RESUMO
In order to establish whether tissues damaged by Chronic Periapical Pathology (CPP) of endodontic origin produced heat shock protein (HSP) capable of attracting reactive lymphocytes, paraffin sections of samples from the oral cavity of 10 patients with CPP were incubated with commercially available anti-HSP monoclonal antibodies. Antibodies were evidenced employing the alkaline phosphatase immunoenzymatic method (DAKO). HSP was found in the lamina propria infiltrated by lymphocytes, in six of the ten samples. These results suggest that HSP may be one of the lymphocyte recruiting factors in the damaged area and opens new possibilities for further research.
Assuntos
Proteínas de Choque Térmico/biossíntese , Periodontite Periapical/imunologia , Periodontite Periapical/metabolismo , Adolescente , Adulto , Quimiotaxia de Leucócito , Doença Crônica , Feminino , Proteínas de Choque Térmico/fisiologia , Humanos , Técnicas Imunoenzimáticas , Ativação Linfocitária , Linfócitos/fisiologia , Masculino , Pessoa de Meia-IdadeRESUMO
The biotransformation of flecainide to serum fluoride after the oral administration of 100 mg to six healthy subjects was studied. Fluoride, flecainide acetate, calcium and alkaline phosphatase serum levels were determined at 0, 3, 4.5 and 6 hours after administration. Higher mean serum concentrations for fluoride and alkaline phosphatase (P less than 0.01, P less than 0.005) and lower mean calcium levels (P less than 0.05) were reached at 4.5 hours. The flecainide acetate serum levels ranged from 108 to 261 ng/ml. The results were analyzed for statistical significance by single factor analysis of variance with repeated measures. The Spearman rank correlation coefficient between flecainide acetate and fluoride serum increases was calculated. Our results would suggest that fluorine-containing flecainide could be biotransformed to yield some ionic fluoride which contribute to the daily fluoride intake.
Assuntos
Flecainida/sangue , Fluoretos/sangue , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
La TA en pacientes pediátricos no ha sido estudiada adecuadamente en Venezuela. El presente trabajo se realizó para determinar las cifras tensionales según edad y sexo en escolares de las poblaciones rurales de El Cortijo y Los Bagres, Dtto. Sanitario No. 3, Ed. Aragua y correlacionario con peso, talla, y antecedentes familiares. La muestra fue de 184 niños (94 varones y 90 hembras), con edades entre 7 y 14 años. Se registró el primer, cuarto y quinto ruido de Korotkoff en posición acostado, sentado y de pie, con esfigmomanómetro de mercurio. No se observó diferencia significativa entre las medias aritméticas de varones y hembras. Se evidenció una correlación significativa (p<0,05) y positiva entre TA y peso en la mayoría de los casos. Las cifras de TA registrada en posición sentado fueron siempre las más bajas en ambos sexos (p<0,05). La prevalencia de lecturas elevadas en la primera medición fue de 13,6% (6,0% en varones y 7,6% en hembras, p>0,05); el 5,6% mantendrán cifras elevadas a las cuatro semanas