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The fabrication of customized implants by additive manufacturing has allowed continued development of the personalized medicine field. Herein, a 3D-printed bioabsorbable poly (lactic acid) (PLA)- ß-tricalcium phosphate (TCP) (10 wt %) composite has been modified with CeO2 nanoparticles (CeNPs) (1, 5 and 10 wt %) for bone repair. The filaments were prepared by melt extrusion and used to print porous scaffolds. The nanocomposite scaffolds possessed precise structure with fine print resolution, a homogenous distribution of TCP and CeNP components, and mechanical properties appropriate for bone tissue engineering applications. Cell proliferation assays using osteoblast cultures confirmed the cytocompatibility of the composites. In addition, the presence of CeNPs enhanced the proliferation and differentiation of mesenchymal stem cells; thereby, increasing alkaline phosphatase (ALP) activity, calcium deposition and bone-related gene expression. Results from this study have shown that the 3D printed PLA-TCP-10%CeO2 composite scaffold could be used as an alternative polymeric implant for bone tissue engineering applications: avoiding additional/revision surgeries and accelerating the regenerative process.

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ABSTRACT: Nunes, ACCA, Cattuzzo, MT, Faigenbaum, AD, and Mortatti, AL. Effects of integrative neuromuscular training and detraining on countermovement jump performance in youth volleyball players. J Strength Cond Res 35(8): 2242-2247, 2021-The purpose of this study was to analyze the effect of integrative neuromuscular training (INT) on countermovement vertical jump height (CVJH) performance in youth volleyball players before and after a detraining period. Thirty-two novice volleyball players were cluster randomized into 2 groups: intervention group-INT (age: 13.1 ± 0.4 years; body mass: 55.3 ± 12.1 kg; and height: 161.1 ± 6.4 cm) and control group-CON (age: 12.8 ± 0.7 years; body mass: 51.8 ± 13.6 kg; and height: 160.1 ± 10.7 cm). The subjects were evaluated for somatic maturation (years from peak height velocity) and for CVJH performance at 4 time points during the 20-week study period: baseline, 6 weeks of INT, 12 weeks of INT, and 8 weeks after INT (detraining). The analysis used repeated-measures analysis of variance and Bonferroni post hoc test to identify possible differences in the CVJH delta in both groups. Spearman correlation was performed to verify the association between the values of the vertical jump tests and maturational levels found. The INT showed a significant improvement in the CVJH from baseline to 12 weeks and maintained training-induced gains after detraining period (p > 0.001). Significant increase in CVJH was found in the percentage of change (Δ%) from baseline to 6 weeks (p < 0.005), 12 weeks (p < 0.001), and detraining (p < 0.001) in INT compared with the CON. The results of this study indicate that INT was able to improve CVJH performance in novice youth volleyball players and these gains were sustained during the detraining period. These findings indicate that regular participation in supervised INT can enhance jumping performance in young volleyball players, and that this type of neuromuscular program may be particularly beneficial for youth with limited fundamental motor skill performance.

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Objetivos: Estudar a influência dos antecedentes familiares sobre o nível pressórico arterial basal na infância, bem como estabelecer aquele antecedente que, quando presente, traria consigo uma maior suscetibilidade à hipertensäo essencial. Materiais e métodos: Foram 1.580 crianças entre 2 e 13 anos submetidas a mensuraçäo antropométrica, estimativas pressóricas e tiveram seus antecedentes para hipertensäo arterial essencial pesquisado com os dados anotados em protocolo individualizado. Após, as mesmas foram subdivididas conforme substrato racial e sexo e agrupadas em funçäo da altura em centímetros. Posteriormente, foram reagrupadas em quatro subgrupos, de acordo com os antecedentes para hipertensäo arterial: crianças sem antecedente para hipertensäo essencial, com antecedentes de avós hipertensos, com antecedentes de pais hipertensos e com mais de um antecedente positivo para hipertensäo. Os valores pressóricos das subpopulaçöes correspondentes foram entäo comparados entre si e com a populaçäo global com auxílio do teste t de Student. Resultados: A populaçäo global apresentou valores de pressöes arteriais médias significativamente maiores que a populaçäo sem antecedentes em quase todos os intervalos de altura e para todas as raças (0,1

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