RESUMO

In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of the COMT gene. We also observed that CYP17 and CYP1A1 polymorphisms can modify the risk to BC depending on the menopause status. We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC. These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups.

Assuntos

Neoplasias da Mama/genética , Estrogênios/genética , Instabilidade Genômica/genética , Adulto , Hidrocarboneto de Aril Hidroxilases/genética , Neoplasias da Mama/epidemiologia , Catecol O-Metiltransferase/genética , Células Cultivadas , Citocromo P-450 CYP1A1/genética , Citocromo P-450 CYP1B1 , Estrogênios/metabolismo , Feminino , Genótipo , Humanos , Pessoa de Meia-Idade , Polimorfismo Genético , Fatores de Risco , Esteroide 17-alfa-Hidroxilase/genética