RESUMO

Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]-5-nitro-1,2-phenylene diacetate (10) showed higher cytotoxicity than the parent compound 2 in tests performed on two breast cancer cell lines (MCF-7 and MDA-MB-231). The IC50 values of 40.2 ± 6.9 µM, 5.9 ± 0.8 µM and 33.8 ± 4.9 µM, respectively, were obtained without toxicity towards dermal human fibroblast (DHF cells).

Assuntos

Catecóis/farmacologia , Safrol/análogos & derivados , Safrol/farmacologia , Neoplasias da Mama/patologia , Catecóis/síntese química , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Feminino , Humanos , Safrol/síntese química