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RESUMEN Se señala la importancia de reconsiderar el trabajo de Pierre Janet en trauma y amnesia disociativa, como elementos importantes en el estudio actual del trastorno de estrés postraumático (TEPT). Los objetivos de esta revisión histórica no sistemática y comparativa son: a) explicar, desde la perspectiva de Janet: el concepto de Idea Fija, que hoy denominamos trauma b) describir los diferentes tipos de amnesia en las cuales se basa el DSM para su clasificación actual y c) a través de un caso clínico descrito por Janet, mostrar su concordancia con lo que actualmente diagnosticamos como TEPT complejo, que denominó en su época: "una de las formas que puede tomar la histeria después de un accidente emocional". Esta revisión se basa principalmente en algunos capítulos originales de Janet publicados en Francés.

The present article gives emphasis in reconsidering the work of Pierre Janet in trauma and dissociative amnesia, as important aspects for the contemporary study of posttraumatic stress disorder (PTSD). The purpose of this non systematic historical review is to explain the following ideas under Janet´s perspective: a) the concept of fixed idea, denominated in our contemporary nomenclature as trauma, b) to describe the different types of amnesia described by Janet and its relation with DSM clasiffication for this penomenon, and c) to show through the analysis of a clinical case described by Janet, how a concordance exists between the current denomination of complex PTSD and what Janet nominated "one of the forms in which hysteria can presents after an emotional accident". This article is mainly based in some original chapters from Janet´s work published in French.

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OBJECTIVE: The goal of this project was to first address barriers to implementation of the Risk Analysis Index (RAI) within a large, multi-hospital, integrated healthcare delivery system, and to subsequently demonstrate its utility for identifying at-risk surgical patients. BACKGROUND: Prior studies demonstrate the validity of the RAI for evaluating preoperative frailty, but they have not demonstrated the feasibility of its implementation within routine clinical practice. METHODS: Implementation of the RAI as a frailty screening instrument began as a quality improvement initiative at the University of Pittsburgh Medical Center in July 2016. RAI scores were collected within a REDCap survey instrument integrated into the outpatient electronic health record and then linked to information from additional clinical datasets. NSQIP-eligible procedures were queried within 90 days following the RAI, and the association between RAI and postoperative mortality was evaluated using logistic regression and Cox proportional hazards models. Secondary outcomes such as inpatient length of stay and readmissions were also assessed. RESULTS: RAI assessments were completed on 36,261 unique patients presenting to surgical clinics across five hospitals from July 1 to December 31, 2016, and 8,172 of these underwent NSQIP-eligible surgical procedures. The mean RAI score was 23.6 (SD 11.2), the overall 30-day and 180-day mortality after surgery was 0.7% and 2.6%, respectively, and the median time required to collect the RAI was 33 [IQR 23-53] seconds. Overall clinic compliance with the recommendation for RAI assessment increased from 58% in the first month of the study period to 84% in the sixth and final month. RAI score was significantly associated with risk of death (HR=1.099 [95% C.I.: 1.091 - 1.106], p < 0.001). At an RAI cutoff of ≥37, the positive predictive values for 30- and 90-day readmission were 14.8% and 26.2%, respectively, and negative predictive values were 91.6% and 86.4%, respectively. CONCLUSIONS: The RAI frailty screening tool can be efficiently implemented within multi-specialty, multi-hospital healthcare systems. In the context of our findings and given the value of the RAI in predicting adverse postoperative outcomes, health systems should consider implementing frailty screening within surgical clinics.

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Resumen En el presente reporte se destaca la importancia de explicar y conocer los orígenes del concepto de "Función de lo real" en la perspectiva de Janet. Esto, dadas sus aplicaciones actuales en el estudio del trastorno obsesivo compulsivo, las psicosis, el trastorno por estrés postraumático y los síntomas disociativos. Se define la "Función de lo real" como la aprehensión de la realidad en todas sus formas, por percepción y acción, que modifica todas las demás operaciones psicológicas. Es entonces el resultados de tres operaciones psicológicas principales, que se encuentran dentro de una jerarquía de funciones organizadas y unidas por la tensión psicológica. Como eje teórico central, es la debilidad de dicha tensión lo que provoca un deterioro de estas operaciones y una pérdida de la función de lo real, originando variados síntomas. El deterioro de dichas operaciones y los síntomas derivados son: La acción voluntaria que lleva a conductas compulsivas. La percepción con creencia reflexiva conduce a síntomas obsesivos y la creencia aseverativa a síntomas psicóticos. Personificación y presentificación, relacionada con lo que actualmente denominamos trauma y síntomas disociativos.

In the following report the author remarks the importance of explaining and knowing the origins of the concept of "Function of the real" in Janet's perspective. The importance of shed some light on this concept derives from its current applications in the study of obsessive compulsive disorder, psychosis and post-traumatic stress disorder and dissociative symptoms. The "Function of the real" or "Reality function" is defined as the apprehension of reality in all its forms. It is the result of three main psychological operations, which are within a hierarchy of functions organized and united by a property called "psychological tension". The weakness of this tension causes a deterioration of these operations and a loss of the reality function causing, as a consequence, various symptoms. The affected operations and the derived symptoms are: The voluntary action that leads to compulsive behaviors. Perception with reflective belief, which conduces to obsessive symptoms, assertive belief and psychotic symptoms. Personification and presentification, related to what we now call trauma and dissociative symptoms.

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Resumen Se destaca la importancia de conocer los orígenes del concepto de disociación en la perspectiva de Janet, dadas sus aplicaciones actuales en el estudio y tratamiento del trauma y el trastorno por estrés postraumático, entre otros temas similares. El objetivo principal de esta revisión es explicar, desde la perspectiva de Pierre Janet, el concepto de disociación en relación a: ideas fijas; estrechamiento del campo de la conciencia y debilidad de la síntesis mental. Se resume, una breve biografía de Pierre Janet, mencionando el legado y aplicaciones actuales de su psicología y psicopatología. Se describen los síntomas neurológicos funcionales, denominados en su época como histeria, desde donde surge en parte el concepto de disociación, estos son: parálisis, contracturas y anestesias, describiendo el diagnóstico del síntoma histérico a diferencia del síntoma orgánico. Podemos condensar lo referido en la siguiente definición: "disociación, es la pérdida de síntesis y asociación de las funciones psicológicas, las que se alejan de la consciencia y son relegadas al subconsciente, situaciones que ocurren debido a un estado emotivo o en forma espontánea… esto permite alejar de la conciencia dicho estado, el que es representado en variados síntomas".

In the following article the author remark the importance of recognizing the ogirin of Pierre Janet's concept of dissociation. This, due to the relevance of these ideas for the study and treatment of trauma and post traumatic stress disorder, among other pathologies. The main objective of this text is explaining from Janet's perspective, the concept of dissociation and its relation with the following concepts: "fixed ideas", "narrowed field of consciousness" and "weakness of mental synthesis". The article include a brief biography of Pierre Janet, making special emphasis in his legacy and contemporary clinical applications of his psychology and psychopathology. Furthermore, functional neurological symptoms are described. Those clinical manifestations were named in Janet's time as "hysteria", concept that could be traced historically as the starting point for the concept of dissociation. These functional symptoms are (among others): paralysis, muscular contractures and body parts anesthesia; conceptually differentiating functional symptoms from organic symptoms. An interesting form of summarising the concepts of this article is using Janet's words: "Dissociation is the lost of synthesis and association of psychological functions, displacing them away from explicit consciousness and relegating these functions to the subconscious, situations that occurring due to an emotional state or in an spontaneous way … this process facilitates the separation of the emotional states from consciousness, making possible the representation of emotions in physical symptoms".

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OBJECTIVE: To determine safety and pharmacodynamics/efficacy of teduglutide in children with intestinal failure associated with short bowel syndrome (SBS-IF). STUDY DESIGN: This 12-week, open-label study enrolled patients aged 1-17 years with SBS-IF who required parenteral nutrition (PN) and showed minimal or no advance in enteral nutrition (EN) feeds. Patients enrolled sequentially into 3 teduglutide cohorts (0.0125 mg/kg/d [n = 8], 0.025 mg/kg/d [n = 14], 0.05 mg/kg/d [n = 15]) or received standard of care (SOC, n = 5). Descriptive summary statistics were used. RESULTS: All patients experienced ≥1 treatment-emergent adverse event; most were mild or moderate. No serious teduglutide-related treatment-emergent adverse events occurred. Between baseline and week 12, prescribed PN volume and calories (kcal/kg/d) changed by a median of -41% and -45%, respectively, with 0.025 mg/kg/d teduglutide and by -25% and -52% with 0.05 mg/kg/d teduglutide. In contrast, PN volume and calories changed by 0% and -6%, respectively, with 0.0125 mg/kg/d teduglutide and by 0% and -1% with SOC. Per patient diary data, EN volume increased by a median of 22%, 32%, and 40% in the 0.0125, 0.025, and 0.05 mg/kg/d cohorts, respectively, and by 11% with SOC. Four patients achieved independence from PN, 3 in the 0.05 mg/kg/d cohort and 1 in the 0.025 mg/kg/d cohort. Study limitations included its short-term, open-label design, and small sample size. CONCLUSIONS: Teduglutide was well tolerated in pediatric patients with SBS-IF. Teduglutide 0.025 or 0.05 mg/kg/d was associated with trends toward reductions in PN requirements and advancements in EN feeding in children with SBS-IF. TRIAL REGISTRATION: ClinicalTrials.gov:NCT01952080; EudraCT: 2013-004588-30.

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We report on functional imaging results in 24 patients of Personality Disorder (P.D.) performed with NeuroSPECT by means of Tc99m HMPAO, in Basal state and during frontal cortical activation by means of the Wisconsin Card Sorting Test. Results demonstrate that we can make the diagnosis of P.D. when we detect significant hypoperfusion (- 2 Stand/ Deviations below the normal mean for the same age group) in the subgenual area (Area 25 of Brodmann) and in Area 24 of Brodmann, the anterior cingulated gyrus. Both areas are paradoxically more hypoperfused during the Wisconsin Test. Among patients diagnosed with P.D. NeuroSPECT can distinguish between patients of Cluster B from the ones from Cluster C in both Basal and Activation State, while Cluster A from B could be differentiated only in Basal State. On the other hand Motor Impulsivity patients could be differentiated from the Cognitive group due to paradoxical hypoperfusion in motor areas 1,2,3, and 4 of Brodmann. While the number of patients studied appears reduced these results demonstrate the capability of diagnosing Personality Disorder and also the capability to improved understanding of the subgroups of this Disorder.

Se comunican los resultados de 24pacientes con Trastornos de Personalidad estudiados mediante Neuro-SPECT HMPAO Tc99m, técnica de imagenología funcional cerebral en condicionas basales y durante activación de la corteza frontal ejecutiva mediante la prueba de Wisconsin. Los resultados demuestras fehacientemente que el diagnóstico de Trastorno de Personalidad se basa en la presencia de disminución de perfusión (- 2 Desviaciones Standard bajo el promedio normal para el mismo grupo etario) en el Cingulado Anterior y región subgenual, exageradas paradojalmente durante la prueba de Wisconsin. Dentro de los pacientes demostrados como Trastorno de Personalidad, Neuro-SPECT es capaz de distinguir los pacientes del Cluster B de los del Cluster C en ambos estados de medición,(Estado Basal vs Prueba de Wisconsin) mientras los Cluster A y B fueron diferenciables en estado Basal solamente. Por otra parte, la Impulsividad Motora pudo ser distinguida de la Cognitiva por la hipoperfusión paradojal de las áreas frontales de Brodmann motoras 1,2,3 y 4. Si bien el número total de pacientes reportados en este trabajo, es relativamente limitado, abre posibilidades interesantes a la imagenología funcional cerebral en estado basal y durante activación mediante la prueba de Wisconsin para el diagnóstico y exploración del Trastorno de Personalidad.

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OBJECTIVE: To establish the efficacy and best starting dose of polyethylene glycol (PEG)3350 in the short-term treatment of children with functional constipation. STUDY DESIGN: Prospective, randomized, multicenter, double-blinded, placebo-controlled, dose-ranging study of PEG3350 in children with functional constipation. Patients were randomly assigned to either placebo or 0.2 g/kg per day, 0.4 g/kg per day, or 0.8 g/kg per day of PEG3350 after a 1 week run-in period, followed by 2 weeks of treatment. All received behavior modification. The primary outcome was the proportion of patients with a successful treatment response: >or=3 bowel movements (BM) in the second week. RESULTS: 103 children (mean, 8.5 +/- 3.1 years) were enrolled. 77%, 74%, and 73% of the 0.2, 0.4, and 0.8 g/kg groups were successfully treated, as compared with 42% receiving placebo (P < .04). There was a significant increase in BM (P < .001) and straining improvement (P < .05) with the different PEG3350 doses. Stool consistency improved significantly for doses 0.4 g/kg or higher (P < .001). There was more abdominal pain and fecal incontinence in patients receiving 0.8 g/kg. PEG3350 was well tolerated. CONCLUSIONS: This placebo-controlled study confirms the efficacy and safety of PEG3350 for the short-term treatment of children with functional constipation. We recommend a starting dose of 0.4 g/kg per day.

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OBJECTIVE: To investigate the efficacy and safety of polyethylene glycol (PEG) 3350 in the treatment of childhood fecal impaction. METHODS: This was a prospective, double-blind, parallel, randomized study of 4 doses of PEG 3350; 0.25 g/kg per day, 0.5 g/kg per day, 1 g/kg per day, 1.5 g/kg per day, given for 3 days in children with constipation for >3 months and evidence of fecal impaction. RESULTS: Forty patients completed the study (27 boys, median age 7.5, range 3.3-13.1 years). Disimpaction occurred in 75% of children, with a significant difference between the two higher doses and the lower doses (95% vs 55%, P <.005). All groups had an increased number of bowel movements during the 5-day study versus baseline, respectively: 6.5 versus 1.1 (P <.005), 8.0 versus 1.3 (P <.005), 10.9 versus 1.7 (P <.005), and 12.3 versus 1.4 (P <.005). Adverse effects included nausea (5%), vomiting (5%), bloating (18%), cramping (5%), and diarrhea (13%). Diarrhea and bloating were more prevalent (P <.02) in the higher-dose than in the lower-dose group. No clinically significant changes in electrolytes were noted. CONCLUSIONS: The 3-day administration of PEG 3350 is safe and effective in the treatment of childhood fecal impaction at doses of 1 and 1.5 g/kg per day.

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Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease. An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease. Clofazimine enteropathy caused by crystal deposition can be life-threatening

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A case of acute methanol intoxication is presented, in which bilateral putaminal hemorrhage developed after hemodialysis. Even though the patient was initially comatose and profoundly acidotic, favorable outcome was achieved, with long-term neurologic impairments essentially restricted to mild crural paraparesis, retrograde amnesia, and marked visual deficit. A comparative literature review is evaluated.

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Se postula en la actualidad que la histeria de conversión, tal como fue definida por Freud, está desapareciendo. Frente a dicha afirmación el autor, a través de una amplia revisión de la literatura concluye que ésta pudo haber sido mal diagnosticada en desmedro de otras enfermedades en el pasado, y ahora mejor diagnosticada. Dicha situación puede haber llevado a una aparente disminución de ésta, pero, por las dificultades que involucran los resultados de los estudios epidemiológicos citados, no podemos inclinarnos con seguridad a afirmar que ha habido una disminución estadística real. El autor plantea además la posible transformación de la histeria conversiva pseudoneurológica, pudiendo ésta en la actualidad estar apareciendo bajo otra forma: como una histeria de conversión pseudodepresiva. Sin embargo, como el estudio es teórico y en base a una revisión bibliográfica solo de los aspectos clínicos, objeta dichas conclusiones, haciendo ver la necesidad de efectuar estudios epidemiológicos, investigaciones en pacientes y análisis de los psicodinamismos psicoanalíticos que comprueben los hechos postulados

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Las variaciones del apetito en la embarazada han sido frecuentemente consideradas como datos anecdóticos, quedando marginados al ámbito de los fenómenos sugestivos o del capricho manipulador. En las escasas publicaciones sobre la materia, resalta la inconsistencia de las definiciones de antojo, lo que impide conocer la incidencia del fenómeno y hace difícil la comparación de las distintas series. Este trabajo pretende determinar la existencia de una exaltación del apetito en las embarazadas, describir sus características y de acuerdo a éstas, obtener una definición operativa de antojo. Entrevistamos a 120 puérperas con embarazo normal de las áreas norte y occidente de Santiago, a quienes se aplicó una encuesta semicerrada con 60 preguntas acerca del apetito durante su último embarazo comparándolas con sus respectivos períodos de no embarazo. A partir de esto, encontramos 8 características estadísticamente significativas, con las que construimos una definición operativa de antojo: "Es un apetito especial, frecuente en el embarazo, urgente, difícil de postergar y sustituir, que requiere consumir una mayor cantidad de alimento para satisfacerse, que produce una satisfacción especial y que no se satisface al sustituirlo, llegando a producir malestar al no consumir lo apetecido; todos estos fenómenos sorprenden a la embarazada que los presenta"

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Se presenta el caso de una paciente diagnosticada inicialmente como Histeria de conversión, que en estudios posteriores mostró la presencia de un tumor del SNC

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