RESUMO

To assess the immunologic status of healthy persons with hemophilia A, we performed studies of T cell immunity in 21 patients, 10 given only cryoprecipitate and 11 given factor VIII concentrate. Patients in the factor VIII group had significantly decreased helper/suppressor T cell ratios. Both groups had diminished mononuclear cell response to phytohemagglutinin and normal mixed lymphocyte culture, compared with controls. Abnormalities in T cell number or function did not correlate with the presence of antibody to cytomegalovirus, Epstein-Barr virus, or hepatitis B. Physicians caring for patients with hemophilia A should realize that asymptomatic individuals may have early evidence of immunodeficiency.

Assuntos

Hemofilia A/imunologia , Síndrome da Imunodeficiência Adquirida/imunologia , Adolescente , Anticorpos Antivirais/análise , Criança , Pré-Escolar , Crioglobulinas/uso terapêutico , Fator VIII/uso terapêutico , Feminino , Humanos , Imunidade Celular , Lactente , Contagem de Leucócitos , Ativação Linfocitária , Masculino , Linfócitos T/imunologia