RESUMO
Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Recent studies have suggested that aberrant innate immunity is central to this disease. The aim of this study was to examine the presence of Langerhans cells, plasmacytoid dentritic cells (PDC), the expression of Toll-like receptors (TLR) and inducible oxide nitric synthase (iNOS) in skin of patients with rosacea, to highlight the participation of innate immunity in its pathogenesis. 28 biopsy specimens were taken from patients with clinical and histopathological findings of rosacea. Immunohistochemical demonstration of Langerhans cells (anti-CD1a antibody), PDC (anti-CD 123 antibody), TLR2, TLR4 and iNOS was performed in skin samples and compared with normal skin controls. The expression of Langerhans cells was lower in rosacea group than in control group. PDC were found in skin samples of rosacea as isolated cells and forming small clusters. Expression of TLR2, TLR4 and iNOS was higher in rosacea samples than in normal skin controls. This research demonstrates early and late stage components of innate immunity in specimens of rosacea ratifying the existence of an altered innate immunity in its pathogenesis.
Assuntos
Imunidade Inata , Óxido Nítrico Sintase Tipo II/metabolismo , Rosácea/imunologia , Receptor 2 Toll-Like/metabolismo , Receptor 4 Toll-Like/metabolismo , Adulto , Idoso , Biópsia , Estudos de Casos e Controles , Células Dendríticas/imunologia , Feminino , Humanos , Células de Langerhans/imunologia , Masculino , Pessoa de Meia-Idade , Óxido Nítrico Sintase Tipo II/imunologia , Qualidade de Vida , Rosácea/patologia , Pele/citologia , Pele/imunologia , Pele/patologia , Receptor 2 Toll-Like/imunologia , Receptor 4 Toll-Like/imunologiaRESUMO
Leprosy is an important public health problem in Brazil. However, this disease is still poorly diagnosed in its early stages, leading to permanent disability and disfigurement. We examined eight patients with clinical and histologicaldiagnosis of multibacillary leprosy who were being treated for other diseases for about three years without clinicalhypothesis of leprosy. These cases illustrate the importance of medical education and public information aboutleprosys signs and symptoms for prompt recognition and treatment, which are necessary to prevent permanentdisabilities and eradicate the disease.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Diagnóstico Tardio , Hanseníase Multibacilar/diagnósticoRESUMO
Leprosy is an important public health problem in Brazil. However, this disease is still poorly diagnosed in its early stages, leading to permanent disability and disfigurement. We examined eight patients with clinical and histological diagnosis of multibacillary leprosy who were being treated for other diseases for about three years without clinical hypothesis of leprosy. These cases illustrate the importance of medical education and public information about leprosy's signs and symptoms for prompt recognition and treatment, which are necessary to prevent permanent disabilities and eradicate the disease.