RESUMO
Chronic mucocutaneous candidiasis is a heterogenous group of disorders, associated with a variety of autoimmune disorders and a broad spectrum of immune aberrations. We describe 2 patients with chronic mucocutaneous candidiasis who had cerebrovascular disease with severe neurologic sequelae. Results of angiography of cerebral vessels and brain biopsy in one were consistent with the diagnosis of cerebral vasculitis.
Assuntos
Candida albicans/isolamento & purificação , Candidíase Mucocutânea Crônica/complicações , Candidíase Mucocutânea Crônica/microbiologia , Córtex Cerebral/microbiologia , Hematoma/microbiologia , Vasculite/etiologia , Adulto , Antígenos de Bactérias/imunologia , Antígenos CD/imunologia , Angiografia Cerebral/métodos , Córtex Cerebral/diagnóstico por imagem , Córtex Cerebral/patologia , Hematoma/diagnóstico por imagem , Hematoma/patologia , Humanos , Imunoglobulinas/sangue , Imunoglobulinas/imunologia , Masculino , Tomografia Computadorizada por Raios XRESUMO
A 10-year prospective cohort study followed the evolution of antibodies in children less than 4 years of age with hypogammaglobulinemia. Three patterns were identified: in group 1, immunoglobulins and antibody production normalized;iin group 2, patients continued to have low IgG levels; and in group 3, IgG levels normalized but antibody levels were transient. Statistical analysis showed that invasive infection or low tetanus antibodies at presentation were associated with the development of significant humoral immunodeficiency.