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Introducción: La gestión didáctica con la plataforma Moodle requiere profesores aptos para actuar como gestores de dicho proceso. Objetivo: Evaluar las condiciones para mejorar el funcionamiento de las aulas virtuales de la disciplina Bases Biológicas de la Medicina, en el departamento de Ciencias Básicas Biomédicas de la Facultad de Ciencias Médicas Salvador Allende. Métodos: Se realizó una investigación descriptiva, con enfoque mixto, basada en un estudio de campo durante el curso 2023, en el Departamento de Ciencias Básicas Biomédicas de la Facultad de Ciencias Médicas Salvador Allende. Se utilizaron métodos teóricos: análisis-síntesis, deducción-inducción y enfoque sistémico; empíricos: cuestionario; y matemático-estadísticos. Resultados: Se apreciaron como fortalezas la actitud hacia el uso educativo de las tecnologías de la información y las comunicaciones, y el dominio general de estas. Se mostró limitado el uso de las actividades disponibles en la plataforma Moodle, por lo que las condiciones para mejorar el funcionamiento de las aulas virtuales se valoraron como insuficientes. Conclusiones: Para mejorar el funcionamiento de las aulas virtuales del Departamento de Ciencias Básicas Biomédicas de la Facultad de Ciencias Médicas Salvador Allende se requiere fomentar el uso creativo e innovador de las actividades disponibles en la plataforma Moodle, por lo que se debe incrementar la preparación de los profesores para asumir esta actividad. Se sugiere implementar una actividad metodológica departamental con este propósito(AU)

Introduction: Didactic management using the Moodle platform requires professors apt to act as managers of such process. Objective: To assess the conditions to improve the functioning of the virtual classrooms of the discipline Biological Bases of Medicine, in the Department of Basic Biomedical Sciences at Facultad de Ciencias Médicas Salvador Allende. Methods: A descriptive research, with a mixed approach and based on a field study, was carried out during the academic year 2023 in the Department of Basic Biomedical Sciences at Facultad de Ciencias Médicas Salvador Allende. Theoretical methods were used (analysis-synthesis, deduction-induction and systemic approach), as well as empirical methods (questionnaire) and mathematical-statistical methods. Results: Among the appreciated strengths, there was the attitude towards the educational use of information and communication technologies, together with the general mastery of such technologies. The use of the activities available in the Moodle platform was shown to be limited; therefore, the conditions for improving the functioning of virtual classrooms were assessed as insufficient. Conclusions: To improve the functioning of the virtual classrooms of the Department of Basic Biomedical Sciences at Facultad de Ciencias Médicas Salvador Allende, the creative and innovative use of the activities available on the Moodle platform are required to be encouraged; therefore, the training of professors to assume this activity should be increased. A departmental methodological activity is suggested to be implemented with this purpose(AU)

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INTRODUCTION: Aminoglycosides nephrotoxicity limits their use in clinical practice. Growth hormone-releasing peptide-6 (GHRP6) and epidermal growth factor (EGF) have proven cytoprotective effects in various tissues, including the kidney. This study aimed to determine the cytoprotective effect of EGF and GHRP6 on glomerular, proximal tubular, and interstitial morphology in rats treated with an overdose of kanamycin. MATERIALS AND METHODS: Forty-four male Wistar adults rats were submitted to treatment for 20 days with sodium phosphate saline buffer (control group), kanamycin (kanamycin group), kanamycin and EGF (EGF group), kanamycin and GHRP6 (GHRP6 group), kanamycin, EGF, and GHRP6 (EGF-GHRP6 group). The kidneys were studied both during acute kidney injury (n = 19) and recovery phases (n = 25). The percentages of glomerular damage, tubular damage (reversible and irreversible changes), and interstitial damage were quantified in 10 histological fields per kidney using paraffin-embedded sections. RESULTS: The damage in the glomeruli, proximal tubules, and interstitium was less in the groups treated with the cytoprotective treatments than in kanamycin group during acute kidney injury. During the recovery phase, normal structure of several glomeruli and the interstitium was appreciated in the EGF and GHRP6 groups, although tissue repair was not as complete as it in the EGF-GHRP6 group. In the recovery phase, cytoprotective treatments accelerated the recovery of tubular damage and reversible tubular changes prevailed. CONCLUSIONS: These results confirm the cytoprotective properties of EGF and GHRP6 alone and in combination and suggest the possibility of using these agents to accelerate kidney tissue repair after aminoglycoside-induced renal damage.

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