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BACKGROUND: The effects of SARS-CoV-2 gestational exposure on child development remain inconclusive. AIMS: To analyze the effects of SARS-CoV-2 gestational exposure on neurodevelopment until 12 months. STUDY DESIGN: Prospective cohort study conducted in five municipalities in Southeast Brazil from August 2021 to September 2022. SUBJECTS: Infants were recruited from a serological survey performed during neonatal screening and followed up to 12 months old. We included 224 infants exposed to SARS-CoV-2 during pregnancy and 225 non-exposed, according to the serology results of the newborn as well as their mothers and the maternal antenatal RT-PCR results. OUTCOME MEASURES: Developmental assessments were performed at 6 and 12 months using the Survey of Wellbeing of Young Children-Brazilian Version (SWYC-BR). Children with suspected developmental delay (SDD) at 6 and 12 months were considered at high risk for developmental delay (HRDD). Additionally, risk factors associated with SDD were examined. RESULTS: There were 111 children identified with SDD and 52 with HRDD. SARS-CoV-2 gestational exposure was not associated with SDD. Exposure in the first gestational trimester increased SDD risk by 2.15 times compared to the third. Cesarean delivery predicted SDD (OR 1.56; 95%CI 1.01-2.42) and HRDD (OR 1.91; 95%CI 1.04-3.48). Additionally, suspected maternal depression predicted SDD (OR 1.76; 95%CI 1.01-3.10). CONCLUSION: SARS-CoV-2 gestational exposure did not increase the developmental delay risk. However, our findings suggest that the earlier the gestational exposure, the greater the developmental delay risk at 12 months. Cesarean delivery and suspected maternal depression increased the developmental delay risk, independent of virus exposure.
Assuntos
COVID-19 , Complicações Infecciosas na Gravidez , Lactente , Recém-Nascido , Criança , Humanos , Gravidez , Feminino , Pré-Escolar , SARS-CoV-2 , Brasil/epidemiologia , Estudos Prospectivos , COVID-19/epidemiologia , Fatores de Risco , Complicações Infecciosas na Gravidez/epidemiologiaRESUMO
This study aimed to investigate differences in determinants of active aging between older Brazilian and English adults and to verify the association of behavioral, personal, and social determinants with physical health. This cross-sectional study was based on the ELSI-Brazil (2015-2016) and ELSA (2016-2017) cohorts. Active aging determinants included behavior (smoking, sedentary lifestyle, and poor sleep quality), personal (cognitive function and life satisfaction), and social determinants (education, loneliness, and volunteering), according to the World Health Organization. Physical health included activities limitation and multimorbidity. We estimated age- and sex-adjusted prevalence for each indicator and mean score, and used the negative binomial regression for statistical analysis. We included 16,642 participants, 9,409 from Brazil and 7,233 from England. Overall, all active aging determinants were worse in Brazil than in England, except for life satisfaction (no difference). The most remarkable difference was found for social determinants score in Brazil (mean difference of 0.18; p < 0.05), mainly due to a significantly lower education level in Brazil (70.6%; 95% confidence interval - 95%CI: 69.7-71.5) than England (37.1%; 95%CI: 35.1-39.1). All determinants (behavioral, personal, and social) were associated with health in Brazil and in England. However, the behavioral domain was stronger associated with health in England (coefficient = 2.76; 95%CI: 2.46-3.10) than in Brazil (coefficient = 1.38; 95%CI: 1.26-1.50; p < 0.001). Older English adults beneficiate more from healthier behaviors than Brazilians, which depend more on social policies.
Assuntos
Envelhecimento , Humanos , Adulto , Brasil , Estudos Longitudinais , Estudos Transversais , Envelhecimento/psicologia , EscolaridadeRESUMO
OBJECTIVE: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. METHODS: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. RESULTS: In the theory test there was an increase in scores in both methodologies (p < 0.001); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). CONCLUSION: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.
Assuntos
Síndrome do Desconforto Respiratório , Doenças Respiratórias , Humanos , Criança , Estudos Prospectivos , Emoções , AutoimagemRESUMO
Abstract: This study aimed to investigate differences in determinants of active aging between older Brazilian and English adults and to verify the association of behavioral, personal, and social determinants with physical health. This cross-sectional study was based on the ELSI-Brazil (2015-2016) and ELSA (2016-2017) cohorts. Active aging determinants included behavior (smoking, sedentary lifestyle, and poor sleep quality), personal (cognitive function and life satisfaction), and social determinants (education, loneliness, and volunteering), according to the World Health Organization. Physical health included activities limitation and multimorbidity. We estimated age- and sex-adjusted prevalence for each indicator and mean score, and used the negative binomial regression for statistical analysis. We included 16,642 participants, 9,409 from Brazil and 7,233 from England. Overall, all active aging determinants were worse in Brazil than in England, except for life satisfaction (no difference). The most remarkable difference was found for social determinants score in Brazil (mean difference of 0.18; p < 0.05), mainly due to a significantly lower education level in Brazil (70.6%; 95% confidence interval - 95%CI: 69.7-71.5) than England (37.1%; 95%CI: 35.1-39.1). All determinants (behavioral, personal, and social) were associated with health in Brazil and in England. However, the behavioral domain was stronger associated with health in England (coefficient = 2.76; 95%CI: 2.46-3.10) than in Brazil (coefficient = 1.38; 95%CI: 1.26-1.50; p < 0.001). Older English adults beneficiate more from healthier behaviors than Brazilians, which depend more on social policies.
Resumo: Este estudo transversal objetivou investigar as diferenças nos determinantes do envelhecimento ativo entre idosos brasileiros e ingleses, e verificar a associação de determinantes comportamentais, pessoais e sociais com a saúde física. A pesquisa baseou-se nas coortes ELSI-Brasil (2015-2016) e ELSA (2016-2017). Os determinantes do envelhecimento ativo incluíram os determinantes comportamentais (tabagismo, sedentarismo e má qualidade do sono), pessoais (função cognitiva e satisfação com a vida) e sociais (educação, solidão e voluntariado), de acordo com a Organização Mundial da Saúde. A saúde física incluiu limitação de atividades e multimorbidade. Prevalências ajustadas por idade e sexo foram calculadas para cada indicador e escores médios, utilizando-se a regressão binomial negativa para a análise estatística. A pesquisa incluiu 16.642 participantes, sendo 9.409 do Brasil e 7.233 da Inglaterra. No geral, todos os determinantes do envelhecimento ativo foram piores no Brasil do que na Inglaterra, exceto a satisfação com a vida (sem diferença). A diferença mais marcante refere-se ao escore de determinantes sociais no Brasil (diferença média de 0,18; p < 0,05), principalmente devido à escolaridade significativamente menor no Brasil (70,6%; intervalo de 95% de confiança - IC95%: 69,7-71,5) do que na Inglaterra (37,1%; IC95%: 35,1-39,1). Todos os determinantes (comportamentais, pessoais e sociais) estiveram associados à saúde no Brasil e na Inglaterra. No entanto, o domínio comportamental foi mais fortemente associado à saúde na Inglaterra (coeficiente = 2,76; IC95%: 2,46-3,10) do que no Brasil (coeficiente = 1,38; IC95%: 1,26-1,50) (p < 0,001). Idosos ingleses se beneficiam mais de comportamentos mais saudáveis do que os brasileiros, que dependem mais de políticas sociais.
Resumen: Este estudio transversal tuvo como objetivo investigar las diferencias en los determinantes del envejecimiento activo entre personas mayores brasileñas e inglesas, y verificar la asociación de determinantes conductuales, personales y sociales con la salud física. La investigación se basó en las cohortes ELSI-Brasil (2015-2016) y ELSA (2016-2017). Los determinantes del envejecimiento activo incluyeron determinantes conductuales (tabaquismo, sedentarismo y mala calidad del sueño), personales (función cognitiva y satisfacción con la vida) y sociales (educación, soledad y voluntariado), según la Organización Mundial de la Salud. La salud física incluyó la limitación de actividades y la multimorbilidad. Se calcularon las prevalencias ajustadas por edad y sexo para cada indicador y los puntajes medios, usando la regresión binomial negativa para el análisis estadístico. La encuesta incluyó a 16.642 participantes, 9.409 de Brasil y 7.233 de Inglaterra. En general, todos los determinantes del envejecimiento activo fueron peores en Brasil que en Inglaterra, salvo la satisfacción con la vida (sin diferencia). La diferencia más llamativa se refiere al puntaje de los determinantes sociales en Brasil (diferencia media de 0,18; p < 0,05), sobre todo debido al nivel educativo significativamente más bajo en Brasil (70,6%; intervalo de 95% de confianza - IC95%: 69,7-71,5) que en Inglaterra (37,1%; IC95%: 35,1-39,1). Todos los determinantes (conductuales, personales y sociales) se asociaron con la salud en Brasil y en Inglaterra. Sin embargo, el dominio conductual se asoció más fuertemente con la salud en Inglaterra (coeficiente = 2,76; IC 95% 2,46-3,10) que en Brasil (coeficiente = 1,38; IC95%: 1,26-1,50) (p < 0,001). Las personas mayores inglesas se benefician más de comportamientos más saludables que los brasileños, que dependen más de las políticas sociales.
RESUMO
Abstract Objective: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. Methods: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. Results: In the theory test there was an increase in scores in both methodologies (p < 0.001 ); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). Conclusion: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.
RESUMO
Introdução: O Cymbopogon citratus (capim-limão) é uma espécie herbácea pertencente à família Poaceae, que engloba aproximadamente 500 gêneros e 8.000 espécies. Objetivos: Analisar as evidências científicas disponíveis sobre as aplicações terapêuticas de Cymbopogon citratus (capim-limão) na Odontologia durante os últimos dez anos. Métodos: Trata-se de uma revisão integrativa da literatura, que envolveu as seguintes etapas: elaboração da pergunta norteadora, estabelecimento das palavras-chave e dos critérios de inclusão e exclusão de artigos, seleção e análise crítica dos artigos, resultados, discussão e conclusão. Resultados: 8% dos artigos encontrados e analisados nessa revisão de literatura integrativa demonstraram que o Cymbopogon citratus (capim-limão) apresenta potencial terapêutico no que se refere a suas propriedades antimicrobianas, sendo considerado benéfico e promissor na inibição de patógenos colonizadores bacterianos e fúngicos dentários, além de demonstrar baixa citotoxicidade. Conclusão: Apesar da existência de diversas pesquisas in vitro que demonstram eficácia e segurança do uso de diversos compostos de origem natural, nota-se que há poucos protocolos específicos que orientem o profissional cirurgião-dentista para o uso de terapias à base de plantas medicinais e/ou fitoterápicos, como no caso do Cymbopogon citratus (capim-limão). Portanto, são necessários mais estudos para explicar e fundamentar melhor os efeitos do capim-limão na odontologia.
Introduction: Cymbopogon citratus (lemon grass) is an herbaceous species belonging to the Poaceae family, which includes approximately 500 genera and 8,000 species. Objectives: To analyze the available scientific evidence about therapeutic applications of Cymbopogon citratus (lemon grass) in Dentistry over the past ten years. Methods: This is an integrative literature review, which involved the following steps: elaboration of the guiding question, establishment of keywords and criteria for inclusion and exclusion of articles, selection and critical analysis of articles, results, discussion, and conclusion. Results: 8% of the articles found and analyzed in this integrative literature review demonstrated that Cymbopogon citratus (lemon grass) has therapeutic potential because its antimicrobial properties, being considered beneficial and promising in the inhibition of bacterial and fungal dental colonizing pathogens, in addition presents low cytotoxicity. Conclusion: Despite the existence of several in vitro studies that demonstrate the efficacy and safety of natural compounds utilization, there are few specific protocols guiding the dental professional about using based therapies of medicinal and/or phytotherapeutic plants, as in the case of Cymbopogon citratus (lemon grass). Therefore, more studies are necessary to explain and provide a better validation of lemon grass effects in the dentistry practice.
Assuntos
Plantas Medicinais , Saúde Bucal , Cymbopogon , Odontologia , Usos TerapêuticosRESUMO
OBJECTIVE: To verify factors associated with deteriorating lifestyle during the COVID-19 pandemic, including physical activity, cigarette and alcohol intake in lesbians, gays, bisexuals, transsexuals, transvestites and people with related identities (LGBT+). METHODS: This was a cross-sectional study with individuals aged ≥18 years. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). RESULTS: Of the 975 participants, 48.9% (95%CI 45.7;52.1) decreased physical activity, 6.2% (95%CI 4.8;7.9) increased cigarette smoking, and 17.3% (95%CI 15.0;19.8) increased alcohol intake. Physical activity deteriorated among individuals who adhered to mask use (OR=2.26; 95%CI 1.20;4.23), cigarette smoking increased among individuals who had a chronic health condition (OR=2.39; 95%CI 1.03;5.56), and alcohol intake increased among cisgender women (OR=1.95; 95%CI 1.31;2.92) and individuals living with a partner (OR=1.89; 95%CI 1.23;2.91). CONCLUSION: Lifestyle deterioration stood out among cisgender women, individuals with a chronic health condition and those who adhered to mask use.
Assuntos
COVID-19 , Minorias Sexuais e de Gênero , Adolescente , Adulto , Brasil/epidemiologia , Estudos Transversais , Feminino , Humanos , Estilo de Vida , Masculino , Pandemias , SARS-CoV-2RESUMO
OBJETIVO: Verificar fatores associados à piora do estilo de vida, incluindo atividade física e consumo de cigarros e álcool, durante a pandemia de COVID-19, entre lésbicas, gays, bissexuais, transexuais, travestis e identidades relacionadas, Brasil, 2020. MÉTODOS: Estudo transversal, com indivíduos ≥18 anos de idade. Odds ratio (OR) e intervalos de confiança de 95% (IC95%) foram estimados pela regressão logística. RESULTADOS: Dos 975 participantes, 48,9% (IC95% 45,7;52,1) diminuíram sua atividade física; 6,2% (IC95% 4,8;7,9) e 17,3% (IC95% 15,0;19,8) aumentaram o consumo de cigarros e de álcool, respectivamente. Houve piora na realização de atividade física nos que aderiram às máscaras (OR=2,26; IC95% 1,20;4,23), piora no consumo de cigarros naqueles com alguma condição crônica (OR=2,39; IC95% 1,03;5,56) e de álcool nas mulheres cis (OR=1,95; IC95% 1,31;2,92) e indivíduos morando com companheiro(a) (OR=1,89; IC95% 1,23;2,91) CONCLUSÃO: Destacou-se piora do estilo de vida em mulheres cis, indivíduos com uma condição crônica e aqueles que aderiram às máscaras.
OBJETIVO: Verificar factores asociados al empeoramiento del estilo de vida durante la pandemia, incluida actividad física, consumo de cigarrillos y alcohol, en lesbianas, gays, bisexuales, transexuales, travestis e identidades relacionadas (LGBT+). MÉTODOS: Estudio transversal realizado en Brasil en agosto-noviembre, 2020, con individuos ≥18 años. Se utilizó regresión logística para estimar odds ratio (OR) y intervalos de confianza del IC95%. RESULTADOS: De 975 participantes, 48,9% (IC95% 45,7;52,1) disminuyó la práctica de actividad física, 6,2% (IC95% 4,8;7,9) aumentó el consumo de cigarrillos y 17,3% (IC95% 15,0;19,8) aumentó el consumo de alcohol. Hubo empeoramiento en la actividad física entre individuos que adhirieron a mascarillas (OR=2,26; IC95% 1,20;4,23), empeoramiento en consumo de cigarrillos entre individuos con una condición crónica (OR=2,39; IC95% 1,03;5,56), y de alcohol entre mujeres-cis (OR=1,95; IC95% 1,31;2,92) y personas que vivían en pareja (OR=1,89; IC95% 1,23;2,91). CONCLUSIÓN: Se destacó empeoramiento en mujeres cis, individuos con una condición crónica y que adhirieron a las mascarillas.
OBJECTIVE: To verify factors associated with deteriorating lifestyle during the COVID-19 pandemic, including physical activity, cigarette and alcohol intake in lesbians, gays, bisexuals, transsexuals, transvestites and people with related identities (LGBT+). METHODS: This was a cross-sectional study with individuals aged ≥18 years. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). RESULTS: Of the 975 participants, 48.9% (95%CI 45.7;52.1) decreased physical activity, 6.2% (95%CI 4.8;7.9) increased cigarette smoking, and 17.3% (95%CI 15.0;19.8) increased alcohol intake. Physical activity deteriorated among individuals who adhered to mask use (OR=2.26; 95%CI 1.20;4.23), cigarette smoking increased among individuals who had a chronic health condition (OR=2.39; 95%CI 1.03;5.56), and alcohol intake increased among cisgender women (OR=1.95; 95%CI 1.31;2.92) and individuals living with a partner (OR=1.89; 95%CI 1.23;2.91). CONCLUSION: Lifestyle deterioration stood out among cisgender women, individuals with a chronic health condition and those who adhered to mask use.
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Indicadores de Qualidade de Vida , Comportamento Sedentário , Minorias Sexuais e de Gênero/estatística & dados numéricos , Tabagismo/epidemiologia , Consumo de Bebidas Alcoólicas/epidemiologia , Estudos Transversais , COVID-19/epidemiologiaRESUMO
A estimulação elétrica transcraniana (EET) é uma técnica de neuromodulação não invasiva, que tem sido utilizada como coadjuvante no tratamento de transtornos depressivos devido à sua capacidade de modificar a excitabilidade cortical. Objetivo: Analisar os efeitos da EET nos transtornos depressivos e propor parâmetros para a prática clínica. Métodos: Estudo de revisão sistemática no qual foram incluídos ensaios clínicos randomizados que utilizaram a EET no tratamento dos transtornos depressivos, publicados entre 2010 e junho de 2018, nas línguas inglesa e portuguesa. Resultados: Foram encontrados 14.775 estudos, sendo selecionados para a amostra apenas 15 trabalhos. Todos os estudos selecionados utilizaram a EET por corrente contínua e apresentaram semelhanças em relação aos demais parâmetros elétricos de tratamento e locais de aplicação dos eletrodos. Em 12 dos 15 estudos avaliados foi observada melhora significativa (p < 0,05) dos sintomas depressivos e, em relação aos efeitos adversos, constatou-se que são inferiores aos tratamentos convencionais. Conclusão: A EET apresenta eficácia no tratamento dos transtornos depressivos e que isto está diretamente relacionado ao uso adequado dos parâmetros e técnicas de aplicação da corrente elétrica. (AU)
Assuntos
Depressão , Transtorno Depressivo , Estimulação Transcraniana por Corrente Contínua , Neurotransmissores , Estimulação ElétricaRESUMO
BACKGROUND: Ocular allergy is a common disease, especially in the pediatric population, with unpleasant and long-term consequences, including corneal complications and decreased visual acuity. This study reports two cases of corneal shield ulcer due to vernal keratoconjunctivitis, with good results of surgical debridement performed after failure of long-term clinical treatment. Furthermore, this study highlights that this therapeutic approach, although less common, is efficient in treating refractory cases that cause suffering in pediatric patients. CASE PRESENTATION: The first patient was a 7-year-old Caucasian boy with chronic ocular allergy, especially photophobia, who had been treated with eye drops, antihistamine, and corticosteroids for 60 days without success. Biomicroscopy of the right eye showed the presence of gelatinous limbus, giant papillae in the tarsal conjunctiva, and a shield ulcer measuring 6.0 mm vertically and 2.7 mm horizontally. Surgical debridement was performed, and the ulcer did not recur. The second patient was a 4-year-old Caucasian boy with chronic ocular allergy, especially itching and photophobia, who had been treated with eye drops for 1 year without success. Biomicroscopy of the left eye showed a shield ulcer, with a dense central corneal plaque, measuring 8 mm vertically and 3.5 mm horizontally. Surgical debridement of the ulcer was performed immediately because of the chronicity of the case and severity of the lesion, and the treatment was effective. CONCLUSIONS: The treatment of shield ulcers caused by vernal keratoconjunctivitis in the two reported cases was curative and definitive by surgical debridement in the 7-month follow-up period. Therefore, the early debridement of shield ulcers refractory to drug treatment can considerably reduce the time of disease evolution and the probability of ocular complications caused by clinical treatment or disease chronicity. However, this approach is rarely described in the literature and needs to be included in the ophthalmologist's therapeutic arsenal.
Assuntos
Conjuntivite Alérgica/complicações , Úlcera da Córnea/cirurgia , Desbridamento , Criança , Pré-Escolar , Úlcera da Córnea/etiologia , Humanos , Masculino , Acuidade VisualRESUMO
Halitosis can be described as unpleasant odors emanating from the oral cavity. It is usually associated with decomposition action of bacteria present mainly on the back of the tongue and periodontal pockets, and able to produce volatile sulfur compounds. We conducted a study at the Faculty of Dentistry, Federal University of Juiz de Fora and evaluated the therapeutic effect of two natural extracts, Camellia sinensis (green tea) and resveratrol in the form of oral polymer films, to control halitosis. Fifty volunteers (students of health courses) participated in the research after orientation and signing the informed consent form. The anamnesis was made by researchers. The physical examination was made to verify the inclusion criteria. Each participant received 45 polymeric films to be consumed in 15 days (3 films per day). Measurements of the volatile sulfur compound levels were performed using a halimeter in two stages: 1) before use and 2) 15 days after the first administration. Results showed a statistically significant reduction in volatile sulfur compound levels in 71.79% of the volunteers. We concluded that the compounded orodispersible films containing green tea and resveratrol demonstrated excellent results in reducing halitosis.
Assuntos
Camellia sinensis , Portadores de Fármacos , Halitose/tratamento farmacológico , Extratos Vegetais/administração & dosagem , Polímeros/química , Resveratrol/administração & dosagem , Administração Oral , Adulto , Brasil , Camellia sinensis/química , Formas de Dosagem , Esquema de Medicação , Composição de Medicamentos , Liberação Controlada de Fármacos , Feminino , Halitose/diagnóstico , Humanos , Masculino , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Resveratrol/química , Solubilidade , Fatores de Tempo , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: Resveratrol is a polyphenol that has gained momentum in therapeutics in the last few years. OBJECTIVE: In this study, we hypothesised that resveratrol could act prophylactically and/or treat inflammatory lesions of the oral cavity after being delivered by two different formulations of buccal mucoadhesive tablets (F1 and F2, which differed in terms of viscosity agents used). METHODS: This hypothesis was assessed through permeation studies, to verify diffusion of the drug through the buccal mucosa using a porcine model to predict human in vivo behaviour. RESULTS: F2 (tablet with less viscosity agent) presented better permeation than F1, but the amount of drug that crossed the mucosa was still low compared to the amount retained within it (35.90 µg found in the receptor medium and 15.63 mg quantified within the mucosa). CONCLUSION: This accounted for a local effect rather than a systemic one, which is desirable for local processes, such as oral mucositis, lichen planus, erythema multiforme, nicotinic stomatitis, recurrent aphthous stomatitis, among others. In this sense, resveratrol-loaded mucoadhesive tablets appear to be a prominent alternative to prevent and/or cure inflammatory lesions of the oral cavity.
Assuntos
Inflamação/tratamento farmacológico , Mucosa Bucal/metabolismo , Estilbenos/administração & dosagem , Comprimidos/administração & dosagem , Adesividade , Administração Bucal , Animais , Química Farmacêutica/métodos , Sistemas de Liberação de Medicamentos/métodos , Boca/metabolismo , Permeabilidade , Resveratrol , Estomatite/tratamento farmacológico , Suínos , ViscosidadeRESUMO
O objetivo do presente estudo foi avaliar a eficácia ex vivo de um dentifrício dessensibilizante contendo biovidro (Sensodyne® Repair & Protect, GlaxoSmithKline Brasil Ltd., Rio de Janeiro, Brasil), quanto ao potencial de obliteração dos túbulos dentinários e compará-lo com os dentifrícios convencionais (Colgate® Sensitive Pro-Alívio™, Colgate-Palmolive, São Paulo, SP, Brasil e Sensodyne® Rápido Alívio, GlaxoSmithKline Brasil Ltd., Rio de Janeiro, Brasil). Foram utilizados 12 pré-molares humanos divididos em: G1 (n=4) - escovação com Colgate® Sensitive Pró-Alívio; G2 (n=4) - escovação com Sensodyne® Rápido Alívio; e G3 (n=4) - escovação com Sensodyne® Repair & Protect. As amostras foram submetidas à simulação de escovação de um período de oito semanas, com duas escovações diárias e analisadas em microscopia eletrônica de varredura (MEV), quanto à presença e características dos túbulos dentinários; a espectroscopia de raios-X por dispersão em energia (EDS), a fim de avaliar os elementos químicos presentes nos túbulos dentinários. A análise qualitativa da obliteração dos túbulos dentinários foi avaliada por meio das fotomicrografias. Para verificar a distribuição normal dos dados da EDS, utilizou-se o teste de Shapiro-Wilk (p<0,05). De acordo com a normalidade apresentada, foram executados teste t-Student de amostras pareadas e teste de Wilcoxon. No grupo G1 foi verificada diminuição na luz dos túbulos dentinários, enquanto no G2, além da diminuição dos túbulos, nítida deposição de partículas obliteradoras foi observada. No G3, foi detectada não só a obliteração dos túbulos, mas também a diminuição na quantidade dos mesmos; além da formação de uma camada de hidroxidocarbonato de apatita (HCA) sobre a dentina. A análise conjunta dos dados permitiu concluir que os dentifrícios testados foram capazes de ocluir os túbulos dentinários e que o dentifrício Sensodyne® Repair & Protect apresentou melhor eficácia na obliteração dos túbulos dentinários, seguido respectivamente dos dentifrícios Sensodyne® Rápido Alívio e Colgate® Sensitive Pró-Alívio.
Assuntos
Sensibilidade da Dentina , Dessensibilizantes Dentinários , DentifríciosRESUMO
BACKGROUND: Dentin hypersensitivity is a short, severe pain with fast onset. Therapy aims to either prevent or decrease neural transmission or physically occlude the dentinal tubules. This study aimed to evaluate the effectiveness of commercial desensitizing dentifrice by means of an ex vivo method. MATERIAL AND METHODS: Samples (n=8 lower human premolars for each group) were randomly allocated into: G1- brushing with Colgate®Sensitive Pro-Relief; G2- brushing with Sensodyne®Rapid Relief; G3- brushing with Sensodyne®Repair & Protect; and G4- brushing with Colgate®Maximum Cavity Protection. The test bodies were submitted to simulated toothbrushing and dentifrices were analyzed regarding their hydrodynamic size, polydispersity index (PI) and zeta potential. Specimens were evaluated using: scanning electron microscopy (SEM); spectroscopy energy dispersive X-ray (EDS); and profilometry. A qualitative analysis of the photomicrographs and topographies was performed. RESULTS: The dentifrices showed statistical similar physical and chemical characteristics. They also demonstrated obliteration of dentinal tubules when micrographs were observed. Regarding the chemical elements present in the dentin samples, there was a statistically significant difference between the control and experimental surfaces in the four groups. CONCLUSIONS: Joint data analysis shows that the desensitizing dentifrice showed better results with regards to the obliteration of dentinal tubules compared to positive and negative controls. Key words:Dentin hypersensitivity, dentin desensitizing agents, toothpastes.