1.
ACS Med Chem Lett
; 10(1): 137-141, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30655961
RESUMO
Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well as liver stage are presented. The synthesis, parasitological characterization, physicochemical properties, in vivo evaluation, and mice pharmacokinetics are described.