RESUMO

BACKGROUND: Brazilian Oral Pathology (OP) and Oral Medicine (OM) have gained significant international recognition. However, no study has yet evaluated the impact of citations in scientific publications. Therefore, this study aimed to analyze the impact of citations from Brazilian researchers in OP and OM over the last two decades. MATERIAL AND METHODS: This was a cross-sectional study involving 50 researchers linked to postgraduate programs in OP/OM. Data collected from each professional's Lattes curriculum included gender, academic affiliation, the corporate category of the institution, and location. The number of papers published and citations received between 2004 to 2013 and 2014 to 2023 was also collected from the Web of Science database. RESULTS: Most researchers were male (56%) and from public institutions (90%), mainly in the Southeast region (60%). Over two decades, they collectively published 8,033 scientific articles, with significant growth (p<0.001) from to 2004-2013 to 2014-2023. While the average citations per researcher did not differ significantly between 2004-2013 and 2014-2023 (p=0.538), there was a notable 67.67% increase in citations in the last decade. CONCLUSIONS: Brazilian researchers in the areas of OP and OM have demonstrated a significant academic impact over the past two decades, with a marked increase in publications and citations over the last ten years. This highlights the contribution of Brazilians to the global scientific community in these areas.

Assuntos

Bibliometria , Medicina Bucal , Patologia Bucal , Brasil , Estudos Transversais , Patologia Bucal/estatística & dados numéricos , Humanos , Editoração/estatística & dados numéricos , Fatores de Tempo , Masculino , Feminino , Pesquisadores/estatística & dados numéricos

RESUMO

BACKGROUND: With the COVID-19 pandemic, there was a need to adopt online teaching methods in a generalized and sudden way, a situation that led to unprecedented changes in the routine of post-graduate students and research development. This study aimed to analyze the evaluation of remote teaching by graduates of master's degrees and advisors in master's programs in the Oral Pathology and Oral Medicine who needed to adapt to a remote teaching methodology in the pandemic. MATERIAL AND METHODS: This quantitative study evaluated the remote teaching in the perception of master's graduates and advisors from postgraduate programs in Oral Pathology and Oral Medicine. Data were collected through an online Google forms® questionnaire. RESULTS: Participated in the study 14 master graduates and 14 master's advisors. Master graduates evaluated that the professors had a good performance (p=0.001), that the duration of the classes was adequate (p=0.015), that the interaction with professors was satisfactory (p=0.007), that they had good interaction with the advisor (p=0.001), that they were satisfied with the remote guidance process (p=0.038) and that face-to-face practical activities were missed (p=0.002). Master's advisors reported satisfaction with remote teaching, good adaptation (p=0.018) and motivation for remote teaching (p=0.016), they evaluated that students were cooperative in activities (p=0.019) and that face-to-face practical activities were missed (p=0.002). CONCLUSIONS: Despite the difficulties, remote teaching proved to be an effective alternative to face-to-face teaching.

Assuntos

COVID-19 , Pandemias , Humanos , Brasil , Patologia Bucal , Inquéritos e Questionários

RESUMO

OBJECTIVE: The present case report aims to make a discussion concerning oral manifestations in a patient with a confirmed diagnosis of COVID-19. Female patient, 20 years old, nursing technician, showed severe sore throat and headache without presence of fever. She tested positive for COVID-19 RT-PCR test in 2 episodes. She also showed lesions in the median lower lip semimucosa and severe pruritus, with a clinical course of 14 days, in which we performed a clinical diagnosis of herpes simplex infection. We need to be precise in terms of clinical appearance and possible relation with the disease, as the clinicians have access to the patients.

Assuntos

Infecções por Coronavirus/diagnóstico , Herpes Simples/diagnóstico , Pneumonia Viral/diagnóstico , Betacoronavirus/genética , Betacoronavirus/isolamento & purificação , COVID-19 , Infecções por Coronavirus/complicações , Infecções por Coronavirus/virologia , Feminino , Herpes Simples/complicações , Humanos , Mucosa Bucal/patologia , Pandemias , Pneumonia Viral/complicações , Pneumonia Viral/virologia , Prurido/complicações , Prurido/patologia , RNA Viral/metabolismo , SARS-CoV-2 , Adulto Jovem

RESUMO

BACKGROUND AND OBJECTIVE: LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. MATERIAL AND METHODS: Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. RESULTS: Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. CONCLUSION: LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease.

Assuntos

Doenças Periodontais/tratamento farmacológico , Doenças Periodontais/patologia , Pirimidinas/antagonistas & inibidores , Serotonina/metabolismo , Perda do Osso Alveolar/diagnóstico por imagem , Perda do Osso Alveolar/tratamento farmacológico , Perda do Osso Alveolar/patologia , Perda do Osso Alveolar/prevenção & controle , Animais , Colágeno , Modelos Animais de Doenças , Gengiva/patologia , Ligadura/efeitos adversos , Masculino , Mandíbula/patologia , Perda da Inserção Periodontal/diagnóstico por imagem , Perda da Inserção Periodontal/prevenção & controle , Periodontite/tratamento farmacológico , Periodontite/patologia , Ratos , Ratos Wistar , Serotonina/fisiologia , Microtomografia por Raio-X/métodos

RESUMO

This study evaluated the antifungal activity of Persea americana extract on Candida albicans biofilm and its cytotoxicity in macrophage culture (RAW 264.7). To determine the minimum inhibitory concentration (MIC), microdilution in broth (CLSI M27-S4 protocol) was performed. Thereafter, the concentrations of 12.5, 25, 50, 100, and 200 mg/mL (n = 10) with 5 min exposure were analyzed on mature biofilm in microplate wells for 48 h. Saline was used as control (n = 10). After treatment, biofilm cells were scraped off and dilutions were plated on Sabouraud dextrose agar. After incubation (37°C/48 h), the values of colony forming units per milliliter (CFU/mL) were converted to log10 and analyzed (ANOVA and Tukey test, 5%). The cytotoxicity of the P. americana extract was evaluated on macrophages by MTT assay. The MIC of the extract was 6.25 mg/mL and with 12.5 mg/mL there was elimination of 100% of planktonic cultures. Regarding the biofilms, a significant reduction (P < 0.001) of the biofilm at concentrations of 50 (0.580 ± 0.209 log10), 100 (0.998 ± 0.508 log10), and 200 mg/mL (1.093 ± 0.462 log10) was observed. The concentrations of 200 and 100 mg/mL were cytotoxic for macrophages, while the concentrations of 50, 25, and 12.5 mg/mL showed viability higher than 55%.

Assuntos

Antifúngicos/farmacologia , Biofilmes/efeitos dos fármacos , Candida/efeitos dos fármacos , Persea/química , Extratos Vegetais/farmacologia , Animais , Antifúngicos/toxicidade , Candida/fisiologia , Linhagem Celular , Macrófagos/efeitos dos fármacos , Camundongos , Extratos Vegetais/toxicidade

RESUMO

OBJECTIVE: The purpose of this study was to investigate the use of saliva for the identification of human cytomegalovirus (HCMV) in allogeneic hematopoietic stem cell transplant patients by real time PCR compared with blood. MATERIALS AND METHODS: Saliva and blood samples were sampled weekly in 30 allogeneic hematopoietic stem cell transplant patients until 100 days after transplant. Total genomic DNA, extracted from saliva and whole-blood samples, was used for HCMV real time PCR. Nonparametric tests were performed, and P value

Assuntos

Citomegalovirus/isolamento & purificação , DNA Viral/análise , Transplante de Células-Tronco Hematopoéticas , Saliva/virologia , Adolescente , Adulto , Antígenos Virais/análise , Antígenos Virais/sangue , Antivirais/uso terapêutico , Criança , Citomegalovirus/genética , Citomegalovirus/imunologia , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/tratamento farmacológico , DNA Viral/sangue , Estudos de Viabilidade , Feminino , Seguimentos , Ganciclovir/uso terapêutico , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Fosfoproteínas/análise , Fosfoproteínas/sangue , Reação em Cadeia da Polimerase , Estudos Prospectivos , Transplante Homólogo , Carga Viral , Proteínas da Matriz Viral/análise , Proteínas da Matriz Viral/sangue , Viremia/virologia , Ativação Viral , Adulto Jovem

RESUMO

PURPOSE: To analyse the use of the exercise testing as the method of initial evaluation, following a prognostic indicative of patients with congenital complete heart block. METHODS: Five patients were analysed (3 men and 2 woman) with ages between 7 and 34 years (mean = 22.8). The patients were submitted to a treadmill exercise testing using the Bruce protocol 1 and symptom limited. RESULTS: In all patients the atrial frequency increased from a median of 74.40 bpm in the basal to 155.20 bpm in the maximum effort; the atrial chronotropism was a little below that calculated based on the age of the patients. The median of the ventricular frequency in the maximum effort was 94.80 bpm, very different from that foreseen and showing a deficit of ventricular chronotropism. The median consumption of oxygen was 35.68ml0(2)/Kg/min. In one patients (20%) there was not any change in the ventricular frequency with the effort, in 3 (60%) complex ventricular arrhythmia arise during the effort and in one (20%) a definitive ventricular pacemaker was implanted. CONCLUSIONS: The exercise testing is a simple method of initial evaluation, providing information as chronotropism, functional capacity and the presence of arrhythmias, that can be very useful in the evaluation of prognostic. The presence of complex ventricular arrhythmias during the exercise is indicative of a more regular follow-up.

Assuntos

Teste de Esforço , Bloqueio Cardíaco/congênito , Síndrome de Adams-Stokes/etiologia , Adulto , Criança , Feminino , Bloqueio Cardíaco/diagnóstico , Bloqueio Cardíaco/fisiopatologia , Frequência Cardíaca , Humanos , Masculino , Prognóstico

RESUMO

A 27 year-old female patient presented with atypical chest pain. 2-D echocardiogram and thorax computed tomography revealed intrapericardial tumor. The patient was operated on for removal of the tumor, which turned out to be two isolated lipomas. The patient had a rapid postoperative recuperation.

Assuntos

Neoplasias Cardíacas/patologia , Lipoma/patologia , Neoplasias Primárias Múltiplas , Adulto , Ecocardiografia , Feminino , Neoplasias Cardíacas/diagnóstico , Humanos , Lipoma/diagnóstico , Tomografia Computadorizada por Raios X

RESUMO

Os autores fizeram uma revisao da miocardite primaria na crianca e destacam que desde 1973 tiveram a oportunidade de observar 19 criancas portadoras desta patologia, sendo que somente sete foram incluidas nesta revisao, pois as demais tiveram o inicio da doenca, ou seja, sua fase aguda, em epoca anterior ao inicio deste trabalho. Comentam, tambem, os aspectos clinicos, radiologicos, eletrocardiograficos e terapeuticos e discutem as diferentes opinioes quanto ao uso, ou nao, da corticoterapia; dao enfase especial a evolucao e relatam que duas criancas evoluiram para a cura, quatro para uma forma cronica e uma para o obito. Todos os pacientes com evolucao cronica foram observados durante quatro anos e, progressivamente, no ECG, passaram a evidenciar sinais de acentuada hipertrofia ventricular esquerda com ondas Q importantes em V5 e V6. Frente a estes achados os autores comecaram os recentes trabalhos que indicam a possibilidade da fibroelastose endocardica ser determinada por uma previa miocardite a virus

Assuntos

Miocardite