RESUMO
RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experience. The integration of graphical tools provides clear visual representations of genetic regulation data, facilitating data interpretation and knowledge integration. RegulonDB version 12.0 can be accessed at https://regulondb.ccg.unam.mx.
Assuntos
Bases de Dados Genéticas , Escherichia coli K12 , Regulação Bacteriana da Expressão Gênica , Biologia Computacional/métodos , Escherichia coli K12/genética , Internet , Transcrição GênicaRESUMO
Database URL: RegulonDB, http://regulondb.ccg.unam.mx.