RESUMO

Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. This case in addition to the accompanied review of literature illustrates the importance of the awareness of central nervous system involvement by MF and highlights the need for an urgent neurologic evaluation in patients with a history of MF now presenting with neurologic signs or symptoms.

Assuntos

Neoplasias Encefálicas/patologia , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/genética , Neoplasias do Sistema Nervoso Central/diagnóstico , Raios gama/uso terapêutico , Plasmócitos/patologia , Linfoma Plasmablástico/diagnóstico , Adulto , Neoplasias do Sistema Nervoso Central/patologia , Neoplasias do Sistema Nervoso Central/terapia , Lobo Frontal/efeitos dos fármacos , Lobo Frontal/patologia , Lobo Frontal/efeitos da radiação , Expressão Gênica , HIV , Herpesvirus Humano 4 , Humanos , Masculino , Linfoma Plasmablástico/patologia , Linfoma Plasmablástico/terapia , Proteínas Proto-Oncogênicas c-myc/genética , Proteína Supressora de Tumor p53/genética