RESUMO
The emergence of resistant strains of Plasmodium falciparum and Mycobacterium tuberculosis underscores the need for novel drugs that are effective against these microorganisms. As part of our screening programme of the flora of Puerto Rico, we tested a number of ethanol extracts of higher plants for antiplasmodial and antimycobacterial activities. A total of 40 extracts belonging to 23 plant families and 37 species were tested for antiplasmodial activity. Five extracts demonstrated activity against Plasmodium falciparum in vitro (50%-100% parasite suppression at 5 microg/mL). Another 63 extracts belonging to 30 plant families and 50 species were tested in vitro against Mycobacterium tuberculosis. Two extracts were found to be active, Ficus citrifolia and Pisonia borinquena (85% or more inhibition of microbial growth at 100 microg/mL of extract).
Assuntos
Antimaláricos/farmacologia , Antituberculosos/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/farmacologia , Plantas Medicinais , Plasmodium falciparum/efeitos dos fármacos , Animais , Antimaláricos/uso terapêutico , Antituberculosos/uso terapêutico , Humanos , Medicina Tradicional , Testes de Sensibilidade Microbiana , Testes de Sensibilidade Parasitária , Extratos Vegetais/uso terapêutico , Estruturas Vegetais , Porto RicoRESUMO
We report a free-floating left atrial thrombus detected by 2-dimensional echocardiography in a patient with hypertrophic cardiomyopathy. Two-dimensional echocardiography permitted definitive diagnosis, thereby indicating emergency cardiac surgery. To our knowledge, this is the first reported detection of a free-floating left atrial thrombus by 2-dimensional echocardiography in a patient with hypertrophic cardiomyopathy.
RESUMO
The following report presents M-mode and two-dimensional echocardiographic findings in a case of mitral valve aneurysm. M-mode echocardiography showed abnormal intravalvular echoes during diastole and a linear echo in the left atrium, with a motion pattern similar to that of the anterior mitral valve leaflet. By allowing visualization of the aneurysmal sac, two-dimensional echocardiography proved to be a more specific diagnostic method.