RESUMO

Since the discovery of isoniacid in 1952, it has become apparent that there are considerable variations in the manner in which individuals react to the drug. We studied 90 patients from La Paz (3.600 m. over sea level) and 50 patients from Santa Cruz (470 m. over sea level). Our results in the two groups tested suggest that the high altitude hypoxia increases the velocity of inactivation. Despite to the influence of hypoxia it was seen that both groups have the some frequency of rapid and slow inactivators.

Assuntos

Altitude , Arilamina N-Acetiltransferase/metabolismo , Hipóxia/enzimologia , Isoniazida/farmacocinética , Acetilação , Adolescente , Adulto , Idoso , Antituberculosos/farmacocinética , Antituberculosos/uso terapêutico , Arilamina N-Acetiltransferase/genética , Biotransformação/genética , Bolívia/epidemiologia , Criança , Quimioterapia Combinada/uso terapêutico , Feminino , Humanos , Isoniazida/uso terapêutico , Cinética , Fígado/enzimologia , Masculino , Pessoa de Meia-Idade , Fenótipo , Polimorfismo Genético , Estreptomicina/uso terapêutico , Tioacetazona/uso terapêutico , Tuberculose/tratamento farmacológico , Tuberculose/enzimologia , Tuberculose/epidemiologia