RESUMO

The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.

Assuntos

Bile/metabolismo , Fístula Biliar/tratamento farmacológico , Fístula/tratamento farmacológico , Octreotida/uso terapêutico , Dermatopatias/tratamento farmacológico , Adulto , Fístula Biliar/fisiopatologia , Preparações de Ação Retardada , Fístula/fisiopatologia , Humanos , Masculino , Dermatopatias/fisiopatologia