RESUMO
Background and Objectives: Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) is a form of chronic kidney disease of undetermined etiology (CKDu) and is not associated with traditional risk factors. The aim of this study was to investigate the association of polymorphisms rs2070744, 4b/a and rs1799983 of the NOS3 gene with CKDnT in Mexican patients. Materials and Methods: We included 105 patients with CKDnT and 90 controls. Genotyping was performed by PCR-RFLP's, genotypic and allelic frequencies were determined and compared between the two groups using χ2 analysis, and differences were expressed as odd ratios with 95% confidence intervals (CI). Values of p < 0.05 were considered statistically significant. Results: Overall, 80% of patients were male. The rs1799983 polymorphism in NOS3 was found to be associated with CKDnT in the Mexican population (p = 0.006) (OR = 0.397; 95% CI, 0.192-0.817) under a dominant model. The genotype frequency was significantly different between the CKDnT and control groups (χ2 = 8.298, p = 0.016). Conclusions: The results of this study indicate that there is an association between the rs2070744 polymorphism and CKDnT in the Mexican population. This polymorphism can play an important role in the pathophysiology of CKDnT whenever there is previous endothelial dysfunction.
Assuntos
Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Humanos , Masculino , Feminino , Predisposição Genética para Doença/genética , Polimorfismo de Nucleotídeo Único/genética , Óxido Nítrico Sintase Tipo III/genética , Estudos de Casos e Controles , GenótipoRESUMO
An investigation of the tectonic controls of the fluvial morphology and sedimentary processes of an area located southwest of Manaus in the Amazon Basin was conducted using orbital remote sensing data. In this region, low topographic gradients represent a major obstacle for morphotectonic analysis using conventional methods. The use of remote sensing data can contribute significantly to overcome this limitation. In this instance, remote sensing data comprised digital elevation model (DEM) acquired by the Shuttle Radar Topographic Mission (SRTM) and Landsat Thematic Mapper images. Advanced image processing techniques were employed for enhancing the topographic textures and providing a three-dimensional visualization, hence allowing interpretation of the morphotectonic elements. This led to the recognition of main tectonic compartments and several morphostructural features and landforms related to the neotectonic evolution of this portion of the Amazon Basin. Features such as fault scarps, anomalous drainage patterns, aligned ridges, spurs and valleys, are expressed in the enhanced images as conspicuous lineaments along NE-SW, NW-SE, E-W and N-S directions. These features are associated to the geometry of alternated horst and graben structures, the latter filled by recent sedimentary units. Morphotectonic interpretation using this approach has proven to be efficient and permitted to recognize new tectonic features that were named Asymmetric Ariaú Graben, Rombohedral Manacapuru Basin and Castanho-Mamori Graben.
Uma investigação do controle tectônico da morfologia fluvial e dos processos sedimentares de uma área localizada a sudoeste da cidade de Manaus, na Bacia do Amazonas, foi conduzida a partir do uso de dados de sensores remotos orbitais. Nessa região, o baixo gradiente topográfico representa o principal obstáculo para a análise morfotectônica usando métodos convencionais. O uso de dados de sensores remotos pode contribuir significativamente para superar essa limitação. Desse modo, dados de sensoriamento remoto, compreendendo modelo digital de elevação (DEM) obtido pelo Shuttle Radar Topographic Mission (SRTM) e imagens Landsat TM, foram utilizados para essa investigação. Técnicas avançadas de processamento de imagem foram empregadas para realce de imagens topográficas e sua elaboração tridimensional, permitindo desse modo, a interpretação dos elementos morfotectônicos. Isso permitiu o reconhecimento de principais compartimentos tectônicos, diversas feições morfoestruturais e formas de relevo relacionadas à evolução neotectônica dessa porção da Bacia do Amazonas. Feições como escarpas de falha, padrão anômalo na drenagem, alinhamentos de relevo, vales e divisores d'água foram realçados nas imagens como notáveis lineamentos ao longo das direções NE-SW, NW-SE, E-W e N-S. Essas feições foram associadas à geometria de estruturas do tipo horste e gráben alternados, este último preenchido por unidades sedimentares recentes. A interpretação morfotectônica usando essa técnica mostrou-se eficiente e permitiu o reconhecimento de novas feições tectônicas as quais foram denominadas de Gráben Assimétrico Ariaú, Bacia Romboédrica de Manacapuru e Gráben Castanho-Mamori.
RESUMO
The well productivity in crystalline terrains is extremely changeable and depends on external factors, in addition to the intrinsic properties of rocks. In the Jundiaí River Catchment, Southeastern Brazil, the main factor that influences well productivity is the existence of open discontinuities permeability in geologic environments that favor groundwater recharge. In that area, Pre-Cambrian shear and fault zones were reactivated throughout geologic time, controlling the morphostructural compartments and the Cenozoic sedimentary deposition. Superposition of productivity data and structural maps showed that more productive wells are concentrated mainly along the regional geologic structures. The structural control over well productivity is also noticeable in detailed scale. Using fine scale maps we show that the most productive wells are located in areas where brittle structures with NW-SE and E-W directions denote the action of neotectonic transtensional stress. The comprehension of evolutionary geologic history allied to fracturing analysis proved to be an efficient and a low cost technique, which is adequate for selecting areas for further developments using more expensive methods.