RESUMO
A fasciite nodular é um tumor benigno, decorrente da proliferação reativa de células fibroblásticas ou miofibroblásticas de rápido crescimento e rica celularidade. Em adultos, o acometimento das extremidades é mais frequente; entretanto, outras regiões podem ser acometidas. Neste relato, é apresentada paciente feminina de 40 anos, com lesão nodular na fronte, com diagnóstico de fasciite nodular confirmado à histopatologia. O caso relatado procura destacar sua rara localização e alertar o dermatologista clínico para a sua inclusão entre os diagnósticos diferenciais das lesões tumorais na face.
Nodular fasciitis is a benign tumor resulting from the reactive proliferation of fibroblastic or myofibroblastic cells presenting rapid growth and rich cellularity. In adults, the extremities' involvement is more frequent; however, other regions can be affected. In this report, we present the case of a 40-year-old woman with a nodular lesion on the forehead. The histopathology confirmed the diagnosis of nodular fasciitis. The reported case highlights its rare location and alerts the clinical dermatologist in its inclusion among the differential diagnoses of tumor lesions on the face.
Assuntos
Humanos , Feminino , Adulto , Fasciite , Testa , Dermatopatias , Diagnóstico Diferencial , Face , NeoplasiasRESUMO
Background: Leprosy is a major public health concern in many developing countries. Mycobacterium leprae (M. leprae), the causative agent of leprosy, has the ability to parasitize different types of human cells and tissues. In this article, the uncommon parasitism of nevus and neoplastic and epithelial cells by M. leprae are described using histological sections doubly stained by Fite-Faraco (FF) and immunohistochemistry (IHC), respectively. Case presentation: Three patients with borderline-lepromatous and lepromatous leprosy underwent excision of melanocytic nevi (cases 12) and basal cell carcinoma (case 3). Histological sections confirmed the clinical diagnosis of melanocytic nevus and basal cell carcinoma, but leprosy lesions were evident in adjacent tissues. FF staining and IHC (CD68, Melan A, and 34ßE12) demonstrated the presence of bacilli within the nevus cells and also in the epithelial cells of the basal cell carcinoma. Conclusions: M. leprae has the ability to parasitize different types of cells, including neoplastic cells. Pathologists working in settings where leprosy is endemic should be aware that some cutaneous biopsy specimens may also present with leprosy findings.