RESUMO
The objective of this study is to investigate the effects of a moderate intensity physical training protocol, on alveolar bone morphology of rats submitted to ligature-induced periodontitis. Twenty-eight male Wistar rats were divided into four groups, considering the presence/absence of periodontitis and presence/absence of training. The training protocol was performed on a treadmill, 30 min/day, 5 days a week, for 4 weeks. In the experimental periodontal breakdown, with/without training, ligatures were placed on the lower first molars on the 14th day of the experiment, and were followed until the end of the protocol. At the end of the experiment, animals were euthanized and samples of plasma and mandibles were collected for immunoenzymatic evaluation of interleukins (IL)-1ß, IL-6, TNF-α and IL-10, evaluation of serum concentrations of C-reactive protein, analysis of lipid peroxidation (LPO) and reduced glutathione, histological and microtomographic analyses were performed. Physical training resulted in a reduced levels of IL-1ß, IL-6, TNF-α C-reactive protein and LPO and an increase in the levels of IL-10 in rats with periodontitis (p<0.05); a reduction in the inflammatory infiltrate and decreased fiber degradation was identified in histological analysis. Additionally, it was shown a decrease in vertical bone loss and an increase in the bone volume/trabecular volume ratio was identified in periodontitis+physical training group (p<0.05). Based on the results, the practice of frequent physical exercise, at moderate intensity, can contribute to the reduction of damage related to the disproportionate inflammatory response in periodontitis.
Assuntos
Peroxidação de Lipídeos , Estresse Oxidativo , Periodontite , Condicionamento Físico Animal , Ratos Wistar , Animais , Periodontite/metabolismo , Periodontite/patologia , Masculino , Ratos , Proteína C-Reativa/metabolismo , Perda do Osso Alveolar/patologia , Perda do Osso Alveolar/metabolismo , Glutationa/metabolismo , Modelos Animais de Doenças , Fator de Necrose Tumoral alfa/sangue , Fator de Necrose Tumoral alfa/metabolismo , Citocinas/metabolismo , Citocinas/sangueRESUMO
Orthodontic adhesives with antimicrobial and remineralizing properties may be an alternative to control white spot lesions around brackets. The aim of this study is to develop an experimental orthodontic adhesive containing boron nitride nanotubes (BNNT) and alkyl trimethyl ammonium bromide (ATAB). Methacrylate (BisGMA and TEGDMA) monomers were used to formulate the adhesives. Four experimental groups were produced with the addition of 0.1 wt.% BNNT (GBNNT); 0.1 wt.% ATAB (GATAB); and 0.2 wt.% BNNT with ATAB (GBNNT/ATAB); in the control group, no fillers were added (GCtrl). The degree of conversion, cytotoxicity, softening in solvent, contact angle and free surface energy, antibacterial activity, shear bond strength, and mineral deposition were evaluated. Adhesives achieved degree of conversion higher than 50% and cell viability higher than 90%. GBNNT and GATAB adhesives exhibited reduced softening in solvent. Mean free surface energy was decreased in the GBNNT adhesive. Significant reduction in bacterial growth was observed in the GBNNT/ATAB. No statistical difference was found for shear bond strength. Mineral deposition was found in GBNNT, GATAB, and GBNNT/ATAB groups after 14 and 28 days. The addition of 0.2% BNNT/ATAB to an experimental orthodontic adhesive inhibited bacterial growth and induced mineral deposition without affecting the properties of the material.
RESUMO
Objetivo: o presente estudo tem por objetivo avaliar a influência da adição de diferentes concentrações de subnitrato de bismuto (SN) nas propriedades de mate-riais para base protética. Materias e método: foi adicio-nada 0%, 1%, 2%, 5%, 10% e 20% de SN em peso em resina acrílica autopolimerizável da marca Clássico e submetidos aos ensaios de resistência à flexão, micro-dureza Knoop, radiopacidade, análise antimicrobiana, rugosidade e caracterização em micro-Raman. O teste estatístico escolhido foram o ANOVA de uma via e o teste de comparações múltiplas de Tukey. O nível de significância foi de 5% para todos os testes. Resultados: os resultados de resistência à flexão atingiram valores acima do recomendado pela ISO 1567. Quanto maior a concentração da carga de SN maior o valor de mi-crodureza Knoop, sendo estatisticamente significativo em 10% e 20% (p<0,001); os resultados da rugosidade mostraram valores abaixo do limiar, 0,2 µm. A adição de subnitrato de bismuto não obteve um potencial an-timicrobiano, mas apresentou uma maior radiopacida-de, (p<0,001). Conclusão: diante dos dados, conclui-se que a adição da carga de SN influencia nas proprie-dades mecânicas de resina acrílica significativamente, destacando-se que a radiopacidade desse material faci-lita a sua remoção quando ingerida ou aspirada.