RESUMO
INTRODUCTION: Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled. OBJECTIVE: To evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients. METHODS: Prospective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120mg/day), α-lipoic acid (60mg/day)+vitamin C (600mg/day), papaverine hydrochloride (100mg/day)+vitamin E (400mg/day), and placebo. RESULTS: There was no statistically significant difference between THI by degree (p=0.441) and by score (p=0.848) before and after treatment. CONCLUSION: There was no benefit from the use of antioxidant agents for tinnitus in this sample.
Assuntos
Antioxidantes/uso terapêutico , Ginkgo biloba/química , Perda Auditiva Neurossensorial/complicações , Extratos Vegetais/uso terapêutico , Zumbido/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Ácido Ascórbico/uso terapêutico , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Papaverina/uso terapêutico , Fitoterapia/métodos , Estudos Prospectivos , Índice de Gravidade de Doença , Fatores Socioeconômicos , Ácido Tióctico/uso terapêutico , Zumbido/complicações , Resultado do Tratamento , Vitamina E/uso terapêuticoRESUMO
OBJECTIVES: To define anatomic parameters indicating or limiting the use of anterior and retrofacial accesses to sinus tympani (ST). MATERIAL: Anatomic study (30 temporal bones). MAIN OUTCOME MEASURE: The profundity of the ST, the distance between the sigmoid sinus and facial nerve (SS-F), the distance from posterior semicircular canal to the facial nerve, and the capacity of adequate visualization of the ST. RESULTS: Sinus tympani depth was significantly smaller (Assuntos
Nervo Facial/anatomia & histologia
, Procedimentos Cirúrgicos Otológicos/métodos
, Osso Temporal/cirurgia
, Membrana Timpânica/anatomia & histologia
, Membrana Timpânica/cirurgia
, Humanos
, Canais Semicirculares/anatomia & histologia
, Canais Semicirculares/cirurgia
, Osso Temporal/anatomia & histologia