1.
J Pediatr
; 150(1): 109-111.e2, 2007 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17188629
RESUMO
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.