated with chemotherapy plus intrathecal chemotherapy and highly active antiretroviral therapy (HAART). His evolution has been excellent. One year after diagnosis, the patient is asymptomatic with no evidence of residual tumor, and responding well to HAART.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Hemofilia A/complicações , Linfoma Relacionado a AIDS/diagnóstico , Linfoma não Hodgkin/diagnóstico , Neoplasias Nasofaríngeas/diagnóstico , Adulto , Humanos , Linfoma Relacionado a AIDS/complicações , Linfoma Relacionado a AIDS/tratamento farmacológico , Linfoma não Hodgkin/complicações , Linfoma não Hodgkin/tratamento farmacológico , Masculino , Neoplasias Nasofaríngeas/complicações , Neoplasias Nasofaríngeas/tratamento farmacológico , Tomografia Computadorizada por Raios XRESUMO
Intermediate and highly malignant non-Hodgkin and primary central nervous system lymphomas are marker diseases for AIDS. Cavum and oropharynx involvement by these tumors is uncommon. Although there are few cases reported in the literature, these may be primary localizations of the tumor. We present a hemophilic HIV+ patient with non-Hodgkin lymphoma of the cavum. The histologic diagnosis was high-grade, pleomorphic, centroblastic lymphoma. The patient was treated with chemotherapy plus intrathecal chemotherapy and highly active antiretroviral therapy (HAART). His evolution has been excellent. One year after diagnosis, the patient is asymptomatic with no evidence of residual tumor, and responding well to HAART.
RESUMO
Serologic reactivity against EBV-infected lines was assayed in patients with AIDS (n = 4) or the AIDS related complex (AIDS-RC) (n = 46) residing in Argentina. Anti-VCA serology was comparable to that of controls. However sera from AIDS and AIDS-RC could induce antibody dependent cell mediated cytotoxicity (ADCC) to EBV-infected cell lines (P3HRIK and Raji). ADCC activity could be recovered in the high molecular weight fractions of AIDS and AIDS-RC sera. ADCC was observed in sera with high levels of PEG precipitable material (PEG-pp) but was unrelated to the presence of complement-fixing immune complexes (Clq-F) or to anti-VCA titers. Fc receptor (FcR) bridging between target cells FcR and effector cells FcR may play a role in the outcome of total ADCC.
Assuntos
Complexo Relacionado com a AIDS/imunologia , Síndrome da Imunodeficiência Adquirida/imunologia , Citotoxicidade Celular Dependente de Anticorpos , Proteínas do Capsídeo , Herpesvirus Humano 4/imunologia , Complexo Relacionado com a AIDS/sangue , Síndrome da Imunodeficiência Adquirida/sangue , Anticorpos Antivirais/imunologia , Complexo Antígeno-Anticorpo/análise , Antígenos Virais/imunologia , Linfoma de Burkitt/patologia , Linhagem Celular , Enzimas Ativadoras do Complemento/análise , Complemento C1/análise , Complemento C1q , Humanos , Masculino , Receptores Fc/imunologia , Células Tumorais CultivadasRESUMO
Serologic reactivity against EBV-infected lines was assayed in patients with AIDS (n = 4) or the AIDS related complex (AIDS-RC) (n = 46) residing in Argentina. Anti-VCA serology was comparable to that of controls. However sera from AIDS and AIDS-RC could induce antibody dependent cell mediated cytotoxicity (ADCC) to EBV-infected cell lines (P3HRIK and Raji). ADCC activity could be recovered in the high molecular weight fractions of AIDS and AIDS-RC sera. ADCC was observed in sera with high levels of PEG precipitable material (PEG-pp) but was unrelated to the presence of complement-fixing immune complexes (Clq-F) or to anti-VCA titers. Fc receptor (FcR) bridging between target cells FcR and effector cells FcR may play a role in the outcome of total ADCC.