RESUMO

We describe 16 HIV-infected patients with disseminated histoplasmosis (14 men, mean age 28 +/- 7.84 years), diagnosed at Hospital Eva Perón in Argentina during the period of October 1993 to July 2000. Disseminated histoplasmosis occurred in 5.3% of HIV-infected patients over the study period. The main symptoms included fever, weight loss and hepatosplenomegaly in 93.8%. Other relevant findings were respiratory compromise (56.3%), digestive symptoms (43.8%), mucocutaneous lesions (75%) and multiple lymphadenopathy (69%). Treatment consisted of amphotericin B 1 mg/kg/day up to a total dose of 1 g, followed by 400 mg/day of oral itraconazole. Mortality in the acute phase was 19% and 37.5% of patients relapsed.

Assuntos

Infecções Oportunistas Relacionadas com a AIDS/epidemiologia , Histoplasmose/epidemiologia , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Adolescente , Adulto , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Argentina/epidemiologia , Feminino , Febre/etiologia , Fluconazol/uso terapêutico , Hepatomegalia/etiologia , Histoplasmose/diagnóstico , Histoplasmose/tratamento farmacológico , Humanos , Itraconazol/uso terapêutico , Masculino , Recidiva , Transtornos Respiratórios/etiologia , Esplenomegalia/etiologia , Redução de Peso