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1.
Toxicol Rep ; 7: 1487-1494, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33204649

RESUMO

Phthalates are widely used as plasticizers, additives, or solvents. Its extensive use has generated environmental and food contamination, which implies continuous population exposure. The aim of this work was to determine the probability of health risk of Mexican children exposed to phthalates through the consumption of contaminated food. A survey was applied to 384 Mexican school-age children (between 6 and 12 years old), to find out the type of food they eat most frequently, based on this, a research was made to know the concentration of phthalates contained in these foods. The daily intake had been calculated with the concentration of phthalates reported in food, obtaining: DEHP (19.50 µg/kg body weight/day), DnBP (5.52 µg/kg body weight/day) y for DEP (1.12 µg/kg body weight/day). The hazard index (HI) for DEP y DEHP was 0.49 to 42.5 for internal organs damage reported. HI for reproductive health damage due to exposure to DnBT and DEHP was of 0.04 to 5.58, so that there is a high probability that children's health is at risk. Therefore, it is necessary to a quantitative analysis of phthalates in food consumed in Latin American countries and establish the TDI of phthalates especially, to DEHP, which was obtained the higher HI.

2.
Ciênc. Saúde Colet. (Impr.) ; Ciênc. Saúde Colet. (Impr.);15(supl.1): 1169-1174, jun. 2010. tab
Artigo em Espanhol | LILACS | ID: lil-555648

RESUMO

Los productos en desarrollo y los niños son particularmente vulnerables a los tóxicos ambientales. Nuestro objetivo es determinar los niveles de plaguicidas organoclorados (HCB, ß-HCH, pp'DDT, op'DDT y pp'DDE) en lípidos séricos de madres de niños con criptorquidia y comparar los niveles con un grupo control de madres de niños con testículos descendidos. El grupo de los casos fue constituido por recién nacidos con diagnóstico de criptorquidia (n=41). El grupo control (n=41) se conformó por niños con testículos descendidos. A las madres de ambos grupos se les determinaron los niveles de plaguicidas organoclorados. La criptorquidia fue diagnosticada al nacimiento por neonatólogo. Residuos de plaguicidas organoclorados fueron encontrados en lípidos séricos de ambos grupos. Los niveles de la mediana (mgkg-1 en base lipídica) fueron mayores para los metabolitos pp'DDT (0.464 vs. 0.269) y ß-HCH (0.263 vs. 0.192) en el grupo con criptorquidia comparado con el grupo control. (p<0.01). Los niveles de los metabolitos pp'DDT y ß-HCH son mayores entre las madres de los recién nacidos con criptorquidia. Es posible que sustancias con efectos antiandrogénicos puedan producir disrupción endocrina y criptorquidia durante el desarrollo fetal.


Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ß-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ß-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ß-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development.


Assuntos
Feminino , Humanos , Recém-Nascido , Masculino , Criptorquidismo/induzido quimicamente , Hidrocarbonetos Clorados/toxicidade , Exposição Materna/efeitos adversos , Praguicidas/toxicidade , Criptorquidismo/epidemiologia , Hidrocarbonetos Clorados/sangue
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