RESUMO
RESUMEN Las metástasis cutáneas (MC) constituyen una manifestación infrecuente de neoplasias internas. Su diagnóstico requiere un alto índice de sospecha clínica, pues los hallazgos pueden ser sutiles. Estas ponen de manifiesto la presencia de un tumor maligno diseminado y pueden permitir el diagnóstico de neoplasias internas no conocidas, o indicar la diseminación o recurrencia de otras ya diagnosticadas. La MC del carcinoma de ovario suele aparecer en enfermedad avanzada e indican un mal pronóstico.Su reconocimiento temprano puede llevar a un diagnóstico preciso y rápido, con el consiguiente tratamiento oportuno, aunque en la mayoría de los casos son indicativas de un pronóstico infausto.
SUMMARY Cutaneous metastases are an infrequent manifestation of internal neoplasms. Its diagnosis requires a high index of clinical suspicion, since the findings can be subtle. These reveal the presence of a disseminated malignant tumor and can allow the diagnosis of unknown internal neoplasms, or indicate the dissemination or recurrence of others already diagnosed. MC of ovarian carcinoma usually appears in advanced disease and may indicate a poor prognosis. Early recovery can carry out an accurate and rapid diagnosis, with timely emergency treatment, although in most cases they are indicators of an unfortunate prognosis.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias Ovarianas/complicações , Neoplasias Cutâneas/diagnóstico , Metástase Neoplásica/diagnóstico , Adenocarcinoma/complicaçõesRESUMO
Serum angiotensin-I-converting enzyme activity was found to be elevated in infants with idiopathic respiratory distress syndrome when compared with healthy premature infants, normal infants, and acutely ill full-term infants. Serum and lung CE activity has been found to be elevated in mice exposed to hypobaric alveolar hypoxia which also stimulated renal renin production. These findings suggest that alveolar hypoxia stimulates the renin-angiotensin-aldosterone system and this system may be involved in the response to the stress of IRDS.
Assuntos
Hipóxia/enzimologia , Pulmão/enzimologia , Peptidil Dipeptidase A/sangue , Síndrome do Desconforto Respiratório do Recém-Nascido/enzimologia , Fatores Etários , Animais , Peso ao Nascer , Feminino , Humanos , Recém-Nascido , Sistema Justaglomerular/fisiopatologia , Pulmão/patologia , Camundongos , Peptidil Dipeptidase A/análise , Renina/sangue , Síndrome do Desconforto Respiratório do Recém-Nascido/sangueRESUMO
The clinical histories of two infants who had severe hypertension and stenoses of the renal arteries are reported. In both children blood pressure fell significantly after surgical correction of renal ischemia. However, both infants had persistent mild hypertension for several months after surgical treatment. Similar results were found in other infants with renovascular hypertension, reported previously (11 cases). The mortality rate in this total group of 13 infants reviewed was high if renal ischemia was not corrected surgically (4/4). The reason why some infants have persistent hypertension after apparently adequate surgical relief of renal ischemia is not known.