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A hiperplasia endotelial intravascular ou tumor de Masson é uma lesão vascular benigna que não possui patogênese bem definida. Acredita-se que a resposta à lesão dos vasos sanguíneos seja um dos principais motivos para o seu desenvolvimento. É uma lesão tipicamente indolor, única e de evolução lenta. O objetivo deste relato é descrever um caso de tumor de Masson em uma região não habitual, na matriz ungueal do hálux, e discutir suas principais características

Intravascular endothelial hyperplasia, or Masson's tumor, is a benign vascular lesion with no well-defined pathogenesis. The response to vascular damage is believed to be one of the main reasons for its development. It is a typically painless injury, solitary, with slow evolution. This report aims to describe a case of Masson's tumor in an unusual place, the hallux nail matrix, and discuss its main characteristics.

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Introdução: A alopecia frontal fibrosante (AFF) é uma forma de alopecia cicatricial, em que os pacientes apresentam perda irreversível dos folículos pilosos, principalmente em região frontal e tempoparietal. Sua etiopatogenia não está totalmente elucidada, embora hipóteses sobre fatores genéticos, hormonais e comportamentais, como o uso de filtro solar e hidratante facial, já tenham sido descritas. Métodos: estudo de caso-controle, realizado com aplicação de um questionário objetivo com 33 perguntas. Foram avaliadas 60 pacientes do sexo feminino, 30 diagnosticadas com AFF e 30 não acometidas pela doença. Resultados: a média de idade da amostra foi de 64 anos (± 10,37 para casos e ± 9,40 para os controles). 76,7% das pacientes com AFF e 23,3% dos controles faziam uso de filtro solar, sendo a diferença estatisticamente significativa (p<0,001). Além disso, o uso de hidratante facial mostrou-se significativamente maior nas pacientes com alopecia (63,3%) quando comparadas aos controles (33,3%; p=0,038). Notou-se a frequência de uso de sabonete comum na face significativamente menor nas pacientes com AFF (46,7%), quando comparada ao grupo controle (83,3%; p=0,006). Conclusão: nossos resultados sugerem uma possível associação entre AFF e uso de produtos faciais, como filtro solar e hidratante. Todas as pacientes eram menopausadas, reforçando a relação hormonal com a doença

Introduction: Fibrosing Frontal Alopecia (FFA) is a form of scarring alopecia, in which patients have an irreversible loss of hair follicles, especially in the frontal and temporoparietal regions. The etiopathogenesis is not fully understood, although hypotheses about genetic, hormonal, and behavioral factors, such as the use of sunscreen and facial moisturizers, have already been described. Methods: A case-control study was conducted using an objective questionnaire with 33 questions. Sixty women were evaluated, 30 diagnosed with FFA, and 30 not affected by the disease. Results: The mean age of the sample was 64 years old. 76.7% of patients with FFA and 23.3% of controls used facial sunscreen and the difference was statistically significant (p<0.001). Also, the use of facial moisturizer was significantly higher in patients with alopecia (63.3%) when compared to controls (33.3%; p=0.038). The frequency of use of regular soap on the face was significantly lower in patients with FFA (46.7%) when compared to the control group (83.3%; p=0.006). Conclusion: Results suggest a possible association between FFA and the use of facial products, such as sunscreen and moisturizer, in this population. All patients were menopausal, reinforcing the hormonal relationship with the disease.

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BACKGROUND: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women. OBJECTIVES: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA). MATERIALS AND METHODS: NAFL and MN were used to treat striae on the longitudinally divided abdominal surface of 20 women classified as Fitzpatrick skin type III or IV (five sessions at monthly intervals). Photographs and skin biopsies were obtained during pretreatment and after the third and fifth treatment sessions for all patients. Patients and two independent evaluators assessed the clinical response using the Global Aesthetic Improvement Scale. RESULTS: Patient-reported evaluation showed improvement of striae using both modalities, with no statistically significant difference between the groups. Collagen and elastic fibers were significantly increased (p < 0.01) after the third and fifth treatment sessions, with no significant difference between the modalities. In addition, Dermatology Life Quality Index scores showed significant improvement (p < 0.001) after the third and fifth treatment sessions compared with pretreatment values, with average values of 8.4 (standard error [SE] ± 1.21), 3.17 (SE ± 0.55), and 2.64 (SE ± 0.60), respectively. The mean pain score using the Visual Analog Scale in the MN group versus the NAFL group was 5.23 (SE ± 0.31) versus 2.39 (SE ± 0.22) [p < 0.001], and the mean duration of adverse events in the NAFL group versus the MN group was 4.03 days (SE ± 0.45) versus 3 days (SE ± 0.37) [p = 0.02]. CONCLUSION: NAFL and MN are safe for treating SD, particularly in individuals classified as phototype III or IV. MN is a useful non-technology-dependent, low-cost alternative therapy for SA. CLINICAL TRIAL REGISTRATION NUMBER: NCT03390439.

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O sarcoma congênito da família Ewing é uma doença extremamente rara, que se manifesta através do surgimento de uma massa e sinais sistêmicos como dor e febre. Cerca de 70 a 80% dos casos ocorrem antes dos 20 anos de idade. Histologicamente se caracteriza pela presença de pequenas células arredondadas e azuis. Além disso, pode se manifestar em tecidos moles ou osso e em qualquer parte do corpo, sendo a forma congênita mais comumente encontrada nas extremidades. O diagnóstico é estabelecido através de exames de imagem, histopatologia e imuno-histoquímica. Esses tumores costumam ser agressivos e apresentar elevada mortalidade. Aqui, relatamos o caso de um recém-nascido que apresentou uma massa no membro superior esquerdo diagnosticada como sarcoma congênito da família Ewing por biópsia cutânea por punch e pela presença do marcador CD99 (AU)

Congenital Ewing's sarcoma is an extremely rare disease, manifested by the appearance of a mass and systemic signs such as pain and fever. About 70-80% of cases occur before 20 years of age. This condition is histologically characterized by the presence of small round blue cells and can manifest in bone or soft tissue, anywhere in the body, with the congenital form being the most commonly found in the extremities. The diagnosis is established by imaging, histopathology, and immunohistochemistry. These tumors tend to be aggressive and have high mortality rates. Here, we report the case of a newborn who presented a mass in the left upper limb diagnosed as congenital Ewing's sarcoma by punch skin biopsy and the presence of the CD99 marker (AU)

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O crescimento do número de pessoas idosas foi acompanhado por um aumento de comorbidades geradoras de imobilidade e de institucionalização. Objetivamos identificar as variáveis associadas à imobilidade e à realização das atividades básicas da vida diária (AVDs) em uma Instituição de Longa Permanência (ILPI). A média etária das idosas institucionalizadas foi de 72,8 anos, sendo 40,3% dependentes quanto a AVDs. Os fatores associados à imobilidade foram: doenças reumatológicas, gastrointestinais e incontinência urinária (p<0,05).(AU)

The increasing number of elderly has growth the prevalence of comorbidities that generate immobility and of institutionalization. We aimed identify the variables associated with immobility and performingbasic activities of daily living (AVD) on a ILP. The average age of institutionalized elderly was 72.8 years and 40.3% were dependent about the AVDs.The factors associated with immobility were: rheumatic diseases, gastrointestinal and urinary incontinence (p <0.05).(AU)

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O crescimento do número de pessoas idosas foi acompanhado por um aumento de comorbidades geradoras de imobilidade e de institucionalização. Objetivamos identificar as variáveis associadas à imobilidade e à realização das atividades básicas da vida diária (AVDs) em uma Instituição de Longa Permanência (ILPI). A média etária das idosas institucionalizadas foi de 72,8 anos, sendo 40,3% dependentes quanto a AVDs. Os fatores associados à imobilidade foram: doenças reumatológicas, gastrointestinais e incontinência urinária (p<0,05).

The increasing number of elderly has growth the prevalence of comorbidities that generate immobility and of institutionalization. We aimed identify the variables associated with immobility and performingbasic activities of daily living (AVD) on a ILP. The average age of institutionalized elderly was 72.8 years and 40.3% were dependent about the AVDs.The factors associated with immobility were: rheumatic diseases, gastrointestinal and urinary incontinence (p <0.05).

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Polyamines, including spermidine, facilitate seizures by positively modulating N-methyl-d-aspartate receptors (NMDAr). Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ)-induced seizures. Adult male Wistar rats were injected in the lateral ventricle with 0.9% NaCl (1µl, i.c.v.), spermidine (0.02, 0.2 or 2nmol/site, i.c.v.) or traxoprodil (0.2, 2 or 20nmol, i.c.v.) and with PTZ (35 or 70mg/kg, i.p.). The effect of orally administered traxoprodil (60mg/kg, p.o.) on seizures was also investigated. Latencies to clonic and generalized seizures, as well the total time spent in seizures were recorded by behavioral and electrographic methods (EEG). Spermidine (2nmol/site; i.c.v.) facilitated the seizures induced by a sub-threshold dose of PTZ (35mg/kg; i.p.), but did not alter seizure activity induced by a convulsant dose of PTZ (70mg/kg; i.p.). Traxoprodil (20nmol i.c.v.) increased the latency to generalized tonic-clonic seizures induced by PTZ (70mg/kg; i.p.). Traxoprodil (60mg/kg, p.o.) increased the latency to clonic and generalized seizures, and decreased the total time spent in seizures. These results support the role for the NR2B subunit in PTZ-induced seizures.

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