RESUMO
Pigmentary superficial keratitis (PSK) is a chronic corneal disorder with different causes, which may include immune-mediated diseases and reactions to ultraviolet rays. This study aimed to evaluate the use of automated central lamellar superficial keratectomy (ACLSK) in the treatment of chronic pigmentary superficial keratitis (CPSK) in dogs. We enrolled 24 animals with CPSK and loss of visual function even after clinical treatment with preserved post-corneal transparent media, and the potential for recovery of visual function after surgical treatment. The microkeratome was positioned on the eye surface, and the central corneal lamellae were obtained after translation. With ACSLC, 21 animals (87.5%) recovered their visual function. In 3 animals (12.5%), the formation of granuloma and posterior central leukoma in the cornea compromised the transparency of the visual axis. This study concludes that ACLSK is a viable surgical alternative for the restoration of visual function in dogs with severe PSK, thus improving their quality of life. The short execution time of this procedure reduces the costs and anesthetic risks.
A ceratite pigmentar superficial (CPS) é uma doença crônica da córnea, com diferentes causas, que podem incluir doenças imunomediadas e reação aos raios ultravioleta. Este estudo teve como objetivo avaliar a utilização da ceratectomia superficial lamelar central automatizada (CSLCA) no tratamento da ceratite superficial pigmentar crônica (CSPC) em cães. Vinte e quatro animais incluídos apresentaram CSPC e perda da função visual mesmo após o tratamento clínico, porém mantiveram os meios transparentes pós-córnea preservados e o potencial de recuperação da função visual após o tratamento cirúrgico. O microcerátomo foi posicionado na superfície do olho e, após o término de sua translação, foram obtidas as lamelas centrais da córnea. Com a CSLCA, 21 animais (87,5%) recuperaram a função visual. Em três animais (12,5%), a formação de granuloma e leucoma central posterior na córnea comprometeu a transparência do eixo visual. Este estudo conclui que a CSLCA é uma alternativa cirúrgica viável para o restabelecimento da função visual em cães com CPS grave, melhorando, assim, sua qualidade de vida. Seu curto tempo de execução proporciona redução de custos e de riscos anestésicos.
Assuntos
Animais , Cães , Doenças do Cão/cirurgia , Ceratectomia/métodos , Ceratite/cirurgia , Ceratite/veterináriaRESUMO
Insecticides may cause mortality and deleterious effects on predatory stinkbugs. For this reason, the effect of five concentrations of permethrin applied on third instar nymphs of Supputius cincticeps (Stål) (Heteroptera: Pentatomidae) was investigated on ovary activation in this predator. The nymphs received topical application of permethrin in the following concentrations (mg a.i./ml): 10(-7), 10(-6), 10(-5), 10(-4), and 10(-3). Ovary lengths and oocyte numbers were quantified following first egg mass. Ovary length of S. cincticeps varied from 5.7 mm with 10(-4) mg a.i./ml, to 6.4 mm with 10(-7) mg a.i./ml, with similar values for the other permethrin concentrations and for the control. The number of oocytes per female varied from 13.5 with 10(-3) mg a.i./ml, to 29.2 for the control, with significant differences. The number of oocytes per female of nymphs exposed to a permethrin concentration of 10(-5) mg a.i./ml was similar to that of the control. However, the lower number of oocytes per female from nymphs exposed to other concentrations of permethrin suggests that this insecticide may affect the reproductive capacity of this predator. The results obtained are discussed in relation to tolerance of Heteroptera predators to insecticides and possible hormesis occurrence.
Assuntos
Heterópteros/efeitos dos fármacos , Inseticidas/farmacologia , Ovário/efeitos dos fármacos , Permetrina/farmacologia , Animais , Feminino , Ninfa/efeitos dos fármacos , Oócitos , Ovário/crescimento & desenvolvimento , Reprodução/efeitos dos fármacosRESUMO
Inseticidas podem causar mortalidade e efeitos deletérios em percevejos predadores. Por isso investigou-se o efeito de cinco concentrações de permetrina aplicadas em ninfas de terceiro estádio de Supputius cincticeps (Stål) (Heteroptera: Pentatomidae) em sua ativação ovariana. Essas ninfas receberam aplicação tópica de permetrina nas seguintes concentrações (mg i.a./ml): 10ù7, 10ù6, 10ù5, 10ù4, 10ù3. O comprimento dos ovários e o número de ovócitos foram quantificados após a primeira postura. O comprimento do ovário variou de 5,7 mm na concentração de 10ù4 mg i.a./ml a 6,4 mm na concentração de 10ù7 mg i.a./ml, com valores semelhantes para as outras concentrações de permetrina e controle. O número de ovócitos por fêmea variou de 13,5 (10ù3 mg i.a./ml) a 29,2 no controle, com diferenças significativas entre concentrações. O número de ovócitos por fêmea, proveniente de ninfas expostas a concentração de 10ù5 mg i.a./ml, foi semelhante àquele do controle. No entanto, o menor número de ovócitos por fêmea, provenientes de ninfas expostas a outras concentrações de permetrina, sugere que esse inseticida pode afetar a capacidade reprodutiva. Esses resultados são discutidos em relação à tolerância de Heteroptera predador aos inseticidas e a possível ocorrência de hormese.
Assuntos
Animais , Feminino , Heterópteros/efeitos dos fármacos , Inseticidas/farmacologia , Ovário/efeitos dos fármacos , Permetrina/farmacologia , Inseticidas/administração & dosagem , Ninfa/efeitos dos fármacos , Oócitos , Ovário/crescimento & desenvolvimento , Permetrina/administração & dosagem , Reprodução/efeitos dos fármacosRESUMO
The objective of this work was to evaluate which nonlinear model [Davidson (1942, 1944), Stinner et al. (1974), Sharpe & DeMichele (1977), and Lactin et al. (1995)] best describes the relationship between developmental rates of the different instars and stages of Alabama argillacea (Hübner) (Lepidoptera: Noctuidae), and temperature. A. argillacea larvae were fed with cotton leaves (Gossypium hirsutum L., race latifolium Hutch., cultivar CNPA 7H) at constant temperatures of 20, 23, 25, 28, 30, 33, and 35ºC; relative humidity of 60 ± 10 percent; and photoperiod of 14:10 L:D. Low R² values obtained with Davidson (0.0001 to 0.1179) and Stinner et al. (0.0099 to 0.8296) models indicated a poor fit of their data for A. argillacea. However, high R² values of Sharpe & DeMichele (0.9677 to 0.9997) and Lactin et al. (0.9684 to 0.9997) models indicated a better fit for estimating A. argillacea development.
Assuntos
Animais , Feminino , Lepidópteros , Temperatura , Dinâmica não LinearRESUMO
The objective of this work was to evaluate which nonlinear model [Davidson (1942, 1944), Stinner et al. (1974), Sharpe & DeMichele (1977), and Lactin et al. (1995)] best describes the relationship between developmental rates of the different instars and stages of Alabama argillacea (Hübner) (Lepidoptera: Noctuidae), and temperature. A. argillacea larvae were fed with cotton leaves (Gossypium hirsutum L., race latifolium Hutch., cultivar CNPA 7H) at constant temperatures of 20, 23, 25, 28, 30, 33, and 35 masculine C; relative humidity of 60 +/- 10%; and photoperiod of 14:10 L:D. Low R(2) values obtained with Davidson (0.0001 to 0.1179) and Stinner et al. (0.0099 to 0.8296) models indicated a poor fit of their data for A. argillacea. However, high R(2) values of Sharpe & DeMichele (0.9677 to 0.9997) and Lactin et al. (0.9684 to 0.9997) models indicated a better fit for estimating A. argillacea development.
Assuntos
Lepidópteros/crescimento & desenvolvimento , Animais , Feminino , Modelos Biológicos , Dinâmica não Linear , TemperaturaRESUMO
A forty-year-old man underwent an allogeneic BMT from his HLA identical sister. GvHD prophylaxis was done with cyclosporine (CyA), methotrexate and prednisone (PDN). On day +90 extensive GvHD was noted and higher doses of immunosuppressive drugs alternating CyA with PDN were initiated. Patient's follow-up was complicated by intermittent episodes of leukopenia and monthly episodes of sinusitis or pneumonia. One year after BMT, the patient developed hoarseness and nasal voice. No etiologic agent could be identified on a biopsy sample of the vocal chord. Upon tapering the doses of immunosuppressive drugs, the patient had worsening of chronic GvHD and was reintroduced on high doses of cyclosporine alternating with prednisone on day +550. Three months later, GvHD remained out of control and the patient was started on azathioprine. On day +700, hoarseness and nasal voice recurred. Another biopsy of the left vocal chord failed to demonstrate infection. Episodes of sinusitis became more frequent and azathioprine was withheld 3 months after it was started. One month later, the patient had bloody nasal discharge and surgical drainage of maxillary sinuses was performed. Histopathology showed hyphae and cultures grew Scedosporium apiospermum. Itraconazole 800 mg/day was initiated. The patient developed progressive respiratory failure and died 15 days later.