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J Pediatr Endocrinol Metab ; 16(8): 1165-73, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14594177

RESUMO

This was a prospective, longitudinal and descriptive study of 117 Mexican girls with Turner's syndrome (TS) followed from diagnosis to 18 years old. Height, weight and growth velocity were evaluated every 4-6 months, and bone age was assessed annually. Adult height was reached in 87 girls. All the girls were treated during 1 year with conjugated estrogens at bone age of 12 years, and subsequently with mixed estrogen/progestogen. Growth retardation in girls with TS is apparent at birth (2.7 +/- 0.9 kg and 46.3 +/- 5.0 cm) and in childhood, but becomes most marked when puberty would normally occur. Mean growth velocity was less than 25th percentile from birth to 2 years, less than 10th percentile between 3-9 years, and less than 3rd percentile from 10 to 18 years of age. Final adult height was 136.9 +/- 5.5 cm, but it is affected by the particular karyotype: 46,Xi(Xq): 134.5 cm, 45,XO: 137.3 cm, and 45XO/46,XX: 139 cm.


Assuntos
Estatura/etnologia , Estatura/genética , Crescimento/genética , Síndrome de Turner/genética , Síndrome de Turner/fisiopatologia , Determinação da Idade pelo Esqueleto/métodos , Estatura/efeitos dos fármacos , Cromossomos Humanos X/genética , Estudos de Coortes , Esquema de Medicação , Estrogênios/uso terapêutico , Estrogênios Conjugados (USP)/uso terapêutico , Feminino , Retardo do Crescimento Fetal/etnologia , Retardo do Crescimento Fetal/genética , Crescimento/efeitos dos fármacos , Humanos , Cariotipagem , México , Progesterona/uso terapêutico , Puberdade/genética , Aberrações dos Cromossomos Sexuais/estatística & dados numéricos , Fatores Socioeconômicos , Síndrome de Turner/tratamento farmacológico
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