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There is growing evidence about how physical activity can improve cancer care. Unfortunately, exercise is still not widely prescribed to oncology patients, despite the benefit it brings. For this to occur, it is necessary for a multidisciplinary approach involving different types of healthcare professionals, given that each treatment be tailored for each single case. Besides incorporating appropriate infrastructures and referral pathways, we need to integrate exercise into healthcare practice, which ameliorates patients' quality of life and treatment side effects. From the Spanish Society of Medical Oncology (SEOM), and through the Exercise and Cancer Working Group, we indicate considerations, analyze patient care scenarios, and propose a referral pathway algorithm for exercise prescription, taking in account the patient's needs. In later sections of this paper, we describe how this algorithm could be implemented, and how the exercise programs should be built, including the physical activity contents, the settings, and the delivery mode. We conclude that professionals, infrastructures, and organizations should be available at every assistance level to create programs providing adequate exercise training for cancer patients.
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It has been well established that a consolidated memory can be updated during the plastic state induced by reactivation. This updating process opens the possibility to modify maladaptive memory. In the present study, we evaluated whether fear memory could be updated to less-aversive level by incorporating hedonic information during reactivation. Thus, male rats were fear conditioned and, during retrieval, a female was presented as a social rewarding stimulus. We found that memory reactivation with a female (but not a male) reduces fear expression within-session and in the test, without presenting reinstatement or spontaneous recovery. Interestingly, this intervention impaired extinction. Finally, we demonstrated that this emotional remodeling to eliminate fear expression requires the activation of dopamine and oxytocin receptors during retrieval. Hence, these results shed new lights on the memory updating process and suggests that the exposure to natural rewarding information such as a female during retrieval reduces a previously consolidated fear memory.
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Medo , Receptores de Ocitocina , Interação Social , Animais , Medo/fisiologia , Masculino , Ratos , Receptores de Ocitocina/metabolismo , Feminino , Memória/fisiologia , Extinção Psicológica/fisiologia , Receptores Dopaminérgicos/metabolismo , Condicionamento Clássico/fisiologia , Recompensa , Ratos Wistar , Consolidação da Memória/fisiologiaRESUMO
Importance: Standard of care for unresectable locally advanced non-small cell lung cancer (NSCLC) involves definitive chemoradiotherapy followed by maintenance therapy with durvalumab. However, the cost of durvalumab has been cited as a barrier to its use in various health systems. Objective: To evaluate the cost-effectiveness of durvalumab vs placebo as maintenance therapy in patients with unresectable stage III NSCLC from 4 international payer perspectives (US, Brazil, Singapore, and Spain). Design, Setting, and Participants: In this economic evaluation, a Markov model was designed to compare the lifetime cost-effectiveness of maintenance durvalumab for unresectable stage III NSCLC with that of placebo, using 5-year outcomes data from the PACIFIC randomized placebo-controlled trial. Individual patient data were extracted from the PACIFIC, KEYNOTE-189, ADAURA, ALEX, and REVEL randomized clinical trials to develop a decision-analytic model to determine the cost-effectiveness of durvalumab compared with placebo maintenance therapy over a 10-year time horizon. Direct costs, adverse events, and patient characteristics were based on country-specific payer perspectives and demographic characteristics. The study was conducted from June 1, 2022, through December 27, 2023. Main Outcomes and Measures: Life-years, quality-adjusted life years (QALYs), lifetime costs, and incremental cost-effectiveness ratios (ICERs) were estimated at country-specific willingness-to-pay thresholds ([data reported in US$] US: $150â¯000 per QALY; Brazil: $22â¯251 per QALY; Singapore: $55â¯288 per QALY, and Spain: $107â¯069 per QALY). One-way and probabilistic sensitivity analyses were performed to account for parameters of uncertainty. A cost-threshold analysis was also performed. Results: The US base-case model found that treatment with durvalumab was associated with an increased cost of $114â¯394 and improved effectiveness of 0.50 QALYs compared with placebo, leading to an ICER of $228â¯788 per QALY. Incremental cost-effectiveness ratios, according to base-case models, were $141â¯146 for Brazil, $153â¯461 for Singapore, and $125â¯193 for Spain. Durvalumab price adjustments to the PACIFIC data improved cost-effectiveness in Singapore, with an ICER of $45â¯164. The model was most sensitive to the utility of durvalumab. Conclusions and Relevance: In this cost-effectiveness analysis of durvalumab as maintenance therapy for unresectable stage III NSCLC, the therapy was found to be cost-prohibitive from the perspective of various international payers according to country-specific willingness-to-pay thresholds per QALY. The findings of the study suggest that discounted durvalumab acquisition costs, as possible in Singapore, might improve cost-effectiveness globally.
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Anticorpos Monoclonais , Carcinoma Pulmonar de Células não Pequenas , Análise Custo-Benefício , Neoplasias Pulmonares , Humanos , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/economia , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/economia , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais/economia , Brasil , Espanha , Anos de Vida Ajustados por Qualidade de Vida , Masculino , Singapura , Feminino , Estados Unidos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Idoso , Antineoplásicos Imunológicos/uso terapêutico , Antineoplásicos Imunológicos/economia , Cadeias de Markov , Análise de Custo-EfetividadeRESUMO
We evaluate depletion forces in molecular dynamics simulation of a binary mixture of spheres (depleted particles) and rods (depletant particles) for a wide range of densities for both species. This evaluation was carried out using a recently proposed least squares fitting algorithm. We found that the restriction of the rods' rotational degrees of freedom, when the distance between two spheres is less than the rods length, creates a shallow, and apparently linear, attractive force ramp. For intersphere distances smaller than the rods' diameter, a much stronger attractive force is found, and a large repulsive barrier appears between these aforementioned regimes, roughly at the distance of the rods' thickness. The evaluated forces are validated via a comparison of the pairwise correlation functions obtained from molecular dynamics simulation of a mono-disperse sphere fluid, using the evaluated effective forces, against the original (full system) pairwise correlation functions. Agreement is excellent. We also record the angular pairwise correlation function, using the P2(x) Legendre polynomial, and find that for high densities of both species, a local nematic ordering starts to appear. This nematic order may be a factor in the small differences found between original and effective pairwise correlation functions at high densities of rods.
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During the last few years, patchy colloidal dispersions have emerged as ideal candidates of glass-formers of systems composed of particles that interact with non-isotropic potentials. However, from the computational point of view, the characterization of their dynamical properties close to the glass transition via any kind of molecular dynamics simulation technique can be very difficult due to the slowing down of both the rotational and translational dynamics. Although a plethora of dynamical techniques have been developed to account for the dynamics of patchy colloids, new and complementary simulation techniques are required to explore, much faster and more efficiently, the dynamical arrest transition of patchy colloidal dispersions when computer simulation consists of a large number of particles and, due to the slow particle dynamics at the glass transition, an extended time window is explicitly required. Then, in this contribution, by means of the so-called dynamic-Monte Carlo method, we report on the dynamical arrest transition, both rotational and translational, of a bidisperse patchy colloidal dispersion, following three different paths along the density-temperature plane, including high densities and low temperatures. Although this method has not been extensively tested at extreme thermodynamic conditions, we show that even at the dynamical arrest transition, it allows us to extract good dynamical data from a complex system. Therefore, it turns out to be a promising technique to explore the onset of vitrification of anisotropic colloidal particles.
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We carried out a theoretical and numerical analysis for an epidemic model to analyze the dynamics of the SARS-CoV-2 Omicron variant and the impact of vaccination campaigns in the United States. The model proposed here includes asymptomatic and hospitalized compartments, vaccination with booster doses, and the waning of natural and vaccine-acquired immunity. We also consider the influence of face mask usage and efficiency. We found that enhancing booster doses and using N95 face masks are associated with a reduction in the number of new infections, hospitalizations and deaths. We highly recommend the use of surgical face masks as well, if usage of N95 is not a possibility due to the price range. Our simulations show that there might be two upcoming Omicron waves (in mid-2022 and late 2022), caused by natural and acquired immunity waning with respect to time. The magnitude of these waves will be 53% and 25% lower than the peak in January 2022, respectively. Hence, we recommend continuing to use face masks to decrease the peak of the upcoming COVID-19 waves.
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COVID-19 , Estados Unidos/epidemiologia , Humanos , COVID-19/epidemiologia , COVID-19/prevenção & controle , SARS-CoV-2 , Imunidade Adaptativa , VacinaçãoRESUMO
It has been shown that a previously consolidated memory can incorporate either new external information or a novel internal emotional state following a labile state induced by retrieval. This updating process allows editing unwanted fear memory, leading to the reduction of the fear response. Memory can be modulated by the circadian cycle. Considering that rodents are more active during the night, expressing less fearful behavior, we investigated whether fear memory can be updated when reactivated during the dark cycle. We found that rats expressed lower freezing levels during a single retrieval session in the dark cycle, but not in the test. However, three retrieval sessions in the dark cycle were able to update fear memory, reducing freezing response in the test performed in the light cycle. This effect was blocked when the glucocorticoid synthesis inhibitor metyrapone was administered before retrieval. This approach opens new avenues to explore interventions that consider the circadian cycle in the treatment of fear memories based on non-pharmacological interventions.
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Medo , Glucocorticoides , Animais , Ratos , Glucocorticoides/farmacologia , Medo/fisiologia , Extinção Psicológica/fisiologiaRESUMO
Depletion forces are fundamental for determining the phase behavior of a vast number of materials and colloidal dispersions and have been used for the manipulation of in- and out-of-equilibrium thermodynamic states. The entropic nature of depletion forces is well understood; however, most theoretical approaches, and also molecular simulations, work quantitatively at moderate size ratios in much diluted systems since large size asymmetries and high particle concentrations are difficult to deal with. The existing approaches for integrating out the degrees of freedom of the depletant species may fail under these extreme physical conditions. Thus, the main goal of this contribution is to introduce a general physical formulation for obtaining the depletion forces even in those cases where the concentration of all species is relevant. We show that the contraction of the bare forces uniquely determines depletion interactions. Our formulation is tested by studying depletion forces in binary and ternary colloidal mixtures. We report here results for dense systems with total packing fractions of 45% and 55%. Our results open up the possibility of finding an efficient route to determine effective interactions at a finite concentration, even under non-equilibrium thermodynamic conditions.
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Entropia , TermodinâmicaRESUMO
Purpose: Despite newer type 2 diabetes (T2D) medications, patients do not always achieve metabolic targets, remaining at risk for cardiorenal complications. Therapeutic decisions are generally made by the healthcare team without considering patients' preferences. We aimed to evaluate patients' T2D treatment preference in two Latin-American countries between two different oral medication profiles, one resembling dipeptidyl peptidase-4 inhibitors (DPP4i) and another resembling sodium-glucose cotransporter-2 inhibitors (SGLT2i). Patients and Methods: In this cross-sectional, multicenter study from June to September 2020, patients with T2D from Argentina and Mexico (n = 390) completed a discrete choice experiment questionnaire to identify preferences between DPP4i (medication profile A) and SGLT2i (medication profile B). The reason behind patients' choice, and the association between their baseline characteristics and their preference were evaluated using logistic regression methods. Results: Most participants (88.2%) preferred SGLT2i's profile. Participants with older age (p = 0.0346), overweight or obesity (p < 0.0001), high blood pressure (BP; p < 0.0001), high total cholesterol (p = 0.0360), and glycosylated hemoglobin (HbA1c) <7% (p = 0.0001) were more likely to choose SGLT2i compared with DPP4i's profile. The most and least important reasons to choose either drug profile were HbA1c reduction and genital infection risk, respectively. The likelihood of selecting the SGLT2i's profile significantly increased in participants with increased body mass index (BMI; odds ratio [OR] = 8.9, 95% confidence interval [CI]: 3.5-22.5, p < 0.05), high BP (OR = 4.9, 95% CI: 1.9-12.4, p < 0.05), and lower education level (OR = 3.6, 95% CI: 1.0-12.6, p < 0.05). Conclusion: Latin-American patients with T2D preferred medication with a profile resembling SGLT2i over one resembling DPP4i as a treatment option. A patient-centered approach may aid the healthcare team in decision-making for improved outcomes.
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In this paper, we study a diffusive SIRS-type epidemic model with transfer from the infectious to the susceptible class. Our model includes a general nonlinear incidence rate and spatially heterogeneous diffusion coefficients. We compute the basic reproduction number R 0 of our model and establish the global stability of the disease-free steady state when R 0 < 1 . Furthermore, we study the uniform persistence when R 0 > 1 and perform a bifurcation analysis for a special case of our model. Some numerical simulations are presented to illustrate the dynamics of the solutions as the model parameters are varied.
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The recently developed non-equilibrium self-consistent generalized Langevin equation theory of the dynamics of liquids of non-spherically interacting particles [2016J. Phys. Chem. B1207975] is applied to the description of the irreversible relaxation of a thermally and mechanically quenched dipolar fluid. Specifically, we consider a dipolar hard-sphere liquid quenched (attw= 0) from full equilibrium conditions towards different ergodic-non-ergodic transitions. Qualitatively different scenarios are predicted by the theory for the time evolution of the system after the quench (tw> 0), that depend on both the kind of transition approached and the specific features of the protocol of preparation. Each of these scenarios is characterized by the kinetics displayed by a set of structural correlations, and also by the development of two characteristic times describing the relaxation of the translational and rotational dynamics, allowing us to highlight the crossover from equilibration to aging in the system and leading to the prediction of different underlying mechanisms and relaxation laws for the dynamics at each of the glass transitions explored.
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Depletion interactions between colloidal particles surrounded by smaller depletants are typically characterized by a strong attraction at contact and a moderately repulsive barrier in front of it that extends at distances similar to the size of the depletants; the appearance and height of the barrier basically depend on the concentration and, therefore, the correlation between depletants. From a thermodynamic point of view, the former can drive the system to phase separation or toward non-equilibrium states, such as gel-like states, but its effects on both local and global properties may be controlled by the latter, which acts as a kind of entropic gate. However, the latter has not been entirely analyzed and understood within the context of colloidal mixtures mainly driven by entropy. In this contribution, we present a systematic study of depletion forces in ternary mixtures of hard spherical particles with two species of depletants, in two and three dimensions. We focus the discussion on how the composition of the depletants becomes the main physical parameter that drives the competition between the attractive well and the repulsive barrier. Our results are obtained by means of the integral equation theory of depletion forces and techniques of contraction of the description adapted to molecular dynamics computer simulations.
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RESUMEN Introducción: durante los tres primeros años de vida, las funciones bucofaríngeas se atribuyen a factores genéticos y ambientales. Objetivo: caracterizar las funciones bucofaríngeas en el segundo y tercer año de vida, en niños del municipio de Santa Clara, provincia Villa Clara. Métodos: se realizó un estudio descriptivo, longitudinal y prospectivo, en el período de octubre de 2014 a junio de 2017. El universo de estudio estuvo constituido por todos los niños nacidos en el Hospital Universitario Ginecobstétrico «Mariana Grajales¼ de Santa Clara, en abril y mayo de 2013, pertenecientes a cualquier área de salud de dicho municipio. La muestra estuvo integrada por 64 niños que fueron examinados a los 18, 24, 30 y 36 meses de edad. Para la recolección de los datos se aplicó el método de observación; la información obtenida se procesó y se sometió a pruebas estadísticas. Resultados: las funciones bucofaríngeas, excepto la fonatoria, sufrieron un deterioro progresivo según aumentó la edad de los niños observados; así mismo, aparecieron hábitos de respiración bucal y deglución con protracción exagerada. Conclusiones: se produjeron importantes cambios en las funciones bucofaríngeas en el segundo y tercer año de vida, en los niños integrantes de la cohorte estudiada.
ABSTRACT Introduction: oropharyngeal functions are attributed to genetic and environmental factors during the first three years of life. Objective: to characterize oropharyngeal functions in the second and third year of life, in children from Santa Clara municipality, Villa Clara province. Methods: a prospective, longitudinal and descriptive study was carried out from October 2014 to June 2017. The study universe consisted of all the children born at "Mariana Grajales" Gynecology and Obstetrics University Hospital in Santa Clara, in April and May 2013, belonging to the health areas of the mentioned municipality. The sample consisted of 64 children who were examined at 18, 24, 30 and 36 months of age. Observation method was applied for data collection; the obtained information was processed and subjected to statistical tests. Results: oropharyngeal functions, with the exception of phonatory, suffered a progressive deterioration as the age of the observed children increased; likewise, mouth breathing and swallowing habits with exaggerated protraction appeared. Conclusions: important changes in oropharyngeal functions during the second and third year of life were observed in children belonging to the studied cohort.
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FaringeRESUMO
We propose an SEIARD mathematical model to investigate the current outbreak of coronavirus disease (COVID-19) in Mexico. Our model incorporates the asymptomatic infected individuals, who represent the majority of the infected population (with symptoms or not) and could play an important role in spreading the virus without any knowledge. We calculate the basic reproduction number (R 0) via the next-generation matrix method and estimate the per day infection, death and recovery rates. The local stability of the disease-free equilibrium is established in terms of R 0. A sensibility analysis is performed to determine the relative importance of the model parameters to the disease transmission. We calibrate the parameters of the SEIARD model to the reported number of infected cases, fatalities and recovered cases for several states in Mexico by minimizing the sum of squared errors and attempt to forecast the evolution of the outbreak until November 2020.
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RESUMO A odontodisplasia regional é uma anomalia dentária, pouco comum, não hereditária e com uma etiologia ainda desconhecida. Os tecidos afetados são o esmalte e a dentina, são acometidos nos dentes decíduos e, as vezes na dentição permanente de um mesmo indivíduo. Esta lesão pode ser confundida com outras lesões como por exemplo o odontoma ou dentes com outro tipo de anomalia. O objetivo é relatar um caso de odontodisplasia regional na dentição decídua e permanente de uma criança, assim como apresentar as diferentes ferramentas diagnósticas. Os dentes acometidos mostravam-se ao exame clínico, como dentes hipoplásicos com coloração amarelo amarronzado. Uma radiografia panorâmica e radiografias periapicais, assim como uma biopsia excisional, foram essenciais para obter um diagnóstico correto, e assim poder oferecer uma adequada conduta para a preservação e previsibilidade dos diferentes tipos de tratamentos reabilitadores odontológicos que essa criança poderia ter nos próximos anos até a idade adulta.
SUMMARY Regional odontodysplasia is an uncommon dental anomaly that is not hereditary and has a still unknown etiology. The affected tissues are enamel and dentin, the primary teeth are affected, and sometimes in the permanent dentition of the same individual. This lesion may be confused with other lesions such as odontoma or teeth with another type of anomaly. The objective is to report a case of regional odontodysplasia in the deciduous and permanent dentition of a child, as well as to present the different diagnostic tools. The affected teeth showed clinical examination, such as hypoplastic teeth with a yellow-brown coloration. A panoramic radiograph and periapical radiographs, as well as an excisional biopsy, were essential to obtain a correct diagnosis, so as to be able to offer an adequate conduct for the preservation and predictability of the different types of dental rehabilitation treatments that this child could have in the years to come adulthood.
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In the last decade it became clear that a previously consolidated memory can be modified during the plastic state induced by retrieval. This updating process opens the possibility to adapt undesired memory. Here we investigated whether fear memory could be updated to less-aversive/positive level by inserting hedonic information during retrieval. Considering that methylphenidate has strong rewarding propriety, we injected 3 or 10 mg/kg pre or post-reactivation in rats previously trained in contextual fear conditioning. We found that memory reactivation under effect of methylphenidate attenuates fear memory within-session and in subsequent tests in a drug-free condition, without presenting spontaneous recovery. Interestingly, methylphenidate impaired memory extinction when injected before, but not after a long reactivation session. We also showed that methylphenidate induces place preference and increases motor activity. Thus, this study provides new insights in the memory updating process and suggests that a previously consolidated fear memory can be attenuated by inserting appetitive information during retrieval.
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Estimulantes do Sistema Nervoso Central/farmacologia , Medo/efeitos dos fármacos , Medo/psicologia , Memória/efeitos dos fármacos , Metilfenidato/farmacologia , Recompensa , Animais , Condicionamento Operante/efeitos dos fármacos , Condicionamento Psicológico/efeitos dos fármacos , Extinção Psicológica/efeitos dos fármacos , Masculino , Consolidação da Memória , Rememoração Mental/efeitos dos fármacos , Atividade Motora/efeitos dos fármacos , Prazer , Ratos , Ratos WistarRESUMO
The eradication of hepatitis C virus (HCV) infection is a public health priority. Despite the efficiency of treatment with direct-acting antivirals, the high cost of the therapy and the lack of accurate data about the HCV-infected population worldwide constitute important factors hampering this task. Hence, an affordable preventive vaccine is still necessary for reducing transmission and the future disease burden globally. In this work, chimeric proteins (EnvCNS3 and NS3EnvCo) encompassing conserved and immunogenic epitopes from the HCV core, E1, E2 and NS3 proteins were produced in Escherichia coli, and their immunogenicity was evaluated in BALB/c mice. The impact of recombinant HCV E2.680 protein and oligodeoxynucleotide 39M (ODN39M) on the immune response to chimeric proteins was also assessed. Immunization with chimeric proteins mixed with E2.680 enhanced the antibody and cellular response against HCV antigens and chimeric proteins. Interestingly, the combination of NS3EnvCo with E2.680 and ODN39M as adjuvant elicited a potent antibody response characterized by an increase in antibodies of the IgG2a subclass against E2.680, NS3 and chimeric proteins, suggesting the induction of a Th1-type response. Moreover, a cytotoxic T lymphocyte response and a broad response of IFN-γ-secreting cells against HCV antigens were induced with this formulation as well. This T cell response was able to protect vaccinated mice against challenge with a surrogate model based on HCV recombinant vaccinia virus. Overall, the vaccine candidate NS3EnvCo/E2.680/ODN39M might constitute an effective immunogen against HCV with potential for reducing the likelihood of viral persistence.
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Hepacivirus/imunologia , Anticorpos Anti-Hepatite C/sangue , Proteínas Recombinantes/imunologia , Sequência de Aminoácidos , Animais , Linfócitos T CD4-Positivos , Clonagem Molecular , Epitopos , Feminino , Regulação da Expressão Gênica/imunologia , Antígenos da Hepatite C/imunologia , Imunidade Celular , Interferon gama/genética , Interferon gama/metabolismo , Interleucina-4/genética , Interleucina-4/metabolismo , Camundongos , Camundongos Endogâmicos BALB C , PlasmídeosRESUMO
OBJECTIVES: This study investigated the association of congenital cervical vertebrae anomalies (CVA) with the prevalence of cleft lip and palate (CLP) specifying the most frequent associations. METHODS: A meta-analysis was based on the Preferred Reporting Items of Systematic reviews and Meta-Analyses guideline. A search of the PubMed, Embase, Web of Science, Science Direct, Scopus and Lilacs database was performed until March 2018. Clinical studies that evaluated CVA in individuals with CLP (experimental group) and without CLP (control group) was included. For the statistical analysis, the software Comprehensive Meta-Analysis (Biostat; Englewood, NJ) was used, with a p-value < 0.05 considered significant. RESULTS: A total of 10 articles were included, for a total of 2566 individuals with CLP and 2301 individuals without CLP. The meta-analysis indicated statistically significant differences and the group of individuals with CLP had an increased number of CVA when compared to the group of individuals without CLP (p < 0.05; 95% confidence interval, 2.41-6.11; heterogeneity: Q-value 32.8, I2 72.6%). CONCLUSIONS: This study indicated that CVA are associated with the presence of CLP. Among the patients with CVA the most frequent anomalies were the deficiency of the posterior arch, followed by the fusion of cervical vertebrae. Individuals with cleft palate and those with unilateral cleft lip and palateCLP had an increased prevalence of CVA.
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Vértebras Cervicais , Fenda Labial , Fissura Palatina , Vértebras Cervicais/anormalidades , Fenda Labial/complicações , Fissura Palatina/complicações , Humanos , PrevalênciaRESUMO
We perform a systematic and detailed study of the glass transition in highly asymmetric binary mixtures of colloidal hard spheres, combining differential dynamic microscopy experiments, event-driven molecular dynamics simulations, and theoretical calculations, exploring the whole state diagram and determining the self-dynamics and collective dynamics of both species. Two distinct glassy states involving different dynamical arrest transitions are consistently described, namely, a double glass with the simultaneous arrest of the self-dynamics and collective dynamics of both species, and a single glass of large particles in which the self-dynamics of the small species remains ergodic. In the single-glass scenario, spatial modulations in the collective dynamics of both species occur due to the structure of the large spheres, a feature not observed in the double-glass domain. The theoretical results, obtained within the self-consistent generalized Langevin equation formalism, are in agreement with both simulations and experimental data, thus providing a stringent validation of this theoretical framework in the description of dynamical arrest in highly asymmetric mixtures. Our findings are summarized in a state diagram that classifies the various amorphous states of highly asymmetric mixtures by their dynamical arrest mechanisms.
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Objetivo: avaliar a eficácia do levantamento do seio maxilar atraumático sem enxerto ósseo e a taxa de sobrevivência da instalação de implantes imediatos. Material e métodos: realizou-se uma estratégia de busca nas bases de dados Pubmed, Web of Science e Science Direct, obtendo 103 artigos, sendo selecionados 07 estudos publicados entre 2008 até 2019. Resultados: foram registrados 576 pacientes com idades entre 19 e 85 anos de idade, de ambos os sexos e 1,113 implantes instalados. Verificou-se uma taxa de sucesso e sobrevivência dos implantes de 96,6%, após um seguimento de 1 a 3 anos e houve um ganho ósseo de aproximadamente 3mm. Considerações finais: o levantamento de seio maxilar atraumático sem enxerto ósseo é eficaz para reabilitação de áreas edêntulas e mostra um bom resultado ao longo do tempo, com uma taxa média de sobrevivência dos implantes de 96,3%. Ainda faltam estudos para determinar qual tipo de implante é melhor para este tipo de técnica. (AU)
Objective: To assess the efficacy of atraumatic maxillary sinus augmentation without bone grafting and the survival rate of the immediate implant installation. Material and methods: A search strategy was performed the in Pubmed, Web of Science, and Science Direct databases, resulting in 103 articles from which seven studies published between 2008 and 2019 were selected. Results: 576 patients of both sexes, aged between 19 and 85 years, were registered, as well as 1,113 implants installed. There was a success rate and survival of implants of 96.6% after a follow-up of 1 to 3 years and there was a bone gain of approximately 3 mm. Final considerations: The atraumatic maxillary sinus augmentation without bone graft is effective to rehabilitate edentulous areas and shows a good outcome over time, with an average rate of implant survival 96.3%. Further studies are still required to determine which type of implant is best for this type of technique.(AU)