RESUMO

Serum angiotensin-I-converting enzyme activity was found to be elevated in infants with idiopathic respiratory distress syndrome when compared with healthy premature infants, normal infants, and acutely ill full-term infants. Serum and lung CE activity has been found to be elevated in mice exposed to hypobaric alveolar hypoxia which also stimulated renal renin production. These findings suggest that alveolar hypoxia stimulates the renin-angiotensin-aldosterone system and this system may be involved in the response to the stress of IRDS.

Assuntos

Hipóxia/enzimologia , Pulmão/enzimologia , Peptidil Dipeptidase A/sangue , Síndrome do Desconforto Respiratório do Recém-Nascido/enzimologia , Fatores Etários , Animais , Peso ao Nascer , Feminino , Humanos , Recém-Nascido , Sistema Justaglomerular/fisiopatologia , Pulmão/patologia , Camundongos , Peptidil Dipeptidase A/análise , Renina/sangue , Síndrome do Desconforto Respiratório do Recém-Nascido/sangue