RESUMO

Type II arabinogalactan (AG) is a polysaccharide found in Maytenus ilicifolia (Celastraceae), a plant reputed as gastroprotective. Oral and intraperitoneal administration of the AG protected rats from gastric ulcers induced by ethanol. No alteration of mechanisms related to acid gastric secretion and gastrointestinal motility were observed. In vitro, the AG showed a potent scavenging activity against the radical of DPPH (2,2-diphenyl-1-picrylhydrazyl) with an IC50 value of 9.3 microM. However, the mechanism of the gastroprotective action remains to be identified.

Assuntos

Galactanos/farmacologia , Trato Gastrointestinal/efeitos dos fármacos , Maytenus/química , Animais , Feminino , Galactanos/isolamento & purificação , Técnicas In Vitro , Ratos , Ratos Wistar