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Rev Latinoam Microbiol ; 48(3-4): 256-9, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-18293659

RESUMO

A skin biopsy sample was obtained from a relapsed lepromatous leprosy patient from the central area of Mexico. Genes associated with resistance to anti-leprosy drugs were analyzed by DNA sequence assay. A single nucleotide substitution was found at codon 53 (ACC-->GCC) in the folP gene, which is known to confer dapsone resistance. No mutations in the rpoB and gyrA, which indicate resistance to rifampicin and fluoroquinoles, were detected. This is the first reported case of dapsone resistant leprosy in Mexico in which the cause of the resistance is shown at genomic level. Evaluation of drug resistance by identifying known mutations in these genes by PCR is simple and reliable. Testing for resistance to anti-leprosy drugs should be performed in relapses or intractable cases for a better outcome.


Assuntos
Proteínas de Bactérias/genética , DNA Bacteriano/genética , Dapsona/farmacologia , Di-Hidropteroato Sintase/genética , Farmacorresistência Bacteriana/genética , Hansenostáticos/farmacologia , Hanseníase Virchowiana/microbiologia , Mycobacterium leprae/efeitos dos fármacos , Mutação Puntual , Proteínas de Bactérias/fisiologia , Códon/genética , Análise Mutacional de DNA , Dapsona/uso terapêutico , Di-Hidropteroato Sintase/fisiologia , Humanos , Hansenostáticos/uso terapêutico , Hanseníase Virchowiana/tratamento farmacológico , México , Mycobacterium leprae/genética , Mycobacterium leprae/isolamento & purificação , Recidiva , Análise de Sequência de DNA
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