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Vitiligo is an autoimmune disease characterized by progressive skin depigmentation and the appearance of white patches throughout the body caused by significant apoptosis of epidermal melanocytes. Despite not causing any physical pain, vitiligo can originate several psychosocial disorders, drastically reducing patients' quality of life. Emerging evidence has shown that vitiligo is associated with several genetic polymorphisms related to auto-reactivity from the immune system to melanocytes. Melanocytes from vitiligo patients suffer from excess reactive oxygen species (ROS) produced by defective mitochondria besides a poor endogenous antioxidant system (EAS). This redox imbalance results in dramatic melanocyte oxidative stress (OS), causing significant damage in proteins, lipid membranes, and DNA. The damaged melanocytes secret damage-associated molecular pattern (DAMPs), inducing and increasing inflammatory gene expression response that ultimately leads to melanocytes apoptosis. Vitiligo severity has been also associated with increasing the prevalence and incidence of metabolic syndrome (MetS) or associated disorders such as insulin resistance and hypercholesterolemia. Thus, suggesting that in genetically predisposed individuals, the environmental context that triggers MetS (i.e., sedentary lifestyle) may also be an important trigger for the development and severity of vitiligo disease. This paper will discuss the relationship between the immune system and epidermal melanocytes and their interplay with the redox system. Based on state-of-the-art evidence from the vitiligo research, physical exercise (PE) immunology, and redox system literature, we will also propose chronic PE as a potential therapeutic strategy to treat and prevent vitiligo disease progression. We will present evidence that chronic PE can change the balance of inflammatory to an anti-inflammatory state, improve both EAS and the mitochondrial structure and function (resulting in the decrease of OS). Finally, we will highlight clinically relevant markers that can be analyzed in a new research avenue to test the potential applicability of chronic PE in vitiligo disease.

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OBJECTIVES: To describe the degree of disability, anthropometric variables, quality of life (QoL), and school backpack weight in boys and girls aged 11-17 years. The differences in QoL between those who did or did not report low back pain (LBP) were also analyzed. METHODS: Eighty-six girls (13.9 ± 1.9 years of age) and 63 boys (13.7 ± 1.7 years of age) participated. LBP was assessed by questionnaire, and disability using the Roland-Morris Disability Questionnaire. QoL was assessed by the Pediatric Quality of Life Inventory (PedsQL). Multivariate analyses of variance and covariance were used to assess differences between groups. RESULTS: Girls reported higher disability than boys (p = 0.01), and lower QoL in the domains of physical (p < 0.001) and emotional functioning (p < 0.01), psychosocial health (p = 0.02) and physical health summary score (p < 0.001), and on the total PedsQL score (p < 0.01). School backpack weight was similar in both genders (p = 0.61) and in participants with and without LBP (p = 0.15). After adjustments, participants with LBP reported lower physical functioning (p < 0.01), influencing lower physical health summary score (p < 0.01). CONCLUSIONS: Girls had higher disability and lower QoL than boys in the domains of physical and emotional functioning, psychosocial health, and physical health summary scores, and on the total PedsQL score; however, similar school backpack weight was reported. Participants with LBP revealed lower physical functioning and physical health summary score, yet had similar school backpack weight to those without LBP. .

OBJETIVOS: Descrever o grau de incapacidade, as variáveis antropométricas, a qualidade de vida (QV) e o peso das mochilas escolares em meninos e meninas com 11-17 anos. Também são analisadas as diferenças na QV entre os que relataram ou não lombalgia (LBP). MÉTODOS: 86 meninas (13,9 ± 1,9 anos) e 63 meninos (13,7 ± 1,7 anos) participaram. A LBP foi avaliada por um questionário e a incapacidade pelo Questionário Roland-Morris. A QV foi avaliada pelo Questionário Pediátrico sobre Qualidade de Vida (PedsQL). As análises de variância e de covariância multivariadas foram usadas para avaliar as diferenças entre os grupos. RESULTADOS: As meninas relataram maior incapacidade do que os meninos (p = 0,01) e menor QV nos domínios de funcionamento físico (p < 0,001) e emocional (p < 0,01), no escore sumário de saúde psicossocial (p = 0,02) e saúde física (p < 0,001) e no escore total no PedsQL (p < 0,01). O peso das mochilas escolares era semelhante para ambos os sexos (p = 0,61) e para os participantes com e sem LBP (p = 0,15). Após ajustes, os participantes com LBP relataram menor funcionamento físico (p < 0,01), o que influenciou um menor escore sumário de saúde física (p < 0,01). CONCLUSÕES: As meninas tiveram maior incapacidade e menor QV do que os meninos nos domínios de funcionamento físico e emocional, nos escores sumários de saúde psicossocial e física e no escore total no PedsQL; contudo, foi relatado um peso semelhante das mochilas escolares. Os participantes com LBP revelaram menor funcionamento físico e escore sumário de saúde física, mesmo carregando mochilas escolares de mesmo peso do que aqueles sem LBP. .

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OBJECTIVES: To describe the degree of disability, anthropometric variables, quality of life (QoL), and school backpack weight in boys and girls aged 11-17 years. The differences in QoL between those who did or did not report low back pain (LBP) were also analyzed. METHODS: Eighty-six girls (13.9 ± 1.9 years of age) and 63 boys (13.7 ± 1.7 years of age) participated. LBP was assessed by questionnaire, and disability using the Roland-Morris Disability Questionnaire. QoL was assessed by the Pediatric Quality of Life Inventory (PedsQL). Multivariate analyses of variance and covariance were used to assess differences between groups. RESULTS: Girls reported higher disability than boys (p = 0.01), and lower QoL in the domains of physical (p < 0.001) and emotional functioning (p < 0.01), psychosocial health (p = 0.02) and physical health summary score (p < 0.001), and on the total PedsQL score (p < 0.01). School backpack weight was similar in both genders (p = 0.61) and in participants with and without LBP (p = 0.15). After adjustments, participants with LBP reported lower physical functioning (p < 0.01), influencing lower physical health summary score (p < 0.01). CONCLUSIONS: Girls had higher disability and lower QoL than boys in the domains of physical and emotional functioning, psychosocial health, and physical health summary scores, and on the total PedsQL score; however, similar school backpack weight was reported. Participants with LBP revealed lower physical functioning and physical health summary score, yet had similar school backpack weight to those without LBP.

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BACKGROUND: Associations of metabolic syndrome (MetS) with lifestyle behaviors in youth is potentially important for identifying subgroups at risk and encourage interventions. This study evaluates the associations among the clustering of metabolic risk factors and moderate-to-vigorous physical activity (MVPA) in youth. METHODS: The sample comprised 522 girls and 402 boys (N = 924) aged 11 to 17 years. Height, weight, waist circumference (WC), fasting glucose, high-density lipoprotein cholesterol, triglycerides, and blood pressures were measured. Cardiorespiratory fitness (CRF) was assessed using the 20-m shuttle run test. MVPA was estimated with a 3-day diary. Outcome variables were statistically normalized and expressed as z scores. A clustered metabolic risk score was computed as the mean of z scores. Multiple linear regression was used to test associations between metabolic risk and MVPA by sex, adjusted for age, WC, and CRF. RESULTS: After adjustment for potential confounders, MVPA was inversely associated with the clustering of metabolic risk factors in girls, but not in boys; in addition, after adjusting for WC, the statistical model of that relationship was substantially improved in girls. CONCLUSION: MVPA was independently associated with increased risk of MetS in girls. Additional efforts are needed to encourage research with different analytical approach and standardization of criteria for MetS in youth.

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BACKGROUND: Although the prevalence of metabolic syndrome (MetS) has increased in youth, the potential independent contribution of cardiorespiratory fitness (CRF) to the clustering of metabolic risk factors has received relatively little attention. AIM: This study evaluated associations between the clustering of metabolic risk factors and CRF in a sample of youth. SUBJECTS AND METHODS: Height, weight, BMI, fasting glucose, insulin, HDL-cholesterol, triglycerides and blood pressures were measured in a cross-sectional sample of 924 youth (402 males, 522 females) of 11-17 years. CRF was assessed using the 20-metre shuttle run test. Physical activity (PA) was measured with a 3-day diary. Outcome variables were statistically normalized and expressed as Z-scores. A MetS risk score was computed as the mean of the Z-scores. Multiple linear regression was used to test associations between CRF and metabolic risk, adjusted for age, sex, BMI, PA and parental education. RESULTS: CRF was inversely associated with MetS after adjustment for potential confounders. After adjusting for BMI, the relationship between CRF and metabolic risk has substantially improved. CONCLUSION: CRF was independently associated with the clustering of metabolic risk factors in youth of 11-17 years of age.

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BACKGROUND: Generally, the evaluation of the blood pressure response to resistance exercise has been limited to the evaluation of discontinuous casual blood pressure monitoring, often measured at the end of the exercise. DESIGN: To continuously evaluate the blood pressure response at different intensities of leg press exercise with the same duration and number of repetitions. METHODS: Seven normotensive healthy men performed an incremental test on the leg press machine at relative intensities of one repetition maximum (1RM). The blood pressure and heart rate were measured simultaneously to the incremental exercise by a photoplethysmographic method. RESULTS: The mean ± SD peak values of the heart rate, diastolic blood pressure (DBP) and systolic blood pressure (SBP) were obtained on 70% of 1RM and were 145 ± 20 bpm, 113.1 ± 15.4 mmHg, and 192.4 ± 20.0 mmHg, respectively. The SBP was characterized by a decrease followed by an increase during the sets of exercise. The decrease in the SBP was 12-22 mmHg and took approximately 25 seconds to reach the minimum value before the increase. It was observed for all participants in most of the intensities. The rate of increase in the SBP was not statistically different between the intensities. CONCLUSIONS: Both duration and intensity of exercise have an impact on the blood pressure response. Above 30% of 1RM, the SBP decreases in approximately 20 seconds and starts to increase until the end of the set of leg press exercise.

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AIM: The aim of this paper was to compare the quantity and frequency of alcohol use and its associated negative consequences between two groups of college students who were identified as being "risky drinkers." Subjects were randomly allocated in a clinical trial to intervention or control groups. METHODS: Risky drinking use was defined as Alcohol Use Disorders Identification Test (AUDIT) >or=8 and/or Rutgers Alcohol Problem Index (RAPI) >or=5 problems in the previous year. Students who had undergone the Brief Alcohol Screening and Intervention for College Students (BASICS) (N = 145 at baseline; 142 at 12 months, and 103 at 24 months, loss of 29.7%) were compared with a control group (N = 121 at baseline; 121 at 12 months and 113 at 24 months, loss of 9.3%), the nonintervention group. Variables included drinking frequency, quantity and peak consumption, dependence assessment, and family and friends' abuse assessment. RESULTS: Treated students at a 24-month follow-up decreased quantity of alcohol use per occasion and lowered AUDIT and RAPI scores. CONCLUSIONS: This is the first brief intervention work on risky drinking with college students in Brazil and the results are encouraging. However, it is difficult to conduct individual prevention strategies in a country where culture fosters heavy drinking through poor public policy on alcohol and lack of law enforcement.

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Introdução: apesar de se conhecer, atualmente, a dimensão da epidemia da aids, há um relativo desconhecimento sobre a doença entre universitários. Objetivo: levantar o nível de informação sobre as DST/aids, hepatites B e C, assim como analisar a conduta sexual de jovens universitários de um município do interior do estado de São Paulo e obter subsídios para nortear estratégias de prevenção em relação a essa população. Métodos: aplicação de questionário anônimo entre alunos de três Instituições Educacionais de Ensino Superior (IES) da cidade estudada, com metodologia baseada em um plano de amostragem probabilística estratificada e proporcional. Resultados: dos 888 questionários respondidos, 25 foram descartados em função de inconsistências no preenchimento; deste total, 75,3% são do sexo feminino e 77,8% têm até 24 anos de idade; predomina, entre esses alunos, a orientação heterossexual e 81% deles declararam já ter iniciado sua vida sexual; as principais doenças sexualmente transmissíveis são lembradas por mais de 90% da amostra e as hepatites B e C foram mencionadas por 70 a 89% dos pesquisados. Conclusão: encontrou-se um predomínio de mulheres na amostra de universitários pesquisada, sendo que a maioria desses estudantes apresentaram vida sexual ativa, demonstraram conhecimento adequado sobre os métodos contraceptivos, DST/aids, e fizeram referência ao uso do preservativo como a melhor forma de prevenção de DST/aids. Esses alunos iniciaram sua vida sexual com cerca de 17 anos, para os homens, e 18 anos, para as mulheres; e, embora 70% destes jovens tenham relatado uso de preservativo na primeira relação sexual, este número cai para 46,1% na prática atual.

Introduction: nowadays the dimension of the AIDS epidemy is well-known, but the prevention conducts among university students is a subject not widely studied. Objective: collect information about young university students concerning their level of awareness in relation to STD/AIDS, Hepatitis B and C. Methods: an anonymous questionnaire was filled in by students from three universities in the city observed. A methodology based on a plan of stratified-random probabilistic sampling was used. Results: Eight hundred and eighty-eight questionnaires were answered and 25 were excluded due to inconsistent answers; thetotal number, 75,3% are females and are 24 years old; there is a predominance among these students of heterosexuals, and 81% of them stated that they had already started their sexual life; the most important STDs were mentioned by more than 90% of the sampling, and hepatitis B and C were mentioned by 70 to 89% of the students. Conclusion: a predominance of women in the sampling of university students researched was found, most of these students have an active sexual life; they have adequate knowledge on contraceptive methods, STD/AIDS, and they also stated that condom is the best prevention method for STD/ AIDS; these students started their sexual life around 17 years old, in case of men, and 18 years old in case of women; although 70% of these young students said that they had used condom in their first sexual experience, these figures decreased to 46,1% when it was asked about their present conduct.

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