RESUMO
A number of crude extracts from folk medicinal plants were screened for cytotoxicity against the human T-cell leukemia cell line. Fixed aliquots from a quantified cell suspension were incubated for three days in the presence of a control and several different concentrations of the given plant extract
Assuntos
Humanos , Azadirachta , Leucemia de Células T , Plantas Medicinais , Trinidad e TobagoRESUMO
A new sesquiterpene derivative named mochiquinone (1) was isolated from the Caribbean gorgonian coral Pseudopterogorgia rigida collected off northeastern Venezuela, along with the known compounds, alpha-curcumene, (-)-curcuphenol, (-)-curcuquinone, and (-)-curcuhydroquinone. The structure of the new compound was determined by spectroscopic analysis of its acetylated derivative and comparison with known compounds.
Assuntos
Cnidários/química , Sesquiterpenos/química , Acetilação , Animais , Região do Caribe , Cromatografia em Camada Fina , Espectroscopia de Ressonância Magnética , Sesquiterpenos/isolamento & purificação , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Three new monotetrahydrofuran (mono-THF) acetogenins, anmontanins A-C (1-3) were isolated from the leaves of Annona montana. Anmontanin C (3) is the first stereochemically pure acetogenin reported to have a gamma-hydroxymethyl-gamma-lactone moiety. Two known mono-THF acetogenins, murisolin and annonacin, were isolated from the seeds of the plant. The structures of compounds 1-3 were elucidated by spectral methods and chemical derivatization.
Assuntos
Furanos/isolamento & purificação , Lactonas/isolamento & purificação , Árvores/química , Furanos/química , Lactonas/química , Espectroscopia de Ressonância Magnética , Modelos Químicos , Folhas de Planta/química , Espectrometria de Massas de Bombardeamento Rápido de ÁtomosRESUMO
A previously isolated trihydroxy-gorgosterol derivative (2), a new gorgosterol (3), and the known sterol cholestane-3beta,5alpha, 6beta-triol are reported from the Caribbean octocoral Eunicea laciniata collected off northeast Venezuela. Using high-resolution 2D NMR techniques, the total structural assignment and detailed stereochemistry of 2 is presented for the first time and the full structure of 3 advanced.
Assuntos
Colestanóis/isolamento & purificação , Colesterol/análogos & derivados , Colesterol/isolamento & purificação , Cnidários/química , Animais , Colestanóis/química , Colestanóis/farmacologia , Colesterol/química , Estrutura Molecular , Análise EspectralRESUMO
A number of crude extracts from folk medicinal plants were screened for cytotoxicity against the human T-cell leukemia cell line. Fixed aliquots from a quantified cell suspension were incubated for three days in the presence of a control and several different concentrations of the given plant extract