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Background: Lymphoma is a malignant lymphoid tumor originating in the lymph nodes or other solid organs and comprises90% of all hematopoietic tumors in dogs. However, primary kidney lymphoma is rare and is associated with nonspecificclinical signs. Tumor invasion in both kidneys can cause severe clinical signs due to renal failure, complicating the patientstreatment and prognosis. The aim of this case was to report the case of a dog affected by bilateral primary kidney lymphoma. In addition, to characterize the clinical and histopathological presentation due to the intense morphological changes.Case: A 5-year-old male Poodle dog was admitted showing apathy and emesis for 5 days. On physical examination, thedog showed 10% of dehydration, reddish oral mucous membranes, poor body condition (score 1/5), uremic breath, andpain in the kidney area. Complementary tests revealed severe low white blood cells count, high BUN levels, high levels ofpotassium, calcium, and phosphorus (serum biochemistry). Abdominal ultrasound showed bilateral kidney enlargement.Fine needle aspiration of the mass (guided by ultrasound) revealed round cell tumor. Radiographs showed no alterations.The dog died due to his poor condition and necropsy was performed. On post-mortem examination, the kidneys were bothenlarged, pale, and with an irregular subcapsular surface. The histopathological diagnostic was primary renal lymphoma.Immunohistochemical staining revealed that neoplastic cells were strongly positive for anti CD20 and PAX5, while negative for CD3, supporting the diagnosis of B-cell lymphoma.Discussion: The diagnosis was based on clinical, complementary tests, fine needle aspiration, histopathological andimmunohistochemical findings. In dogs, primary kidney tumors are uncommon and usually malignant. The presence ofvomiting, uremic breath, dehydration, weight loss, and erosive and ulcerative lesions on the tongue (uremic glossitis)...(AU)

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Background: Lymphoma is a malignant lymphoid tumor originating in the lymph nodes or other solid organs and comprises90% of all hematopoietic tumors in dogs. However, primary kidney lymphoma is rare and is associated with nonspecificclinical signs. Tumor invasion in both kidneys can cause severe clinical signs due to renal failure, complicating the patient’streatment and prognosis. The aim of this case was to report the case of a dog affected by bilateral primary kidney lymphoma. In addition, to characterize the clinical and histopathological presentation due to the intense morphological changes.Case: A 5-year-old male Poodle dog was admitted showing apathy and emesis for 5 days. On physical examination, thedog showed 10% of dehydration, reddish oral mucous membranes, poor body condition (score 1/5), uremic breath, andpain in the kidney area. Complementary tests revealed severe low white blood cells count, high BUN levels, high levels ofpotassium, calcium, and phosphorus (serum biochemistry). Abdominal ultrasound showed bilateral kidney enlargement.Fine needle aspiration of the mass (guided by ultrasound) revealed round cell tumor. Radiographs showed no alterations.The dog died due to his poor condition and necropsy was performed. On post-mortem examination, the kidneys were bothenlarged, pale, and with an irregular subcapsular surface. The histopathological diagnostic was primary renal lymphoma.Immunohistochemical staining revealed that neoplastic cells were strongly positive for anti CD20 and PAX5, while negative for CD3, supporting the diagnosis of B-cell lymphoma.Discussion: The diagnosis was based on clinical, complementary tests, fine needle aspiration, histopathological andimmunohistochemical findings. In dogs, primary kidney tumors are uncommon and usually malignant. The presence ofvomiting, uremic breath, dehydration, weight loss, and erosive and ulcerative lesions on the tongue (uremic glossitis)...

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Background: Congenital malformations are anomalies, structural or functional, that occur during the embryonic or fetal phase. There are several causes, one of which is the ingestion of toxic plants. Considering the importance of native toxic plants in the Central Backlands of Ceará state - Brazil, this paper reports cases of congenital malformations in sheep due to ingestion of Mimosa tenuiflora. Cases: Cases of abortion and malformations in sheep, were monitored in a rural property in the municipality of Piquet Carneiro with 20 ruminants (15 sheep and 5 cows) raised on a semi-intensive regime. The animals grazed during the day and were supplemented with corn, having unrestricted access to dam water. On its margins, there was a large amount of jurema preta (Mimosa tenuiflora), which the owner reported that the sheep consumed daily. The owner was unaware of the toxicity of M. tenuiflora but reported that cases of malformations had already occurred on his property some time ago. In an interval of approximately 12 days, 3 sheep miscarriage fetuses with multiple malformations. Malformed fetuses were referred for anatomopathological examination at the Animal Pathology Laboratory of the Veterinary Hospital of Federal University of Campina Grande (UFCG), Campus Patos, Paraíba, Brazil. The fetuses were necropsied and tissue samples of the nervous system and organs from the thoracic and abdominal cavities were collected, fixed in 10% neutral buffered formalin, routinely processed for histopathology, included in paraffin, cut into 3 µm sections and stained with hematoxylin and eosin (HE). At necropsies were observed permanent contracture of the thoracic limb joints (arthrogryposis), particularly at the radio-carpal joints; incomplete medial fusion of the palatal bone, with communication between the oral and nasal cavities (palatoschisis); hypoplasia of the mandibular bone (micrognathia); unilateral hypoplasia of the incisive bone with discontinuity of the upper lip (cheiloschisis); unilateral hypoplasia of the eyeball (microphthalmia); lateral curvature of the cervical spine (scoliosis); and chest deformity characterized by ventral protrusion of the sternum and ribs (Pectus carinatum). At the histopathological evaluation of the tissues, no alterations were observed. Discussion: The diagnosis was based on the epidemiological, clinical, and anatomopathological findings. The semi-intensive management system applied on the property predisposed the sheep to ingestion of M. tenuiflora, which grows abundantly on the property and throughout the Central Backlands of Ceará, Brazil, with a high rate of geographical coverage. Despite that, most rural producers, especially subsistence farmers, are unaware of the toxic and teratogenic properties of the plant. In the northeastern, where there are long periods of drought coupled with forage shortages, poisoning by M. tenuiflora is a common cause of malformation and mortality in lambs. Therefore, it is necessary to adopt preventive measures in herds, such as raising awareness among producers about the toxic potential of some native plants and the practice of producing and supplying silage to animals, so that native toxic plants are not the only food source during the scarcity period.

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O adenocarcinoma de glândula apócrina raramente é relatado em cães, acometendo principalmente animais idosos e não tendo propensão entre machos ou fêmeas. Habitualmente, apresentam-se por nódulos únicos, podendo chegar até 10cm de diâmetro e, nos cães, os membros torácicos e pélvicos são os sítios de predileção. Geralmente, as neoplasias de glândulas apócrinas têm comportamento benigno, quando estas apresentam potencial maligno observam-se recidivas através de disseminação linfática e sanguínea. Relatou-se o caso de um cão macho, da raça Poodle, de 16 anos de idade, não castrado. A queixa principal referiu-se a uma lesão em orelha direita que apresentava secreção sanguinopurulenta há 30 dias, porém, ao exame físico, foi observado pequena massa no membro torácico direito, juntamente com linfonodo subescapular direito reativo. Foi colhido material de ambos os locais para exame citológico, o qual teve um resultado inconclusivo. Foi realizada nodulectomia em membro torácico direito, linfadenectomia subescapular e nodulectomia auricular. O material foi enviado para análise histopatológica. O diagnóstico foi de adenocarcinoma de glândula apócrina em membro torácico com metástase para linfonodo pré-escapular e de epitelioma sebáceo na lesão auricular. A tutora não aderiu ao protocolo quimioterápico proposto e o paciente veio a óbito após 30 dias do procedimento cirúrgico.

The apocrine gland adenocarcinoma is rarely reported in dogs, common in dogs and having no sex predisposition. They usually present a single lump reaching up 10 cm in diameter. In dogs, the thoracic and pelvic limbs are the common sites. Generally, the apocrine gland neoplasms have a benign behavior; metastasis can occur through lymphatic and blood dissemination when they are malignant. We report the case of a 16-year-old, uncastrated, male Poodle dog. The client reported a lesion in the right ear that had purulent and bloody discharge for 30 days, however, on physical examination, a small mass was observed in the right thoracic limb together with a reactive right subscapular lymph node. Samples were collected from both sites for cytological examination, which had an inconclusive result. Nodulectomy was performed on the right thoracic limb, subscapular lyphadenectomy and auricular nodulectomy. The histopathological analysis revealed an apocrine gland adenocarcinoma in the thoracic limb with metastasis to the cervical lymph node and sebaceous epithelioma in the auricular lesion. The client refused the chemotherapy protocol proposed and, the patient died 30 days after the surgical procedure.

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