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Biomed Res Int ; 2017: 5746768, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28197414

RESUMO

Sclerosing agents as zinc gluconate-based chemical sterilants (Infertile®) are used for chemical castration. This solution is injected into the animal testis, but there are not enough evidences of its safety profiles for the receivers. The present work aimed to establish the pharmacokinetics and toxicological activity of Infertile, using in vitro and in silico approaches. The evaluation at the endpoint showed effects in a dose-dependent manner. Since necrosis is potentially carcinogenic, the possible cell death mechanism could be apoptosis. Our data suggested that Infertile at 60 mM presented risk for animal health. Even though Infertile is a licensed product by the Brazilian Ministry of Agriculture, Livestock and Supply, it presented a high mutagenic potential. We suggest that the optimal dose must be less than 6 mM, once, at this concentration, no mutagenicity or genotoxicity was observed.


Assuntos
Carcinógenos/toxicidade , Gluconatos/farmacologia , Gluconatos/toxicidade , Testículo/efeitos dos fármacos , Animais , Apoptose/efeitos dos fármacos , Brasil , Castração/métodos , Simulação por Computador , Gluconatos/química , Gluconatos/farmacocinética , Masculino , Camundongos , Testes de Mutagenicidade , Células RAW 264.7 , Salmonella enterica/química , Salmonella enterica/efeitos dos fármacos , Testículo/patologia
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