RESUMO
Two dihydroflavonol rhamnosides (1 and 2) isolated from the bark of Hymenaea parvifolia and two pentacyclic triterpenoids (3 and 6) obtained from the leaves of Wulffia baccata have been found to exhibit inhibitory effects of casein kinase II (CK-II) dose-dependently, suggesting that at higher doses more than 10 microM, these four compounds may act as potent CK-II suppressors of the CK-II-mediated activation of 60S acidic ribosomal P proteins in vitro.
Assuntos
Inibidores Enzimáticos/farmacologia , Flavonoides/farmacologia , Proteínas Serina-Treonina Quinases/antagonistas & inibidores , Rosales/química , Triterpenos/farmacologia , Brasil , Caseína Quinase II , Inibidores Enzimáticos/isolamento & purificação , Flavonoides/isolamento & purificação , Flavonóis , Fosforilação/efeitos dos fármacos , Folhas de Planta/química , Proteínas Ribossômicas/metabolismo , Triterpenos/isolamento & purificaçãoRESUMO
From Jatropha cilliata M. Arg., a Peruvian medicinal plant, isoorientin and orientin were isolated as anxiolytic components by using the isolation guide of anti-conflict effect in mice. Several related flavonoids were also tested for this effect. Another bioassay-guided isolation using the acetic acid-induced writhing method gave a coumarin compound, fraxetin, as an analgesic principle.
Assuntos
Ansiolíticos/isolamento & purificação , Plantas Medicinais/química , Analgésicos/síntese química , Analgésicos/farmacologia , Analgésicos não Narcóticos/farmacologia , Animais , Ansiolíticos/química , Ansiolíticos/farmacologia , Comportamento Animal/efeitos dos fármacos , Temperatura Corporal/efeitos dos fármacos , Conflito Psicológico , Diazepam/farmacologia , Relação Dose-Resposta a Droga , Eletrochoque , Masculino , Espectrometria de Massas , Camundongos , Camundongos Endogâmicos , Peru , RatosRESUMO
"Paico," Chenopodium ambrosioides L., is a traditional Peruvian medicine which is considered to be nervine, antirheumatic, anthelmintic, etc. An attempt was made to isolate the component having sedative and/or analgesic properties from "Paico" and "Aritasou" (the Japanese name for C. ambrosioides). Ascaridole was identified as the active principle in both materials.