RESUMO
OBJECTIVE: To identify the main research interests of Brazilian patients in the field of infertility and assisted reproductive technology (ART) treatments. METHODS: This prospective multicenter cross-sectional study was carried out in Brazil. Patients attending five fertility centers from the Huntington Group between October and December 2018 were invited to join the study, which consisted of answering an anonymous survey online. Two hundred and twenty-seven patients signed the informed consent form and were emailed the survey link. The survey was designed based on the James Lind Alliance Priority Setting Partnership protocol. In the area of infertility, patients were probed on issues such as somatic and psychological effects of treatment, prevention, assisted reproductive technology (medications and procedures), success rates, risks, and emotional aspects. RESULTS: The response rate (RR) was 47.58% (108 patients; 88 women - RR 51.46% and 20 men - RR 35.71%). Patient mean age was 36.5 years (SD 4.6). The top ten research priorities listed were 1) short- and long-term side effects of treatment; 2) how to cope with infertility; 3) risks associated with ART; 4) success rates in ART; 5) impact of diet on ART and fertility; 6) healthy habits; 7) alternative therapies; 8) impact of exercise on fertility and ART success; 9) oocyte quality and ovarian reserve; and 10) genetic or inherited causes of infertility. CONCLUSION: To better cater to the needs of patients and develop patient-centered care in the field of infertility and ART treatment, clinicians, healthcare providers, and the scientific community must identify patient concerns and priorities and make efforts to address them.
Assuntos
Pesquisa Biomédica , Infertilidade , Técnicas de Reprodução Assistida , Pesquisa , Adulto , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Estudos ProspectivosRESUMO
O Carcinoma Lobular Invasor (CLI) é uma patologia maligna e foi descrito em 1946 por Foote e Stewart. É o segundo tipo histológico de câncer de mama representando de 5?10% de todos os carcinomas. Caracteriza-se histopatologicamente como uma neoplasia epitelial lobular invasora com presença de células pequenas e uniformes. Trata-se de um relato de caso de uma paciente de 61 anos que, após 6 meses de acompanhamento, apresenta ao estudo mamográfico uma distor- ção arquitetural no Quadrante Superior Lateral (QSL) da mama direita (MD) em correspondência com alteração textural associada à sombra acústica posterior evidenciada à ultrassonografia (USG), nódulo espiculado e mal definido no QSL da mama esquerda (ME), BI-Rads 4c. Foi realizada uma punção por agulha fina (PAAF) na ME com laudo de agrupamento de células epiteliais atípicas e pequenas, sendo a hipótese de carcinoma a mais provável. A paciente foi submetida à segmentectomia bilateral e linfonodo sentinela da ME. O Laudo Histopatológico demonstrou CLI com linfonodo da ME livre de neoplasia. As características histopatológicas e clínicas do CLI fazem que os aspectos imaginológicos das lesões sejam de aparência variável. Portanto, a correlação entre as diferentes modalidades de imagem ajudam a determinar a extensão e o número de lesões.
Invasive Lobular Carcinoma (CLI) is a malignant disease and it was described in 1946 by Foote and Stewart. It is the second histological type of breast cancer representing 5?10% of all carcinomas. It is histopathologically characterized as an invasive lobular intraepithelial neoplasia, with the presence of small and uniform cells. We report the case of 61 year old that after 6 months of monitoring, her mammography study showed an architectural distortion in the Upper External (QSE) of right breast corresponding to textural changes associated with posterior acoustic shadow evident on ultrasonography (USG), spiculated and ill-defined nodule in the left breast QSE, BI -Rads 4c. A fine needle (FNA) puncture in the ME report with grouping of small and atypical epithelial cells with the carcinoma hypothesis most likely to be held. The patient underwent bilateral segmentectomy and sentinel lymph node of left breast. The Histopathology Report showed CLI lymph node of the left breast free of neoplasia. The histopathological and clinical characteristics of the CLI are the imaging features of the lesions are of variable appearance. Therefore, the correlation between the different imaging modalities help to determine the extent and number of injuries.