RESUMO
The seroprevalence of antibodies against human T-cell leukemia virus was determined by ELISA in 68 patients with filarial infestation living in an endemic area. The total seropositivity was 2.9% and the HTLV-1-positive cases were detected in 2 microfilaremic patients 12 and 40 years old. This value is very close to that obtained for healthy individuals in the same region and age groups. This result suggests that there is no relationship between filariasis and HTLV-1 infection as previously proposed.
Assuntos
Filariose/complicações , Anticorpos Anti-HTLV-I/análise , Infecções por HTLV-I/etiologia , Adolescente , Adulto , Brasil , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Filariose/imunologia , Filariose/virologia , Infecções por HTLV-I/imunologia , Humanos , Lactente , Recém-Nascido , Testes SorológicosRESUMO
The seroprevalence of human T cell leukemia virus type 1 (HTLV-1) infection was investigated in Brazilians (570): native inhabitants (298) and descendants from Japanese (272) living in Recife and its neighborhoods--North-east of Brazil. Furthermore, polytransfused renal transplanted patients (54) were also examined for the serological status to this virus. The seropositivity to HTLV-1, screened by enzyme-linked immunosorbent assay (ELISA), was low: 1.34% for the local population and 0.73% for the descendants from Japanese. However, the seropositivity for the renal transplanted patients was found to be 11.1%. This higher value suggests that this retrovirus infection seems to be of importance in this clinical condition.
Assuntos
Anticorpos Anti-HTLV-I/análise , Infecções por HTLV-I/imunologia , Transplante de Rim/imunologia , Adolescente , Adulto , Idoso , Brasil/epidemiologia , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Feminino , Infecções por HTLV-I/epidemiologia , Humanos , Imunoglobulina G/análise , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , PrevalênciaRESUMO
The seroprevalence of antibodies against cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human T cell leukemia virus type 1 (HTLV-1), determined by ELISA and by fluorescence in 54 renal transplanted patients, was 96.2%, 88.8% and 11.1%, respectively. These values are relatively high when compared with the results obtained for healthy individuals of the same age groups from Recife, Northeastern Brazil. Active CMV infection was detected by the presence of IgM antibodies and/or virus isolation in 13 (24%) patients. Kidney rejection and renal dysfunction were observed in 11 of these 13 patients, whereas 3 of 6 HTLV-1 antibody-positive individuals presented these complications. All HTLV-1 positive patients were also positive to IgG CMV and HHV-6 antibodies. The importance of the three viruses in this clinical condition is suggested by the high seropositivity rates compared with the healthy population. The group may also represent a potential source of HTLV-1 infection in this non-endemic area.
Assuntos
Infecções por Citomegalovirus/epidemiologia , Infecções por HTLV-I/epidemiologia , Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 6/isolamento & purificação , Transplante de Rim , Adolescente , Adulto , Anticorpos Antivirais/sangue , Brasil/epidemiologia , Ensaio de Imunoadsorção Enzimática , Imunofluorescência , Herpesvirus Humano 6/imunologia , Humanos , Pessoa de Meia-Idade , PrevalênciaRESUMO
The seroprevalence of antibodies against cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human T cell leukemia virus type 1 (HTLV-1), determined by ELISA and by fluorescence in 54 renal transplanted patients, was 96.2 per cent , 88.8 per cent and 11.1 per cent , respectively. These values are relatively high when compared with the results obtained for healthy individuals of the same age groups from Recife, Northeastern Brazil. Active CMV infection was detected by the presence of IgM antibodies and/or virus isolation in 13 (24 per cent ) patients. Kidney rejection and renal dysfunction were observed in 11 of these 13 patients, whereas 3 of 6 HTLV-1 antibody-positive individuals presented these complications. All HTLV-1 positive patients were also positive to IgG CMV and HHV-6 antibodies. The importance of the three viruses in this clinical condition is suggested by the high seropositivity rates compared with the healthy population. The group may also represent a potential source of HTLV-1 infection in this non-endemic area
Assuntos
Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Infecções por Citomegalovirus/epidemiologia , Herpesvirus Humano 6/isolamento & purificação , Infecções por Herpesviridae/epidemiologia , Infecções por HTLV-I/epidemiologia , Transplante de Rim , Anticorpos Antivirais/sangue , Brasil/epidemiologia , Ensaio de Imunoadsorção Enzimática , Imunofluorescência , Herpesvirus Humano 6/imunologia , PrevalênciaAssuntos
Infecções por Citomegalovirus/epidemiologia , Adolescente , Adulto , Idoso , Anticorpos Antivirais/análise , Brasil/epidemiologia , Criança , Pré-Escolar , Citomegalovirus/imunologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Gravidez , Estudos SoroepidemiológicosRESUMO
The seroprevalence of human herpesvirus 6 (HHV-6) infection was examined for 434 Brazilians and 250 Japanese immigrants living in Recife and its vicinity, in the North-East of Brazil. A total of 684 sera from the healthy individuals were screened for IgG antibodies to HHV-6 by anticomplement immunofluorescence (ACIF) test. The seropositivity rate to HHV-6 showed little difference between the two groups: namely, it was 76.5% for Brazilians and 77.2% for Japanese immigrants. The seropositivity rate was constantly higher in females than in males. The high prevalence of anti-HHV-6 antibodies among children indicates that HHV-6 infection occurs very early in life.
Assuntos
Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 6/isolamento & purificação , Adolescente , Adulto , Idoso , Anticorpos Antivirais/sangue , Brasil/epidemiologia , Criança , Pré-Escolar , Feminino , Herpesvirus Humano 6/imunologia , Humanos , Imunoglobulina G/sangue , Lactente , Japão/etnologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos SoroepidemiológicosAssuntos
Anticorpos Antivirais/análise , Infecções por Citomegalovirus/epidemiologia , Citomegalovirus/imunologia , Adolescente , Adulto , Brasil/epidemiologia , Feminino , Humanos , Recém-Nascido , Gravidez , Complicações Infecciosas na Gravidez/epidemiologia , Prevalência , Fatores SocioeconômicosRESUMO
The serological status to cytomegalovirus (CMV) was examined for 616 Brazilians and 399 Japanese immigrants living in the North-East of Brazil. The sera were screened for IgG antibodies to CMV by enzyme-linked immunosorbent assay (ELISA). The overall prevalence of CMV antibodies was higher in the Japanese population (83.7%) than in the Brazilian population (69.8%). The seropositivity was analyzed by factors of age, sex, ethnic background, and socioeconomic status. Mother-baby contact seems to be a factor of significance in the seroepidemiology of CMV infection.