RESUMO
BACKGROUND: There is growing evidence that gut flora plays a role in the development of Irritable Bowel Syndrome (IBS). Abdominal bloating is a common symptom in these patients and the severity of this symptom could be related to the variations in their fermentative profiles, obtained by measuring the levels of breath hydrogen excretion after lactulose ingestion. AIMS: Our objective was to determine the difference in abdominal bloating severity between IBS patients with high vs low levels of breath hydrogen excretion after lactulose administration. METHODS: Lactulose breath tests were carried out on IBS patients in our institution between July 2009 and August 2010. Patients were requested to fill out a validated questionnaire to assess the severity of their symptoms. Abdominal bloating severity score was compared among patients with high and low breath hydrogen levels. RESULTS: A total of 234 patients were enrolled. There was a statistically significant difference in the abdominal bloating severity score between groups: 7.0 (5.7-8.0) vs 6.5 (5.0-7.5), p=0.001. The comparison among IBS patients with constipation (IBS-C) in both groups also showed a statistically significant difference: 7.5 (6.0-8.5) vs 5.8 (3.5-7.2), p=0.0051. CONCLUSIONS: Those patients with a low level of breath hydrogen excretion after lactulose ingestion presented with significantly greater abdominal bloating than those with a high level of breath hydrogen excretion.
Assuntos
Testes Respiratórios/métodos , Fármacos Gastrointestinais , Hidrogênio/metabolismo , Síndrome do Intestino Irritável/diagnóstico , Síndrome do Intestino Irritável/metabolismo , Lactulose , Abdome/patologia , Adulto , Idoso , Área Sob a Curva , Constipação Intestinal/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Adulto JovemRESUMO
Forty-nine patients with a diagnosis of idiopathic haemolytic uraemic syndrome (HUS) were investigated to determine evidence of infection by verotoxin-producing Escherichia coli (VTEC). Free faecal cytotoxin active on Vero cells (VT) was detected in 15 out of 49 patients (31%). Seroconversion or high titres of VT-neutralizing antibodies were detected in 11 out of 18 patients (61%). The results of the present study suggest an association between HUS and infection by VTEC.
Assuntos
Anticorpos Antibacterianos , Toxinas Bacterianas/imunologia , Síndrome Hemolítico-Urêmica/imunologia , Pré-Escolar , Citotoxinas/imunologia , Escherichia coli/imunologia , Infecções por Escherichia coli/complicações , Infecções por Escherichia coli/imunologia , Fezes/microbiologia , Feminino , Síndrome Hemolítico-Urêmica/complicações , Humanos , Lactente , Masculino , Testes de Neutralização , Toxina Shiga IRESUMO
Rubella virus antibodies were measured in 85 sera from pregnant women by using a new latex test, and the results were compared with those obtained by using hemagglutination inhibition. The sensitivity of the latex test was 98.4%, specificity was 66.6% and the predictive value of a positive result was 90%. The latex test is a simple test and has much shorter reaction time than that of the hemagglutination inhibition.
Assuntos
Anticorpos Antivirais/análise , Testes de Inibição da Hemaglutinação , Testes de Fixação do Látex , Complicações Infecciosas na Gravidez/diagnóstico , Vírus da Rubéola/imunologia , Rubéola (Sarampo Alemão)/diagnóstico , Feminino , Humanos , Valor Preditivo dos Testes , GravidezRESUMO
Rubella virus antibodies were measured in 85 sera from pregnant women by using a new latex test, and the results were compared with those obtained by using hemagglutination inhibition. The sensitivity of the latex test was 98.4
, specificity was 66.6
and the predictive value of a positive result was 90
. The latex test is a simple test and has much shorter reaction time than that of the hemagglutination inhibition.