RESUMO
INTRODUCTION AND AIM: The value of leakage testing during colorectal resections to identify anastomotic leaks or bleeding has not been established. Our aim was to compare the impact of intraoperative colonoscopy (IOC) versus insufflation with a syringe, as leakage testing in lower anterior resection (LAR) for rectal cancer, with respect to the incidence of postoperative leakage (PL). MATERIALS AND METHODS: A retrospective study utilizing a prospective database of 426 patients with rectal cancer that underwent elective LAR, within the time frame of January 2015 and December 2019, was conducted. The anastomotic leak test was chosen by the surgeon. The incidence of postoperative leakage was compared between patients that underwent IOC and those that had the syringe leak test, utilizing the logistic regression analysis. Propensity score matching was included. RESULTS: There were no significant differences in the clinical characteristics or morbidity and mortality rates between the two groups. Four patients were excluded, leaving a patient total of 422. Seventy patients with IOC were compared with 352 that had the syringe leak test. The incidence of postoperative leakage was 5.7% in the IOC group and 12.2% in the control group (pâ¯=â¯0.001). After propensity score matching (nâ¯=â¯221), balancing the characteristics between the groups, the incidence of postoperative leakage was 5.7% in the IOC group and 13.9% in the syringe leak test group (pâ¯=â¯0.001). CONCLUSION: IOC was shown to be a safe method for evaluating the integrity of colorectal anastomosis and was associated with a higher percentage of protective stoma use, appearing to reduce the risk for PL.
Assuntos
Fístula Anastomótica , Neoplasias Retais , Anastomose Cirúrgica/efeitos adversos , Fístula Anastomótica/diagnóstico , Fístula Anastomótica/epidemiologia , Fístula Anastomótica/prevenção & controle , Colonoscopia , Humanos , Neoplasias Retais/complicações , Estudos RetrospectivosRESUMO
INTRODUCCIÓN: El cáncer es una importante causa de mortalidad a nivel mundial, lo que ha motivado la búsqueda de compuestos que ayuden a su remisión, incluyendo compuestos naturales. En este contexto, las sesquiterpén quinonas son evaluadas como posibles sustancias antitumorales por sus propiedades citotóxicas. Una de ellas es Ciclozonarona...
INTRODUCTION: Cancer is a major cause of death in the world, which has motivated the search of compounds that could help to its remission, including natural compound. In this context sesquiterpene quinones are evaluated as possible antitumor substances for its cytotoxic properties, one of them is Ciclozonarone...
Assuntos
Humanos , Masculino , Neoplasias da Próstata/tratamento farmacológico , Sesquiterpenos/farmacologia , Sobrevivência Celular/efeitos dos fármacos , Linhagem Celular Tumoral/efeitos dos fármacos , Permeabilidade da Membrana Celular/efeitos dos fármacos , Fibroblastos/efeitos dos fármacos , Citometria de Fluxo , Microscopia de FluorescênciaRESUMO
The effects of bilateral infusions of GABA into the medial frontal cortex of the rat were studied in a delayed spatial alternation task. It was found that GABA (500 mM, 1 microliter/h during 7 days) impaired the performance of the rats in the previously learned task. Upon interruption of the treatment, the animals rapidly recovered normal performance scores. The results show that GABA infusions produce functional deficits similar to those produced by lesions of the frontal cortex. Moreover, the deficits are reversible upon interruption of the treatment. This technique may therefore be a useful tool for studying frontal lobe functions and the involvement of GABAergic mechanisms in cognitive processes.
Assuntos
Atenção/efeitos dos fármacos , Aprendizagem por Discriminação/efeitos dos fármacos , Lobo Frontal/efeitos dos fármacos , Orientação/efeitos dos fármacos , Ácido gama-Aminobutírico/farmacologia , Animais , Mapeamento Encefálico , Masculino , Ratos , Ratos EndogâmicosRESUMO
The most prominent ERP to occur during intervals of preparation and anticipation is the contingent negative variation (CNV) or expectancy wave. The purpose of the study was to distinguish the characteristics of the CNV in a group of children with reading disabilities or dyslexia, and to compare it with a group of normal readers. Nine right handed boys aged between 9 and 13 years with reading disabilities were studied. The children were matched with a group of nine normal readers. Four derivations were used: F3, Cz, P3, and O1, with reference to linked ears. Data were analyzed using multivariate procedures. Significant differences between groups in the CNV amplitude at the left parietal site were observed. We discuss the participation of this zone and we consider processes like expectancy and attention in the differences observed.
Assuntos
Variação Contingente Negativa , Dislexia/fisiopatologia , Eletrofisiologia , Adolescente , Criança , Potenciais Evocados , Humanos , MasculinoAssuntos
Cognição , Classe Social , Adolescente , Adulto , Feminino , Humanos , Masculino , México , Pessoa de Meia-Idade , Fatores SexuaisRESUMO
The group selected for this evaluation consisted of 109 normal people with an average age of 25, coming from two different sociocultural levels (high and low) of Mexico City. All were completely evaluated by Luria's battery for neuropsychological assessment, adapted by Ardila, Ostrosky, and Canseco, 1981. This group of tests measures nine different areas: Motor Functions, Somatosensory Knowledge, Auditory Knowledge, Visuospatial Knowledge, Cognitive Processes, Language, Reading, Writing and Basic Calculations. For all of these, the higher performance standards were achieved by the subjects from the high sociocultural level. A significant interaction between sociocultural level and sex was observed. The differences between sexes appear only in subjects from the low sociocultural level. Factor analysis of the battery revealed that the most sensitive items to sociocultural level were those related on one hand, to the handling of complex structural and conceptual aspects of language and on the other hand, to the organization of motor sequences and in general motor programming. Research related to the differences found is reviewed and implications for clinical assessment are discussed.