RESUMO
Pseudocistos perirenais são caracterizados pelo acúmulo de variáveis quantidades de fluido em voltade um ou ambos os rins, delimitados por estrutura fibrosa, com ausência de camada epitelial. Estelíquido perirenal pode acumular-se de forma intracapsular ou extracapsular, sendo o transudato oprincipal tipo de fluido que preenche a cavidade cística.Sua etiopatogenia permanece obscura, masacredita-se que esteja relacionada com a falência renal crônica, ocorrendo com maior frequência emgatos idosos. Este trabalho relata um caso de pseudocisto perirenal bilateral com acúmulo extracapsularde transudato, em um gato doméstico de pelo curto. O diagnóstico presuntivo foi baseado nosachados clínicos, laboratoriais e ultra-sonográficos que revelaram acúmulo de líquido perirenal bilateral,assim como alterações na arquitetura e função renal. Embora a histopatologia não tenha sido empregadapara complementar o diagnóstico, os achados macroscópicos evidenciados na laparotomiaexploratória serviram para fundamentá-lo.
Perinephric pseudocysts are characterized by the accumulation of varying amounts of fluid aroundone or both kidneys, surrounded by fibrous structure, with absence of epithelial layer. This perirenalfluid can accumulate so intra or extracapsular, and been the transudation the main type of fluid thatfills the cystic cavity. The etiopathogenesis remains poorly informed, but it is believed that their originis linked with chronic renal failure, occurring more frequently in older cats. This paper reports acase of bilateral perirenal pseudocyst with accumulation of extracapsular transudation in a domesticshort hair cat. Presumptive diagnosis was based on clinical, laboratory and ultrasound findings thatshowed accumulation of bilateral perirenal fluid, as well as changes in the architecture and renalfunction. Although the histopathology has not been used to establish the diagnosis, the macroscopicfindings highlighted in exploratory laparotomy were used for that finality.
Assuntos
Animais , Gatos , Cistos/veterinária , Gatos , LaparotomiaRESUMO
Pseudocistos perirenais são caracterizados pelo acúmulo de variáveis quantidades de fluido em voltade um ou ambos os rins, delimitados por estrutura fibrosa, com ausência de camada epitelial. Estelíquido perirenal pode acumular-se de forma intracapsular ou extracapsular, sendo o transudato oprincipal tipo de fluido que preenche a cavidade cística.Sua etiopatogenia permanece obscura, masacredita-se que esteja relacionada com a falência renal crônica, ocorrendo com maior frequência emgatos idosos. Este trabalho relata um caso de pseudocisto perirenal bilateral com acúmulo extracapsularde transudato, em um gato doméstico de pelo curto. O diagnóstico presuntivo foi baseado nosachados clínicos, laboratoriais e ultra-sonográficos que revelaram acúmulo de líquido perirenal bilateral,assim como alterações na arquitetura e função renal. Embora a histopatologia não tenha sido empregadapara complementar o diagnóstico, os achados macroscópicos evidenciados na laparotomiaexploratória serviram para fundamentá-lo.(AU)
Perinephric pseudocysts are characterized by the accumulation of varying amounts of fluid aroundone or both kidneys, surrounded by fibrous structure, with absence of epithelial layer. This perirenalfluid can accumulate so intra or extracapsular, and been the transudation the main type of fluid thatfills the cystic cavity. The etiopathogenesis remains poorly informed, but it is believed that their originis linked with chronic renal failure, occurring more frequently in older cats. This paper reports acase of bilateral perirenal pseudocyst with accumulation of extracapsular transudation in a domesticshort hair cat. Presumptive diagnosis was based on clinical, laboratory and ultrasound findings thatshowed accumulation of bilateral perirenal fluid, as well as changes in the architecture and renalfunction. Although the histopathology has not been used to establish the diagnosis, the macroscopicfindings highlighted in exploratory laparotomy were used for that finality.(AU)
Assuntos
Animais , Gatos , Gatos , Cistos/veterinária , LaparotomiaRESUMO
The modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic lesion) was investigated in adult male Wistar rats. Six groups of animals were used. Groups 2 to 5 were given a single i.p. injection of 200 mg/kg b.w. of diethylnitrosamine (DEN) and groups 1 and 6 were treated with saline at the beginning of the experiment. After 2 weeks, animals of groups 3 to 6 were orally treated with three dose levels of aqueous extracts of the mushroom A. blazei (1.2, 5.6, 11.5, and 11.5 mg/ml of dry weight of solids) for 6 weeks. All animals were subjected to two-thirds partial hepatectomy at week 3 and sacrificed at week 8. Two hours before sacrifice, ten animals of each group were administered a single i.p injection of 100 mg/kg of bromodeoxyuridine (BrdU). Apoptotic bodies and BrdU-positive hepatocyte nuclei were quantified in liver sections stained for hematoxylin and eosin (H&E) (eosinophilic foci) and simultaneously stained for GST-P expression (GST-P-positive foci), respectively. The 6-week treatment with A. blazei did not alter the development (number and size) of GST-P-positive foci and did not affect the growth kinetics of liver normal parenchyma or foci in DEN-initiated animals. Our results indicate that the treatment with aqueous extracts of the mushroom A. blazei during the post-initiation stage of rat liver carcinogenesis does not exert any protective effect against the development of GST-P-positive foci induced by DEN.