RESUMO
This study was designed to evaluate the hypothesis that the mesolimbic dopamine pathways are involved in the manifestations of psychotic symptoms. Rats were injected with amphetamine (5.0 mg/kg) and apomorphine (1.0 mg/kg) following bilateral lesions of the nucleus accumbens. The results showed high levels of stereotypy following amphetamine administrations in contrast to the low levels seen after the administration of apomorphine. These results, in conjunction with previous experiments involving the globus pallidus, were evaluated in terms of the accumbens' influence on drug-induced psychosis (AU)
Assuntos
21003 , Masculino , Ratos , Anfetamina/farmacocinética , Apomorfina/farmacocinética , Eletrochoque , Núcleo Accumbens , Núcleos Septais , Comportamento Estereotipado/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ratos EndogâmicosRESUMO
The elderly are especially prone to psychological illness. Cognitive impairment increases with age and as this is a primary symptom of many common disorders, it constitutes a major health problem. The elderly also frequently become depressed and have the highest suicide rate of all age groups. Given the increasing numbers of elderly persons in the population, the primary care physician must assume the reponsibility of evaluating, diagnosing and initiating psychiatric treatment with an emphasis on early and accurate diagnosis, and the detection of underlying causes, many of which are reversible (AU)