1.
P R Health Sci J
; 13(1): 13-5, 1994 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8016289
RESUMO
A glucosidase inhibition assay has been used to evaluate extracts from higher plants. An enzyme inhibition of fifty percent or more correlated with the observed cytotoxicity of the extracts.
Assuntos
Avaliação Pré-Clínica de Medicamentos/métodos , Extratos Vegetais/farmacologia , beta-Glucosidase/antagonistas & inibidores , Antivirais/farmacologia , Morte Celular/efeitos dos fármacos , HIV/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Extratos Vegetais/toxicidade , Porto Rico
2.
P R Health Sci J
; 13(1): 17-8, 1994 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7517050
RESUMO
Extracts from higher plants were evaluated for inhibitory activity against avian myeloblastosis virus reverse transcriptase. The assay may serve as a useful prescreen for potential anti-HIV bioactives.
Assuntos
Antivirais/farmacologia , Avaliação Pré-Clínica de Medicamentos/métodos , Extratos Vegetais/farmacologia , Inibidores da Transcriptase Reversa , Vírus da Mieloblastose Aviária/enzimologia , HIV/efeitos dos fármacos , Porto Rico
3.
J Nat Prod
; 56(8): 1423-5, 1993 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8229020
RESUMO
From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.