RESUMO

Background: Malignant tumors are the main cause of death or euthanasia in animals. The oral cavity ranking fourth in number of occurrences. Epidemiological studies with dogs suggest that canine cancer kills 40-50% of individuals aged over 10 years. In view of the interest of academics and professionals in the healthcare of dogs and cats, this paper reports the case of a 10-month-old bitch, which, despite being a young animal, was affected alveolar rhabdomyosarcoma of abrupt evolution. Case: A 10-month-old French Bulldog bitch, weighing 10 kg, was referred to a veterinary hospital in the city of Rio de Janeiro for care. It had a history of mouth bleeding, after chewing a solid mineral material, edema in the region of the right maxilla, and protusion of the gland of the third eyelid. As the clinical examination also revealed a fracture of the maxillary canine, anti-inflammatory and antibiotics were prescribed, to be administered by the owner once a day for 7 days. During the next clinical examination, carried out one week later, an edema was found in the right region of the mouth, which proved difficult to examine. As the patient had already eaten, an appointment was made for the following day for an intervention in the operating room, where the animal could be anesthetized for better observation of the effected region. Blood was collected for hemogram, urea, creatinine, alkaline phosphatase, ALT, and GGT, and an 8 h food fasting and a 4 h water fasting were recommended. On that date, once the dog had been taken to the operating room, was administered the pre anesthesia, in addition to anesthetic induction and manutention. Upon examining the oral cavity, several loose molars were found on the right side, in addition to a tumoral aspect of the gum; thus, it was decided to collect a small sample of the tumoral mass for histopathology. The surgical specimen was placed in a formalin solution and sent to the laboratory for histopathological processing and diagnosis. One week later, the tumor mass was larger and the edema in the right region of the mouth was much larger than on the day of the procedure. Thus, a computerized tomography was requested to further investigate the alterations that had occurred in such a short time. Due to the results of the histopathology and the CT, an immunohistochemical test was suggested which determined the cell profile and morphology and confirmed the diagnosis of alveolar rhabdomyosarcoma according to clinical suspicion. The animal remained in the veterinary hospital for a further 48 h, during which the clinical condition worsened, with the animal suffering heavy bleeding. As the patient was no longer capable of oral intake of food or water, the decision was made with the consent of the owners to induce a painless death to alleviate the suffering of the animal. However, the owners did not authorize a necropsy. Discussion: Veterinary physicians should be conscious of the treatment of serious illnesses that will not result in a benefit for the patient. They should know when to stop the treatment to not cause further pain and suffering to the animals and their owners. Many of the interventions which aim to treat severe malignant neoplasia will not promote an improvement in quality of life or significantly extend the patient's survival, and do not justify the suffering they entail. A painless death remains the best alternative in such cases.

Assuntos

RESUMO

Esta revisão tem o objetivo de entender melhor o funcionamento e os problemas enfrentados, em biotérios de criação e fornecedores de animais de laboratório e assim, sugerir um plano de ação com o intuito de desenvolver melhores práticas, buscando uma filosofia de gerenciamento que procura otimizar uma organização de forma a atender as necessidades do cliente no menor prazo possível, na mais alta qualidade e ao mais baixo custo, no que concerne a previsão de animais e a não utilização pelo pesquisador após o acasalamento, o que gera a utilização de todos os itens disponibilizados na linha de produção e Recursos Humanos e quanto maior a porcentagem desta perda, maior o prejuízo da empresa. Neste trabalho foram sugeridos critérios a serem adotados a fim otimizar a produção de animais de laboratório. (AU)

This study aims to better understand the functioning and problems encountered, generally in creating units and suppliers of laboratory animals and thus suggest a plan of action in order to suggest the best practices, seeking a philosophy of management that seeks to optimize an organization to meet customer needs in the shortest possible time, in the highest quality and the lowest cost, aligned to the ethical and animal welfare with respect to prediction of animals and not used by the researcher after mating, which leads to the use of all available items on the production line and Human Resources and the higher the percentage of this loss, the greater the loss of the company. In this work criteria to be met in order to optimize the production of laboratory animals have been suggested. (AU)

Assuntos

RESUMO

Esta revisão tem o objetivo de entender melhor o funcionamento e os problemas enfrentados, em biotérios de criação e fornecedores de animais de laboratório e assim, sugerir um plano de ação com o intuito de desenvolver melhores práticas, buscando uma filosofia de gerenciamento que procura otimizar uma organização de forma a atender as necessidades do cliente no menor prazo possível, na mais alta qualidade e ao mais baixo custo, no que concerne a previsão de animais e a não utilização pelo pesquisador após o acasalamento, o que gera a utilização de todos os itens disponibilizados na linha de produção e Recursos Humanos e quanto maior a porcentagem desta perda, maior o prejuízo da empresa. Neste trabalho foram sugeridos critérios a serem adotados a fim otimizar a produção de animais de laboratório.

This study aims to better understand the functioning and problems encountered, generally in creating units and suppliers of laboratory animals and thus suggest a plan of action in order to suggest the best practices, seeking a philosophy of management that seeks to optimize an organization to meet customer needs in the shortest possible time, in the highest quality and the lowest cost, aligned to the ethical and animal welfare with respect to prediction of animals and not used by the researcher after mating, which leads to the use of all available items on the production line and Human Resources and the higher the percentage of this loss, the greater the loss of the company. In this work criteria to be met in order to optimize the production of laboratory animals have been suggested.

Assuntos