RESUMO
Although multiple studies have shown the role genetics plays in personality disorders and in addictions, few have studied the genetic aspects of their comorbidity. Here, we carried out a cross-sectional study in a sample comprising 303 Caucasian polydrug-consuming patients. The presence of personality disorders was evaluated using the International Personality Disorder Examination, and genes related to dopamine, serotonin and monoamine oxidase (MAO) were genotyped. A significant relationship was observed between the bp 279 DRD5 variable number of tandem repeat (VNTR) polymorphism and paranoid personality disorder OR 95 % CI = 2.186 1.074 ; 4.449 ; p = 0.006 . The bp 182 OR 95 % CI = 0.407 0.178 ; 0.931 ; p = 0.033 and bp 184 OR 95 % CI = 0.391 0.188 ; 0.813 ; p = 0.012 alleles of the MAOB VNTR were also associated with antisocial personality disorder. Among patients with addictions, paranoid personality disorder should also be considered in addition to the importance of antisocial and borderline personality disorders. The higher frequency of the bp 279 DRD5 VNTR allele found in patients with paranoid personality disorder, as well as the associations between alleles of the MAOB VNTR and antisocial personality disorder, support the monoaminergic bases of these personality disorders, especially when dealing with patients with addictions.
Assuntos
Transtorno da Personalidade Antissocial , Polimorfismo Genético , Humanos , Transtorno da Personalidade Antissocial/genética , Monoaminoxidase/genética , Repetições Minissatélites , Estudos Transversais , Receptores de Dopamina D5/genéticaRESUMO
Introducción: el cáncer cervicouterino persiste como un problema de salud no resuelto a nivel mundial; después del cáncer de mama, es el más frecuente en el sexo femenino y ocupa el séptimo lugar entre todas las neoplasias malignas que afectan a ambos sexos. Objetivo: describir el comportamiento de la mortalidad por cáncer cervicouterino en el municipio de Rafael Freyre entre 1997 y 2014. Método: se realizó un estudio de mortalidad con las 56 fallecidas reportadas por esa causa en el municipio y períodos referidos. Como fuente de datos se utilizó el reporte mensual computarizado que envía el Departamento de Estadísticas provincial de los fallecidos a cada municipio. Resultados: la tasa media anual de mortalidad en el municipio fue de 12,3 x 100 000 mujeres; los grupos de edades más afectados son los de 70-74 y 80 y más, con tasas de 62,5 y 60,0, respectivamente. Las áreas geográficas de mayor riesgo epidemiológico de fallecer las mujeres por esta causa fueron el Área de Salud de Santa Lucía y los consejos populares de "Carlos Noris", Dagame y Santa Lucía, con tasas de mortalidad de 23,5; 21,5 y 19,5, respectivamente. Conclusiones: este problema de salud tiene una tendencia descendente en el municipio, pero la tasa de mortalidad media anual supera la tasa provincial y la nacional.
Introduction: cervical cancer persists as an unresolved health problem worldwide; after breast cancer, it is the most frequent in females and ranks seventh among all malignant neoplasms affecting both sexes. Objective: to describe the behavior of cervical cancer mortality in the municipality of Rafael Freyre among the years 1997-2014. Methods: a mortality study was carried out, as universe was chosen the 56 deceaseds reported by that cause in the municipality at referred periods, as a source of data was used the monthly report of death on-line that sends the provincial department of health in Holguin. Results: the annual half rate of mortality in the Municipality was 12.3 x 100 000 women, the groups of ages more affected were 70-74 years and 80 and but, with rates of 62.5 and 60.0 respectively. The geographical areas of more epidemic risk of dying the women for this cause were, the Area of Health of "Santa Lucía" and popular Council of "Carlos Noris", "Dagame" and "Santa Lucía" with rates of mortality of 23.5, 21.5 and 19.5 respectively. Conclusions: this problem of health has a descending tendency in the municipality, but the rate half annual of mortality overcomes the provincial and national rate.
RESUMO
PURPOSE: It has long been debated whether human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) are associated with rectal cancer. The gene products of HCMV and EBV contribute to cell-cycle progression, mutagenesis, angiogenesis and immune evasion. The aim of this prospective study was to analyse the association between infection of a tumour by HCMV and EBV and clinical, histological, metabolic ((18)F-FDG uptake), volumetric (from CT) and molecular (KRAS status) features and long-term outcomes in a homogeneously treated group of patients with locally advanced rectal cancer. METHODS: HCMV and EBV were detected in pretreatment biopsies using polymerase chain reaction (PCR). The Cox proportional hazards regression model was used to explore associations between viral infection and disease-free survival (DFS) and overall survival (OS). RESULTS: We analysed 37 patients with a median follow-up of 74 months (range 5-173 months). Locoregional control, OS and DFS at 5 years were 93%, 74% and 71%, respectively. Patients with HCMV/EBV coinfection had a significantly higher maximum standardized uptake value than patients without viral coinfection (p = 0.02). Significant differences were also observed in staging and percentage relative reduction in tumour volume between patients with and without HCMV infection (p < 0.01) and EBV infection (p < 0.01). KRAS wildtype status was significantly more frequently observed in patients with EBV infection (p <0.01) and HCMV/EBV co-infection (p = 0.04). No significant differences were observed in OS or DFS between patients with and without EBV infection (p = 0.88 and 0.73), HCMV infection (p = 0.84 and 0.79), and EBV/CMV coinfection (p = 0.24 and 0.39). CONCLUSION: This pilot study showed that viral infections were associated with metabolic staging differences, and differences in the evolution of metabolic and volumetric parameters and KRAS mutations. Further findings of specific features will help determine the best candidates for metabolic and volumetric staging and restaging. Further toxicity profile findings will help to determine the best candidates for specific supportive treatment during pelvic chemoradiotherapy in patients with locally advanced rectal cancer.
Assuntos
Infecções por Citomegalovirus/diagnóstico por imagem , Infecções por Vírus Epstein-Barr/diagnóstico por imagem , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Neoplasias Retais/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto , Idoso , Quimiorradioterapia , Infecções por Citomegalovirus/complicações , Infecções por Vírus Epstein-Barr/complicações , Feminino , Fluordesoxiglucose F18/farmacocinética , Humanos , Masculino , Pessoa de Meia-Idade , Imagem Multimodal , Terapia Neoadjuvante , Proteínas Proto-Oncogênicas/genética , Proteínas Proto-Oncogênicas p21(ras) , Compostos Radiofarmacêuticos/farmacocinética , Neoplasias Retais/complicações , Neoplasias Retais/genética , Neoplasias Retais/terapia , Proteínas ras/genéticaAssuntos
Cães , Ratos , Animais , Raiva/epidemiologia , Estudos de Coortes , Equador , Vírus da RaivaRESUMO
Bioquímica estructural. Lípidos. Proteínas. Acidos nucleicos. Enzimas. Enzimas digestivas. Introducción al metabolismo. Metabolismo de los hidratos de carbono, del glucógeno, disacáridos y de los ácidos urónicos. Ciclo de los ácidos tricarboxílicos, del ácido cítrico o de Krebs. Fosforilación oxidativa. Metabolismo de los lípidos, del colesterol, de los aminoácidos, y del grupo hemo. Reacciones de desintoxicación. Duplicación y reparación del ácido desoxirribonucleico. Síntesis de proteínas. Regulación metabólica. Plasma y proteínas plasmáticas. Antígenos, anticuerpos e interacciones entre ambos: modo de detectarlas. Hemoglobina y mioglobina. Aspectos bioquímicos de la función muscular. Bioquímica del sistema nervioso, del tejido conectivo y de la piel. Las vitaminas. Bioquímica de las excreciones. Fotosíntesis
Assuntos
Humanos , Bioquímica/educação , Fenômenos Bioquímicos , Metabolismo , Metabolismo/fisiologiaRESUMO
Bioquímica estructural. Lípidos. Proteínas. Acidos nucleicos. Enzimas. Enzimas digestivas. Introducción al metabolismo. Metabolismo de los hidratos de carbono, del glucógeno, disacáridos y de los ácidos urónicos. Ciclo de los ácidos tricarboxílicos, del ácido cítrico o de Krebs. Fosforilación oxidativa. Metabolismo de los lípidos, del colesterol, de los aminoácidos, y del grupo hemo. Reacciones de desintoxicación. Duplicación y reparación del ácido desoxirribonucleico. Síntesis de proteínas. Regulación metabólica. Plasma y proteínas plasmáticas. Antígenos, anticuerpos e interacciones entre ambos: modo de detectarlas. Hemoglobina y mioglobina. Aspectos bioquímicos de la función muscular. Bioquímica del sistema nervioso, del tejido conectivo y de la piel. Las vitaminas. Bioquímica de las excreciones. Fotosíntesis